Elevated platelet vesicular monoamine transporter 2 in former heroin addicts maintained on methadone

Journal of Neural Transmission

Volumn 114, Issue 2, 2007, Pages 281-284

  Schwartz, K ^a   Herman, I ^b   Peer, G ^b   Weizman, A ^a   Rehavi, M ^a  

^a TEL AVIV UNIVERSITY   (Israel)

^b Jaffa Ctr Treatm Drug Dependent P   (Israel)

Author keywords

Dihydrotetrabenazine (TBZOH); Heroin; Methadone; Opioids; Platelet; Vesicular monoamine transporter (VMAT2)

Indexed keywords

DIHYDROTETRABENAZINE; METHADONE; VESICULAR MONOAMINE TRANSPORTER 2;

ADULT; ARTICLE; BINDING AFFINITY; BINDING SITE; CLINICAL ARTICLE; CONTROLLED STUDY; DRUG EXPOSURE; HEROIN DEPENDENCE; HUMAN; MALE; PRIORITY JOURNAL; STATISTICAL SIGNIFICANCE; THROMBOCYTE;

BLOOD PLATELETS; HEROIN DEPENDENCE; HUMANS; MALE; METHADONE; MIDDLE AGED; NARCOTICS; VESICULAR MONOAMINE TRANSPORT PROTEINS;

EID: 33846436135     PISSN: 03009564     EISSN: 14351463     Source Type: Journal    
DOI: 10.1007/s00702-006-0527-1     Document Type: Article

References (24)

1. MM Bradford 1976 A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding Anal Biochem 72 248 254
2. 125I]azidoiodoketanserin photoaffinity labeling of the monoamine transporter of platelet 5-HT organelles Eur J Pharmacol 186 95 104
3. G Di Chiara A Imperato 1988 Drugs abused by humans preferentially increase synaptic dopamine concentrations in the mesolimbic system of freely moving rats Proc Natl Acad Sci USA 85 5274 5278
4. RH Edwards 1992 The transport of neurotransmitters into synaptic vesicles Curr Opin Neurobiol 2 586 594
5. C Gerada 2005 Drug misuse: a review of treatments Clin Med 5 69 73
6. SE Hemby TJ Martin C Co SI Dworkin JE Smith 1995 The effects of intravenous heroin administration on extracellular nucleus accumbens dopamine concentrations as determined by in vivo microdialysis J Pharmacol Exp Ther 273 591 598
7. 2 J Neurosci 20 2131 2141
8. M Holtje S Winter D Walther I Pahner H Hortnagl OP Ottersen M Bader G Ahnert-Hilger 2003 The vesicular monoamine content regulates VMAT2 activity through Galphaq in mouse platelets. Evidence for autoregulation of vesicular transmitter uptake J Biol Chem 278 15850 15858
9. SW Johnson RA North 1992 Opioids excite dopamine neurons by hyperpolarization of local interneurons J Neurosci 12 483 488
10. SJ Kish KS Kalasinsky P Derkach GA Schmunk M Guttman L Ang 2001 Striatal dopaminergic and serotonergic markers in human heroin users Neuropsychopharmacology 24 561 567
11. T Macedo CA Ribeiro D Cotrim P Tavares MT Morgadinho M Caramona 1995 Catecholamine and MHPG plasma levels, platelet MAO activity, and 3H-imipramine binding in heroin and cocaine addicts Mol Neurobiol 11 21 29
12. NP Murphy HA Lam Z Chen JE Pintar NT Maidment 2002 Heroin-induced locomotion and mesolimbic dopamine release is unchanged in mice lacking the ORL.1 receptor gene Brain Res 953 276 280
13. HO Pettit A Ettenberg FE Bloom GF Koob 1984 Destruction of dopamine in the nucleus accumbens selectively attenuates cocaine but not heroin self-administration in rats Psychopharmacology (Berl) 84 167 173
14. LG Schmidt P Dufeu A Heinz S Kuhn H Rommelspacher 1997 Serotonergic dysfunction in addiction: effects of alcohol, cigarette smoking and heroin on platelet 5-HT content Psychiatry Res 72 177 185
15. K Schwartz I Iancu R Stryjer J Chelben M Kotler A Weizman M Rehavi 2005a Reduced platelet vesicular monoamine transporter density in smoking schizophrenia patients Eur Neuropsychopharmacol 15 557 561
16. K Schwartz A Weizman M Rehavi 2005b Decreased platelet vesicular monoamine transporter density in habitual smokers Eur Neuropsychopharmacol 15 235 238
17. TS Shippenberg A Herz R Spanagel R Bals-Kubik C Stein 1992 Conditioning of opioid reinforcement: neuroanatomical and neurochemical substrates Ann N Y Acad Sci 654 347 356
18. R Spanagel F Weiss 1999 The dopamine hypothesis of reward: past and current status Trends Neurosci 22 521 527
19. CK Surratt AM Persico X Yang SR Gar GS Bird AL Hawkins CA Griffin X Li EW Jabs GR Uhl 1993 A human synaptic vesicle monoamine transporter cDNA predicts posttranslational modifications, reveals chromosome 10 gene localization and identifies TaqI RFLPs FEBS Lett 318 325 330
20. RA Wise MA Bozarth 1982 Action of drugs of abuse on brain reward systems: an update with specific attention to opiates Pharmacol Biochem Behav 17 239 243
21. RA Wise PP Rompre 1989 Brain dopamine and reward Annu Rev Psychol 40 191 225
22. JK Zubieta P Huguelet LE Ohl RA Koeppe MR Kilbourn JM Carr 2000 High vesicular monoamine transporter binding in asymptomatic bipolar I disorder: sex differences and cognitive correlates Am J Psychiatry 157 1619 1628
23. JK Zubieta SF Taylor P Huguelet RA Koeppe MR Kilbourn KA Frey 2001 Vesicular monoamine transporter concentrations in bipolar disorder type I, schizophrenia, and healthy subjects Biol Psychiatry 49 110 116
24. 3H]TBZOH binding to the human platelet vesicular monoamine transporter Life Sci 69 2311 2317