Study on simultaneous analysis of six antiepileptic drugs and two active metabolites in human plasma by HPLC

Chinese Pharmaceutical Journal

Volumn 41, Issue 24, 2006, Pages 1899-1902

  Yang, Jie ^a,b   Jiao, Zheng ^a   Shi, Xiao Jin ^a  

^a FUDAN UNIVERSITY   (China)

^b NANJING MEDICAL UNIVERSITY   (China)

Author keywords

Carbamazepine; Carbamazepine 10, 11 epoxide; HPLC; Lamotrigen; Monohydroxycarbazepine; Oxcarbazepine; Phenobarbital; Phenytoin; Primidone

Indexed keywords

ACETONITRILE; CARBAMAZEPINE; CARBAMAZEPINE 10,11 OXIDE; DRUG METABOLITE; LAMOTRIGINE; METHANOL; MONOHYDROXYCARBAZEPINE; OXCARBAZEPINE; PHENOBARBITAL; PHENYTOIN; PRIMIDONE; PROPRANOLOL; TRIFLUOROACETIC ACID; UNCLASSIFIED DRUG;

ARTICLE; DRUG ISOLATION; DRUG METABOLISM; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN TISSUE; PRECIPITATION; VALIDATION PROCESS;

EID: 33846433108     PISSN: 10012494     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (6)

1. JIAO Z, ZHONG M K, SHI X J, et al. Therapeutic drug monitoring of antiepilepsy drugs [J]. Chin Clin Pharmacy, 2004, 13 (6): 386-389.
2. BUGAMELLI F, SABBIONI C, MANDRIOLI R, et al. Simultaneous analysis of six antiepileptic drugs and two selected metabolites in human plasma by liquid chromatography after solid-phase extraction [J]. Anal Chimica Acta, 2002, 472 (1): 1-10.
3. FRANCESCHI L, FURLANUT M. A simple method to monitor plasma concentrations of oxcarbazepine, carbamazepine, their main metabolites and lamotrigine in epileptic patients[J]. Pharmacol Res, 2005, 51 (4): 297-302.
4. LEVERT H, ODOU P, ROBERT H. LC determination of oxcarbazepine and its active metabolite in human serum[J]. J Pharm Biomed Anal, 2002, 28 (3-4): 517-525.
5. TOVD N. Simultaneous determination of eleven antiepileptic compounds in serum by high-performance liquid chromatography [J]. J Chromatogr, 1984, 305(1):127-133.
6. MCDOWALL R D. Sample preparation for biomedical analysis[J]. J Chromatogr, 1989, 492:3-58.