Sensitive determination of aspirin and its metabolites in plasma by LC-UV using on-line solid-phase extraction with methylcellulose-immobilized anion-exchange restricted access media

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 846, Issue 1-2, 2007, Pages 132-138

  Yamamoto, Eiichi ^a   Takakuwa, Susumu ^a   Kato, Takashi ^a   Asakawa, Naoki ^a  

^a EISAI CO LTD   (Japan)

Author keywords

Anion exchanger; Aspirin; Pharmacokinetics; Plasma; Restricted access media; Solid phase extraction

Indexed keywords

EXTRACTION; ION EXCHANGE; LIQUID CHROMATOGRAPHY; METABOLITES; PLASMAS; ULTRAVIOLET DETECTORS;

ANION EXCHANGERS; ASPIRIN; RESTRICTED ACCESS MEDIA; SOLID PHASE EXTRACTION;

DRUG PRODUCTS;

2,3 DIHYDROXYBENZOIC ACID; ACETYLSALICYLIC ACID; DRUG METABOLITE; GENTISIC ACID; METHYLCELLULOSE; SALICYLIC ACID;

ACCURACY; ANIMAL EXPERIMENT; ANION EXCHANGE; ARTICLE; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG DETERMINATION; LIQUID CHROMATOGRAPHY; MALE; NONHUMAN; ONLINE ANALYSIS; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RAT; SOLID PHASE EXTRACTION; ULTRAVIOLET SPECTROSCOPY; VALIDATION STUDY;

ANIMALS; ANION EXCHANGE RESINS; ASPIRIN; CHROMATOGRAPHY, ION EXCHANGE; MALE; METHYLCELLULOSE; RATS; RATS, SPRAGUE-DAWLEY; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; SPECTROPHOTOMETRY, ULTRAVIOLET;

RATTUS;

EID: 33846434851     PISSN: 15700232     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jchromb.2006.08.037     Document Type: Article

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