Potential protective effects of zinc in iron overload

Liver International

Volumn 27, Issue 1, 2007, Pages 4-5

  Delima, R ^a   Trinder, D ^a   Olynyk, J K ^a,b,c  

^a UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

^b UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

^c FREMANTLE HOSPITAL   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

IRON; METALLOTHIONEIN; ZINC;

ANTIOXIDANT ACTIVITY; CELL PROTECTION; CHRONIC LIVER DISEASE; CLINICAL FEATURE; DNA DAMAGE; DRUG EFFECT; DRUG INDICATION; DRUG MECHANISM; EDITORIAL; HUMAN; IRON OVERLOAD; LIPID PEROXIDATION; LIVER CIRRHOSIS; NONHUMAN; OXIDATION REDUCTION REACTION; PATHOGENESIS; PROTEIN BINDING; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INTERACTION; PROTEIN LOCALIZATION; WILSON DISEASE;

ANIMALS; ANTIOXIDANTS; BIOLOGICAL TRANSPORT; CARRIER PROTEINS; CATION TRANSPORT PROTEINS; CELL DEATH; CELL LINE; GENE EXPRESSION REGULATION; HEPATOLENTICULAR DEGENERATION; HUMANS; IRON OVERLOAD; RATS; UP-REGULATION; ZINC;

EID: 33846430071     PISSN: 14783223     EISSN: 14783231     Source Type: Journal    
DOI: 10.1111/j.1478-3231.2006.01428.x     Document Type: Editorial

References (12)

1. Persoon-Rothert M, van der Valk-Kokshoom EJ, Egas-Kenniphaas JM, Mauve I, van der Laarse A. Isoproterenol-induced cytotoxicity in neonatal rat heart cell cultures is mediated by free radical formation. J Mol Cell Cardiol 1989; 21: 1285-91.
2. Zhou Z, Wang L, Song Z, Saari JT, McClain CJ, Kang YJ. Zinc supplementation prevents alcoholic liver injury in mice through attenuation of oxidative stress. Am J Pathol 2005; 166: 1681-90.
3. Formigari A, Santon A, Irato P. Efficacy of zinc treatment against iron-induced toxicity in rat hepatoma cell line H4-II-E-C3. LIV 2006.
4. Yamaji S, Tennant J, Tandy S, Williams M, Kaila Singh Srai S, Sharp P. Zinc regulates the function and expression of the iron transporters DMT1 and IREG1 in human intestinal Caco-2 cells. FEBS Lett 2001; 507: 137-41.
5. Tandy S, Williams M, Leggett A, Lopez-Jimenez M, Dedes M, Ramesh B, Srai SK, Sharp P. Nramp2 expression is associated with pH-dependent iron uptake across the apical membrane of human intestinal Caco-2 cells. J Biol Chem 2000; 275: 1023-9.
6. Sacher A, Cohen A, Nelson N. Properties of the mammalian and yeast metal-ion transporters DCT1 and Smf1p expressed in Xenopus laevis oocytes. J Exp Biol 2001; 204: 1053-61.
7. Liuzzi JP, Aydemir F, Nam H, Knutson MD, Cousins RJ. Zip14 (Slc39a14) mediates non-transferrin-bound iron uptake into cells. Proc Natl Acad Sci USA 2006; 103: 13612-7.
8. Liuzzi JP, Cousins RJ. Mammalian zinc transporters. Annu Rev Nutr 2004; 24: 151-72.
9. Andrews GK. Regulation of metallothionein gene expression by oxidative stress and metal ions. Biochem Pharmacol 2000; 59: 95-104.
10. Perez MJ, Cederbaum AI. Metallothionein 2A induction by zinc protects HEPG2 cells against CYP2E1-dependent toxicity. Free Radic Biol Med 2003; 34: 443-55.
11. Farinati F, Cardin R, D'Inca R, Naccarato R, Sturniolo GC. Zinc treatment prevents lipid peroxidation and increases glutathione availability in Wilson's disease. J Lab Clin Med 2003; 141: 372-7.
12. Dabbagh AJ, Mannion T, Lynch SM, Frei B. The effect of iron overload on rat plasma and liver oxidant status in vivo. Biochem J 1994; 300(Part 3): 799-803.