Is long-term glucocorticoid therapy associated with a high prevalence of asymptomatic vertebral fractures?

Nature Clinical Practice Endocrinology and Metabolism

Volumn 3, Issue 2, 2007, Pages 86-87

  Weinstein, Robert S ^a,b,c,d  

^a Department of Medicine ^*  (United States)

^b Center for Osteoporosis and Metabolic Bone Diseases   (United States)

^c UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

^d UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BISPHOSPHONIC ACID DERIVATIVE; CALCIUM; GLUCOCORTICOID; PREDNISONE; VITAMIN D;

ASTHMA; BONE DENSITY; CHRONIC OBSTRUCTIVE LUNG DISEASE; CLINICAL TRIAL; CONNECTIVE TISSUE DISEASE; CORRELATION ANALYSIS; CORTICOSTEROID INDUCED OSTEOPOROSIS; DAILY LIFE ACTIVITY; DEMOGRAPHY; DUAL ENERGY X RAY ABSORPTIOMETRY; ECHOGRAPHY; HIP; HUMAN; INTERVIEW; LONG TERM CARE; LUMBAR SPINE; NONHUMAN; NOTE; OSTEOBLAST; OSTEOCYTE; OSTEOPOROSIS; OUTPATIENT; POSTMENOPAUSE; PREVALENCE; PRIORITY JOURNAL; QUALITY OF LIFE; QUANTITATIVE ANALYSIS; QUESTIONNAIRE; RHEUMATIC POLYMYALGIA; RHEUMATOID ARTHRITIS; RISK FACTOR; SCORING SYSTEM; SPINE RADIOGRAPHY; STEROID THERAPY; SYSTEMIC LUPUS ERYTHEMATOSUS; TREATMENT DURATION; VERTEBRA FRACTURE; VITAMIN SUPPLEMENTATION;

EID: 33846445255     PISSN: 17458366     EISSN: 17458374     Source Type: Journal    
DOI: 10.1038/ncpendmet0372     Document Type: Note

References (5)

1. LoCascio V et al. (1990) Bone loss in response to long-term glucocorticoid therapy. Bone Miner 8: 39-51
2. Van Staa TP et al. (2003) Bone density threshold and other predictors of vertebral fracture in patients receiving oral glucocorticoid therapy. Arthritis Rheum 48: 3224-3229
3. Weinstein RS et al. (1998) Inhibition of osteoblastogenesis and promotion of apoptosis of osteoblasts and osteocytes by glucocorticoids: potential mechanisms of their deleterious effects on bone. J Clin Invest 102: 274-282
4. O'Brien CA et al. (2004) Glucocorticoids act directly on osteoblasts and osteocytes to induce their apoptosis and reduce bone formation and strength. Endocrinology 145: 1835-1841
5. Weinstein RS (2001) Glucocorticoid-induced osteoporosis. Rev Endocr Metab Disord 2: 65-73