Synthesis of potent bicyclic bisarylimidazole c-Jun N-terminal kinase inhibitors by catalytic C-H bond activation

Journal of the American Chemical Society

Volumn 129, Issue 3, 2007, Pages 490-491

  Rech, Jason C ^a   Yato, Michihisa ^a   Duckett, Derek ^c   Ember, Brian ^c   LoGrasso, Philip V ^c   Bergman, Robert G ^b   Ellman, Jonathan A ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b LAWRENCE BERKELEY NATIONAL LABORATORY   (United States)

^c SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BICYCLO COMPOUND; IMIDAZOLE DERIVATIVE; POLYCYCLIC AROMATIC HYDROCARBON DERIVATIVE; STRESS ACTIVATED PROTEIN KINASE INHIBITOR;

ANNULATION REACTION; ARTICLE; BROMINATION; CATALYSIS; CYCLIZATION; CYCLOADDITION; DIASTEREOISOMER; DRUG POTENCY; DRUG SYNTHESIS; HYDROGEN BOND; ISOMERIZATION; QUANTUM YIELD; REACTION ANALYSIS; REDUCTION; STILLE REACTION;

BICYCLO COMPOUNDS, HETEROCYCLIC; BINDING SITES; ENZYME INHIBITORS; IMIDAZOLES; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MODELS, CHEMICAL;

EID: 33846443637     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja0676004     Document Type: Article

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