Analysis of empiric antimicrobial strategies for cellulitis in the era of methicillin-resistant Staphylococcus aureus

Annals of Pharmacotherapy

Volumn 41, Issue 1, 2007, Pages 13-20

  Phillips, Suzanne ^a   MacDougall, Conan ^b   Holdford, David A ^a  

^a VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Cellulitis; Cost effectiveness; Methicillin resistant Staphylococcus aureus

Indexed keywords

CEFALEXIN; CLINDAMYCIN; COTRIMOXAZOLE; LINEZOLID;

ANTIBIOTIC THERAPY; ARTICLE; CELLULITIS; COST EFFECTIVENESS ANALYSIS; DECISION TREE; DRUG COST; HUMAN; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; OUTPATIENT CARE; PRIORITY JOURNAL; PROBABILITY; SENSITIVITY ANALYSIS; STAPHYLOCOCCUS AUREUS;

ANTI-INFECTIVE AGENTS; CELLULITIS; COST-BENEFIT ANALYSIS; DECISION TREES; EMPIRICAL RESEARCH; HUMANS; METHICILLIN RESISTANCE; PROBABILITY; STAPHYLOCOCCAL INFECTIONS; STAPHYLOCOCCUS AUREUS;

EID: 33846487987     PISSN: 10600280     EISSN: None     Source Type: Journal    
DOI: 10.1345/aph.1H452     Document Type: Article

References (50)

1. Pitts SR, Steinberg JP. Is there an epidemic of skin and soft tissue infections? (abstract 1052). Presented at: the 43rd Annual Meeting of the Infectious Diseases Society of America, San Francisco, October 6-9, 2005.
2. Swartz MN. Clinical practice. Cellulitis. N Engl J Med 2004;350:904-12.
3. Ginsberg MB. Cellulitis: analysis of 101 cases and review of the literature. South Med J 1981;74:530-3.
4. Brook I, Frazier EH. Clinical features and aerobic and anaerobic microbiological characteristics of cellulitis. Arch Surg 1995;130:786-92.
5. Hook EW 3rd, Hooton TM, Horton CA, Coyle MB, Ramsey PG, Turck M. Microbiologic evaluation of cutaneous cellulitis in adults. Arch Intern Med 1986;146:295-7.
6. Sigurdsson AF, Gudmundsson S. The etiology of bacterial cellulitis as determined by fine-needle aspiration. Scand J Infect Dis 1989;21:537-42.
7. Lutomski DM, Trott AT, Runyon JM, Miyagawa CI, Staneck JL, Rivera JO. Microbiology of adult cellulitis. J Fam Pract 1988;26:45-8.
8. Bernard P, Bedane C, Mounier M, Denis F, Catanzano G, Bonnetblanc JM. Streptococcal cause of erysipelas and cellulitis in adults. A microbiologic study using a direct immunofluorescence technique. Arch Dermatol 1989;125:779-82.
9. Stevens DL, Bisno AL, Chambers HF, et al. Practice guidelines for the diagnosis and management of skin and soft-tissue infections. Clin Infect Dis 2005;41:1373-406.
10. Eady EA, Cove JH. Staphylococcal resistance revisited: community-acquired methicillin resistant Staphylococcus aureus-an emerging problem for the management of skin and soft tissue infections. Curr Opin Infect Dis 2003;16:103-24.
11. Tacconelli E, Venkataraman L, De Girolami PC, DAqata EM. Methicillin-resistant Staphylococcus aureus bacteraemia diagnosed at hospital admission: distinguishing between community-acquired versus healthcare-associated strains. J Antimicrob Chemother 2004;53:474-9.
12. Salgado CD, Farr BM, Calfee DP. Community-acquired methicillin-resistant Staphylococcus aureus: a meta-analysis of prevalence and risk factors. Clin Infect Dis 2003;36:131-9.
13. Morin CA, Hadler JL. Population-based incidence and characteristics of community-onset Staphylococcus aureus infections with bacteremia in 4 metropolitan Connecticut areas, 1998. J Infect Dis 2001;184:1029-34.
14. Charlebois ED, Perdreau-Remington F, Kreiswirth B, et al. Origins of community strains of methicillin-resistant Staphylococcus aureus. Clin Infect Dis 2004;39:47-54.
15. Jernigan JA, Pullen AL, Partin C, Jarvis WR. Prevalence of and risk factors for colonization with methicillin-resistant Staphylococcus aureus in an outpatient clinic population. Infect Control Hosp Epidemiol 2003;24:445-50.
16. Naimi TS, LeDell KH, Como-Sabetti K, et al. Comparison of community- and health care-associated methicillin-resistant Staphylococcus aureus infection. JAMA 2003;290:2976-84.
17. Fridkin SK, Hageman JC, Morrison M, et al. Methicillin-resistant Staphylococcus aureus disease in three communities. N Engl J Med 2005;352:1436-44.
18. Chambers HF. Community-associated MRSA-resistance and virulence converge. N Engl J Med 2005;352:1485-7.
19. Sabol KE, Echevarria KL, Lewis JS II. Community-associated methicillin-resistant Staphylococcus aureus: new bug, old drugs. Ann Pharmacother 2006;40:1125-33. Epub 30 May 2006. DOI 10.1345/aph.1G404
20. Rennie RP, Jones RN, Mutnick AH. Occurrence and antimicrobial susceptibility patterns of pathogens isolated from skin and soft tissue infections: report from the SENTRY Antimicrobial Surveillance Program (United States and Canada, 2000). Diagn Microbiol Infect Dis 2003;45:287-93.
21. Draghi DC, Sheehan DF, Hogan P, Sahm DF. Current antimicrobial resistance profiles among methicillin-resistant Staphylococcus aureus encountered in the outpatient setting. Diagn Microbiol Infect Dis 2006;55:129-33.
22. Gordon KA, Beach ML, Biedenbach DJ, Jones RN, Rhomberg PR, Mutnick AH. Antimicrobial susceptibility patterns of beta-hemolytic and viridans group streptococci: report from the SENTRY Antimicrobial Surveillance Program (1997-2000). Diagn Microbiol Infect Dis 2002;43:157-62.
23. Lee PC, Turnidge J, McDonald PJ. Fine-needle aspiration biopsy in diagnosis of soft tissue infections. J Clin Microbiol 1985;22:80-3.
24. Epperly TD. The value of needle aspiration in the management of cellulitis. J Fam Pract 1986;23:337-40.
25. Liles DK, Dall LH. Needle aspiration for diagnosis of cellulitis. Cutis 1985;36:63-4.
26. Ambler AW, Spiers K, Donabedian S, et al. Clinical characteristics, household transmission, and outcome of infection of community-associated methicillin-resistant Staphylococcus aureus (abstract 1049). Presented at: the 43rd Annual Meeting of the Infectious Diseases Society of America, San Francisco, October 6-9, 2005.
27. Iyer S, Jones DH. Community-acquired methicillin-resistant Staphylococcus aureus skin infection: a retrospective analysis of clinical presentation and treatment of a local outbreak. J Am Acad Dermatol 2004;50:854-8.
28. Graham PL III, Lin SX, Larson EL. A U.S. population-based survey of Staphylococcus aureus colonization. Ann Intern Med 2006;144:318-25.
29. King MD, Humphrey BJ, Wang YF, Kourbatova EV, Ray SM, Blumberg HM. Emergence of community-acquired methicillin-resistant Staphylococcus aureus USA 300 clone as the predominant cause of skin and soft-tissue infections. Ann Intern Med 2006;144:309-17.
30. Hidron AI, Kourbatova EV, Halvosa JS, et al. Risk factors for colonization with methicillin-resistant Staphylococcus aureus (MRSA) in patients admitted to an urban hospital: emergence of community-associated MRSA nasal carriage. Clin Infect Dis 2005;41:159-66.
31. Frazee BW, Lynn J, Charlebois ED, Lambert L, Lowery D, Perdreau-Remington F. High prevalence of methicillin-resistant Staphylococcus aureus in emergency department skin and soft tissue infections. Ann Emerg Med 2005;45:311-20.
32. Moran GJ, Krishnadasan A, Gorwitz RJ, et al. Methicillin-resistant S. aureus infections among patients in the emergency department. N Engl J Med 2006;355:666-74.
33. Dillon HC Jr. Treatment of staphylococcal skin infections: a comparison of cephalexin and dicloxacillin. J Am Acad Dermatol 1983;8:177-81.
34. Lipsky BA, Yarbrough DR 3rd, Walker FB 4th, Powers RD, Morman MR. Ofloxacin versus cephalexin for treating skin and soft tissue infections. Int J Dermatol 1992;31:443-5.
35. Tack KJ, Littlejohn TW, Mailloux G, Wolf MM, Keyserling CH. Cefdinir versus cephalexin for the treatment of skin and skin-structure infections. The cefdinir adult skin infection study group. Clin Ther 1998;20:244-56.
36. Parish LC, Routh HB, Miskin B, et al. Moxifloxacin versus cephalexin in the treatment of uncomplicated skin infections. Int J Clin Pract 2000;54:497-503.
37. Jemni L, Hmouda H, Letaief A. Efficacy of trimethoprim-sulfamethoxazole against clinical isolates of methicillin-resistant Staphylococcus aureus: a report from Tunisia. Clin Infect Dis 1994;19:202-3.
38. Stein A, Bataille JF, Drancourt M, et al. Ambulatory treatment of multidrug-resistant Staphylococcus-infected orthopedic implants with high-dose oral co-trimoxazole (trimethoprim-sulfamethoxazole). Antimicrob Agents Chemother 1998;42:3086-91.
39. Markowitz N, Quinn EL, Saravolatz LD. Trimethoprim-sulfamethoxazole compared with vancomycin for the treatment of Staphylococcus aureus infection. Ann Intern Med 1992;117:390-8.
40. Pusponegoro EH, Wiryadi BE. Clindamycin and cloxacillin compared in the treatment of skin and soft-tissue infections. Clin Ther 1990;12:236-41.
41. Reinhardt JF, Johnston L, Ruane P, et al. A randomized, double-blind comparison of sulbactam/ampicillin and clindamycin for the treatment of aerobic and aerobic-anaerobic infections. Rev Infect Dis 1986;8(suppl 5):S569-75.
42. Gooch WM 3rd, Kaminester L, Cole GW, et al. Clinical comparison of cefuroxime axetil, cephalexin and cefadroxil in the treatment of patients with primary infections of the skin or skin structures. Dermatologica 1991;183:36-43.
43. Richter SS, Heilmann KP, Beekmann SE, et al. Macrolide-resistant Streptococcus pyogenes in the United States, 2002-2003. Clin Infect Dis 2005;41:599-608.
44. Rex JH, Pfaller MA. Has antifungal susceptibility testing come of age? Clin Infect Dis 2002;35:982-9.
45. State of Virginia. Federal Upper Limit cost estimates for drugs, www. dmas.virginia.gov/downloads/pdfs/pharm-va_mac_list_june (accessed 2006 Jun 24).
46. Destination Rx. www.rxdestination.com (accessed 2006 Jun 14).
47. American Medical Association. CPT online database. https://catalog. ama-assn.org/Catalog/cpt/cpt_home.jsp (accessed 2006 Jun 24).
48. Le TP, Miller LG. Empirical therapy for uncomplicated urinary tract infections in an era of increasing antimicrobial resistance: a decision and cost analysis. Clin Infect Dis 2001;33:615-21.
49. Vinken AG, Li JZ, Balan DA, Rittenhouse BE, Willke RJ, Goodman C. Comparison of linezolid with oxacillin or vancomycin in the empiric treatment of cellulitis in US hospitals. Am J Ther 2003;10:264-74.
50. Zetola N, Francis JS, Nuermberger EL, Bishai WR. Community-acquired methicillin-resistant Staphylococcus aureus: an emerging threat. Lancet Infect Dis 2005;5:275-86.