The schistosome enzyme that activates oxamniquine has the characteristics of a sulfotransferase

Memorias do Instituto Oswaldo Cruz

Volumn 101, Issue SUPPL. 1, 2006, Pages 307-312

  Pica Mattoccia, Livia ^a   Carlini, Daniele ^a   Guidi, Alessandra ^a   Cimica, Velasco ^a   Vigorosi, Fabio ^a   Cioli, Donato ^a  

^a CNR   (Italy)

Author keywords

Drug activation; Mechanism of action; Oxamniquine; Schistosoma mansoni; Sulfotransferase

Indexed keywords

SCHISTOSOMA; SCHISTOSOMA MANSONI;

EID: 33846452944     PISSN: 00740276     EISSN: 16788060     Source Type: Journal    
DOI: 10.1590/S0074-02762006000900048     Document Type: Conference Paper

References (21)

1. Archer S, El-Hamouly W, Seyed-Mozaffari A, Butler RH, Pica-Mattoccia L, Cioli D 1990. Mode of action of the schistosomicide hycanthone: Site of DNA alkylation. Mol Biochem Parasitol 43: 89-96.
2. Borthwick EB, Burchell A, Coughtrie MW 1993. Purification and immunochemical characterization of a male-specific rat liver oestrogen sulphotransferase. Biochem J 289: 719-725.
3. Cioli D 1976. Transfer of Schistosoma mansoni into the mesenteric veins of hamsters. Int J Parasitol 6: 349-354.
4. Cioli D, Pica-Mattoccia L, Archer S 1995. Antischistosomal drugs: past, present ... and future? Pharmacol Ther 68: 35-85.
5. Cioli D, Pica-Mattoccia L, Moroni R 1992. Schistosoma mansoni: hycanthone / oxamniquine resistance is controlled by a single autosomal recessive gene. Exp Parasitol 75: 425-432.
6. Cioli D, Pica-Mattoccia L, Rosenberg S, Archer S 1985. Evidence for the mode of antischistosomal action of hycanthone. Life Sci 37: 161-167.
7. Coura JR, Amaral RS 2004. Epidemiological and control aspects of schistosomiasis in Brazilian endemic areas. Mem Inst Oswaldo Cruz 99 (Suppl. 1): 13-19.
8. Falany CN, Vazquez ME, Heroux JA, Roth JA 1990. Purification and characterization of human liver phenol-sulfating phenol sulfotransferase. Arch Biochem Biophys 278: 312-318.
9. Glatt H 1997. Bioactivation of mutagens via sulfation. FASEB J 11: 314-321.
10. Kobashi K, Fukaya Y, Kim DH, Akao T, Takebe S 1986. A novel type of aryl sulfotransferase obtained from an anaerobic bacterium of human intestine. Arch Biochem Biophys 245: 537-539.
11. LoVerde PT, Hirai H, Merrick JM, Lee NH, El-Sayed N 2004. Schistosoma mansoni genome project: an update. Parasitol Int 53: 183-192.
12. Oeda T, Lee YC, Driscoll WJ, Chen HC, Strott CA 1992. Molecular cloning and expression of a full-length complementary DNA encoding the guinea pig adrenocortical estrogen sulfotransferase. Mol Endocrinol 6: 1216-1226.
13. Petrotchenko EV, Pedersen LC, Borchers CH, Tomer KB, Negishi M 2001. The dimerization motif of cytosolic sulfotransferases. FEBS Lett 490: 39-43.
14. Pica-Mattoccia L, Archer S, Cioli D 1992. Hycanthone resistance in schistosomes correlates with the lack of an enzymatic activity which produces the covalent binding of hycanthone to parasite macromolecules. Mol Biochem Parasitol 55: 167-176.
15. Pica-Mattoccia L, Cioli D, Archer S 1988. Binding of tritiated hycanthone and hycanthone N-methylcarbamate to macromolecules of drug-sensitive and drug-resistant schistosomes. Mol Biochem Parasitol 31: 87-96.
16. Pica-Mattoccia L, Cioli D, Archer S 1989. Binding of oxamniquine to the DNA of schistosomes. Trans R Soc Trop Med Hyg 83: 373-376.
17. Robbins PW, Lipmann F 1957. Isolation and identification of active sulfate. J Biol Chem 229: 837-851.
18. Robbins PW, Lipmann F 1958. Enzymatic synthesis of adenosine-5′- phosphosulfate. J Biol Chem 233: 686-690.
19. Varin L, Barron D, Ibrahim RK 1987. Enzymatic assay for flavonoid sulfotransferase. Anal Biochem 161: 176-180.
20. Verjovski-Almeida S, DeMarco R, Martins EA et al. 2003. Transcriptome analysis of the acoelomate human parasite Schistosoma mansoni. Nat Genet 35: 148-157.
21. WHO 2002. Prevention and control of schistosomiasis and soil-transmitted helminthiasis. Report of WHO Expert Committee, Geneva.