Coupling of lactose molecules to the carrier protein hinders the spleen and bone marrow uptake of doxorubicin conjugated with human albumin

European Journal of Pharmaceutical Sciences

Volumn 30, Issue 2, 2007, Pages 136-142

  Di Stefano, Giuseppina ^a   Fiume, Luigi ^a   Baglioni, Michele ^a   Busi, Corrado ^a   Chieco, Pasquale ^b   Kratz, Felix ^c   Mattioli, Alessandro ^a  

^a UNIVERSITY OF BOLOGNA   (Italy)

^b UNIVERSITY OF BOLOGNA   (Italy)

^c UNIVERSITY OF FREIBURG   (Germany)

Author keywords

Albumin conjugate of doxorubicin; Doxorubicin; Hepatocellular carcinoma; Macrophages; Tumour targeting of doxorubicin

Indexed keywords

ASIALOGLYCOPROTEIN RECEPTOR; DOXORUBICIN; HUMAN SERUM ALBUMIN;

AMINATION; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BONE MARROW; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG ACCUMULATION; DRUG CONJUGATION; DRUG PROTEIN BINDING; DRUG UPTAKE; HUMAN; LACTOSAMINATION; LEUKOPENIA; LIVER CELL CARCINOMA; MACROPHAGE MIGRATION INHIBITION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SPLEEN;

ANIMALS; ANTIBIOTICS, ANTINEOPLASTIC; BONE MARROW; CARBON RADIOISOTOPES; CARCINOMA, HEPATOCELLULAR; CELL PROLIFERATION; DIETHYLNITROSAMINE; DOSE-RESPONSE RELATIONSHIP, DRUG; DOXORUBICIN; DRUG CARRIERS; FEMALE; HUMANS; LACTOSE; LIVER NEOPLASMS, EXPERIMENTAL; LYMPHOCYTES; MACROPHAGES; MALE; MICE; RATS; RATS, WISTAR; SERUM ALBUMIN; SPLEEN; TIME FACTORS; TUMOR CELLS, CULTURED;

EID: 33846457561     PISSN: 09280987     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejps.2006.10.012     Document Type: Article

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