Determination of dopamine and its relativity of baicalin in rat nuclei after intravenous administration of flavonoids from Scutellariae radix

Biomedical Chromatography

Volumn 21, Issue 1, 2007, Pages 84-88

  Chen, Long ^a   Zhang, Lujun ^a   Wang, Xueli ^a   Lin, Han ^a   Du, Lijun ^a  

^a TSINGHUA UNIVERSITY   (China)

Author keywords

Baicalin; Cerebral nuclei; Dopamine; Neurotransmitter

Indexed keywords

AMINES; BRAIN; CHEMICAL DETECTION; FLAVONOIDS; NEUROPHYSIOLOGY;

ACTIVE COMPONENTS; BAICALIN; BLOOD-BRAIN BARRIER; CEREBRAL NUCLEUS; DOPAMINE; ELECTROCHEMICAL DETECTION METHOD; FLAVONOID; HPLC-ELECTROCHEMICAL DETECTION; INTRAVENOUS ADMINISTRATION; NEUROTRANSMITTER;

RELATIVITY;

BAICALIN; DOPAMINE; FLAVONOID; SCUTELLARIAE RADIX;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; BRAIN FUNCTION; BRAIN NUCLEUS; CONTROLLED STUDY; DOPAMINERGIC SYSTEM; DRUG BRAIN LEVEL; DRUG DISTRIBUTION; DRUG MECHANISM; DRUG PENETRATION; DRUG TARGETING; ELECTROCHEMICAL DETECTION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MALE; NONHUMAN; RAT;

RATTUS; SCUTELLARIA RADIX;

EID: 33846486228     PISSN: 02693879     EISSN: 10990801     Source Type: Journal    
DOI: 10.1002/bmc.722     Document Type: Article

References (18)

1. Burke WJ, Li SW, Chung HD, Ruffiero DA, Kristal BS, Johnsom EM, Lampe P, Kumar VB, Franko M, Williams EA and Zahm DS. Neurotoxicity of MAO metabolites of catecholamine neurotransmitters: role in neurodegenerative diseases. Neurotoxicology 2004; 25(1-2): 101-115.
2. Cameron OG, Abelson JL and Young EA. Anxious and depressive disorders and their comorbidity: effect on central nervous system noradrenergic function. Biological Psychiatry 2004; 56(11): 875-883.
3. Chan FL, Choi HL, Chen ZY, Chan PSF and Huang Y. Induction of apoptosis in prostate cancer cell lines by a flavonoid, baicalin. Cancer Letters 2000; 160(2): 219-228.
4. Del Bigio MR and Vriend JP. Monoamine neurotransmitters and amino acids in the cerebrum and striatum of immature rats with kaolin-induced hydrocephalus. Brain Research 1998; 798(1-2): 119-126.
5. Gao ZH, Huang KX, Yang XL and Xu HB. Free radical scavenging and antioxidant activities of flavonoids extracted from the radix of Scutellaria baicalensis Georgi. Biochimica et Biophysica Acta 1999; 1472(3): 643-650.
6. Huang ZQ, Yang YJ, Li XZ and Chen X. Plasma and cerebrospinal fluid pharmacokinetics of baicalin in the rabbit model of brain edema. Chinese Journal of Contemporary Pediatrics 1999; 1(3): 146-148.
7. Hui KM, Wang XH and Xue H. Interaction of flavones from the roots of Scutellaria baicalensis with the benzodiazepine site. Planta Medica 2000; 66(1): 91-93.
8. Kondo Y, Kondo F, Asanuma M, Tanaka K and Ogawa N. Protective effect of oren-gedoku-to against induction of neuronal death by transient cerebral ischemia in the C57BL/6 mouse. Neurochemical Research 2000; 25(2): 205-209.
9. Liao JF, Hung WY and Chen CF. Anxiolytic-like effects of baicalein and baicalin in the Vogel conflict test in mice. European Journal of Pharmacology 2003; 464(2-3): 141-146.
10. Li H, Wang H, Chen JH, Wang LH, Zhang HS and Fan Y. Determination of amino acid neurotransmitters in cerebral cortex of rats administered with baicalin prior to cerebral ischemia by capillary electrophoresis-laser-induced fluorescence detection. Journal of Chromatography B 2003; 788(1): 93-101.
11. Liu TP, Liu M, Tsai CC, Lai TY, Hsu FL and Cheng JT. Stimulatory effect of paeoniflorin on the release of noradrenaline from ileal synaptosomes of guinea-pig in-vitro. Journal of Pharmacy and Pharmacology 2002; 54(5): 681-688.
12. Shen YC, Chou WF, Chou YC and Chen CF. Mechanisms in mediating the anti-inflammatory effects of baicalin and baicalein in human leukocytes. European Journal of Pharmacology 2003; 465(1-2): 171-181.
13. Wilhelm K, Boyce P and Brownhill S. The relationship between interpersonal sensitivity, anxiety disorders and major depression. Journal of Affective Disorders 2004; 79(1-3): 33-41.
14. Xu J, Murakami Y, Matsumoto K, Tohda M, Watanabe H, Zhang SH, Yu GH and Shen J. Protective effect of Oren-gedokuto (Huang-Lian-Jie-Du-Tang) against impairment of learning and memory induced by transient cerebral ischemia in mice. Journal of Ethnopharmacology 2000; 73(3): 405-413.
15. Zhang LJ, Xing DM, Ding Y, Wang RF, Wang XL and Du LJ. A chromatographic method for baicalin quantification in rat thalamus. Biomedical Chromatography 2005a; 19(7): 494-497.
16. Zhang LJ, Xing DM, Ding Y, Wang RF and Du LJ. Determination of baicalin in rat hippocampus by RP-LC after intravenous administration of flavonoids from Scutellariae radix. Chromatographia 2005b; 61(9-10): 465-469.
17. Zhang LJ, Xing DM, Wang W, Wang RF and Du LJ. Kinetic difference of baicalin in rat blood and cerebral nuclei after intravenous administration of Scutellariae Radix extract. Journal of Ethnopharmacology 2006; 103(1): 120-125.
18. Zhao HY, Zhang F, Fan SD and Sun LH. Effects of baicalin on contents of PGE_2 and cAMP in hypothalamus of fever rats. Chinese Journal of Applied Physiology 2002; 18(2): 139-141.