Forelimb movements and muscle responses evoked by microstimulation of cervical spinal cord in sedated monkeys

Journal of Neurophysiology

Volumn 97, Issue 1, 2007, Pages 110-120

  Moritz, Chet T ^a   Lucas, Timothy H ^a   Perlmutter, Steve I ^a   Fetz, Eberhard E ^a,b  

^a UNIVERSITY OF WASHINGTON   (United States)

^b UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

KETAMINE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BODY REGIONS; CERVICAL SPINAL CORD; ELECTROMYOGRAM; ELECTROSTIMULATION; FEMALE; FORELIMB; LIMB MOVEMENT; MALE; MONKEY; MUSCLE CONTRACTION; NONHUMAN; PRIORITY JOURNAL; STIMULUS RESPONSE;

ACTION POTENTIALS; ANIMALS; CERVICAL VERTEBRAE; ELECTRIC STIMULATION; ELECTROMYOGRAPHY; FEMALE; FORELIMB; HYPNOTICS AND SEDATIVES; INTERNEURONS; JOINTS; MACACA NEMESTRINA; MALE; MOTOR NEURONS; MOVEMENT; MUSCLE CONTRACTION; MUSCLE, SKELETAL; NERVE FIBERS, MYELINATED; NEURAL PATHWAYS; NEURONS; POSTERIOR HORN CELLS; RANGE OF MOTION, ARTICULAR; SPINAL CORD;

EID: 33846428462     PISSN: 00223077     EISSN: 15221598     Source Type: Journal    
DOI: 10.1152/jn.00414.2006     Document Type: Article

References (37)

1. Aoyagi Y, Mushahwar VK, Stein RB, Prochazka A. Movements elicited by electrical stimulation of muscles, nerves, intermediate spinal cord, and spinal roots in anesthetized and decerebrate cats. IEEE Trans Neural Syst Rehabil Eng 12: 1-11, 2004.
2. Asanuma H, Rosen I. Topographical organization of cortical efferent zones projecting to distal forelimb muscles in the monkey. Exp Brain Res 14: 243-256, 1972.
3. Belhaj-Saif A, Karrer JH, Cheney PD. Distribution and characteristics of poststimulus effects in proximal and distal forelimb muscles from red nucleus in the monkey. J Neurophysiol 79: 1777-1789, 1998.
4. Brockmeyer DM, Kendig JJ. Selective effects of ketamine on amino acid-mediated pathways in neonatal rat spinal cord. Br J Anaesth 74: 79-84, 1995.
5. Cheney PD, Fetz EE. Comparable patterns of muscle facilitation evoked by individual corticomotoneuronal (CM) cells and by single intracortical microstimuli in primates: evidence for functional groups of CM cells. J Neurophysiol 53: 786-804, 1985.
6. Clough JFM, Kernell D, Phillips CG. The distribution of monosynaptic excitation from the pyramidal tract and from primary spindle afferents to motoneurons of the baboon's hand and forearm. J Physiol 198: 145-166, 1968.
7. Gaunt RA, Prochazka A, Mushahwar VK, Guevrement L, Ellaway PH. Intraspinal microstimulation excites multisegmental sensory afferents at lower stimulus levels than α-motorneurons. J Neurophysiol 96: 2995-3005, 2006.
8. Giszter SF, Loeb E, Mussa-Ivaldi FA, Bizzi E. Repeatable spatial maps of a few force and joint torque patterns elicited by microstimulation applied throughout the lumbar spinal cord of the spinal frog. Hum Move Sci 19: 597-626, 2000.
9. Giszter SF, Mussa-Ivaldi FA, Bizzi E. Convergent force fields organized in the frog's spinal cord. J Neurosci 13: 467-491, 1993.
10. Grill WM, Lemay MA. Hindlimb motor responses evoked by dual-electrode intraspinal microstimulation in the cat. Proc Int Funct Elec Stimul Soc (IFESS) Annu Conf 2002.
11. Gustafsson B, Jankowska E. Direct and indirect activation of nerve cells by electrical pulses applied extracellularly. J Physiol 258: 33-61, 1976.
12. Illert M, Kummel H. Reflex pathways from large muscle spindle afferents and recurrent axon collaterals to motoneurones of wrist and digit muscles: a comparison in cats, monkeys and humans. Exp Brain Res 128: 13-19, 1999.
13. Jankowska E, Roberts WJ. Synaptic actions of single interneurones mediating reciprocal Ia inhibition of motoneurones. J Physiol 222: 623-642, 1972.
14. Jenny AB, Inukai J. Principles of motor organization of the monkey cervical spinal cord. J Neurosci 3: 567-575, 1983.
15. Johnson RA, Wichern DW. Applied Multivariate Statistical Analysis. Englewood Cliffs, NJ: Prentice Hall, 1992.
16. Kendig JJ. In vitro networks: subcortical mechanisms of anaesthetic action. Br J Anaesth 89: 91-101, 2002.
17. Kwan HC, MacKay WA, Murphy JT, Wong YC. Spatial organization of precentral cortex in awake primates. II. Motor outputs. J Neurophysiol 41: 1120-1131, 1978.
18. Lawrence DG, Porter R, Redman SJ. Corticomotoneuronal synapses in the monkey: light microscopic localization upon motoneurons of intrinsic muscles of the hand. J Comp Neurol 232: 499-510, 1985.
19. Lemay MA, Grill WM. Modularity of motor output evoked by intraspinal microstimulation in cats. J Neurophysiol 91: 502-514, 2004.
20. Lodge D, Anis NA. Effects of ketamine and three other anaesthetics on spinal reflexes and inhibitions in the cat. Br J Anaesth 56: 1143-1151, 1984.
21. Mushahwar VK, Aoyagi Y, Stein RB, Prochazka A. Movements generated by intraspinal microstimulation in the intermediate gray matter of the anesthetized, decerebrate, and spinal cat. Can J Physiol Pharmacol 82: 702-714, 2004.
22. Mushahwar VK, Collins DF, Prochazka A. Spinal cord microstimulation generates functional limb movements in chronically implanted cats. Exp Neurol 163: 422-429, 2000.
23. Mushahwar VK, Gillard DM, Gauthier MJ, Prochazka A. Intraspinal micro stimulation generates locomotor-like and feedback-controlled movements. IEEE Trans Neural Syst Rehabil Eng 10: 68-81, 2002.
24. Mushahwar VK, Horch KW. Proposed specifications for a lumbar spinal cord electrode array for control of lower extremities in paraplegia. IEEE Trans Rehabil Eng 5: 237-243, 1997.
25. Mushahwar VK, Horch KW. Selective activation and graded recruitment of functional muscle groups through spinal cord stimulation. Ann NY Acad Sci 860: 531-535, 1998.
26. Mushahwar VK, Horch KW. Selective activation of muscle groups in the feline hindlimb through electrical microstimulation of the ventral lumbosacral spinal cord. IEEE Trans Rehabil Eng 8: 11-21, 2000.
27. Mussa-Ivaldi FA, Giszter SF, Bizzi E. Linear combinations of primitives in vertebrate motor control. Proc Natl Acad Sci USA 91: 7534 -7538, 1994.
28. Park MC, Belhaj-Saif A, Cheney PD. Properties of primary motor cortex output to forelimb muscles in rhesus macaques. J Neurophysiol 92: 2968-2984, 2004.
29. Perlmutter SI, Maier MA, Fetz EE. Activity of spinal interneurons and their effects on forearm muscles during voluntary wrist movements in the monkey. J Neurophysiol 80: 2475-2494, 1998.
30. Poliakov AV, Schieber MH. Limited functional grouping of neurons in the motor cortex hand area during individuated finger movements: a cluster analysis. J Neurophysiol 82: 3488-3505, 1999.
31. Porter R, Hore J. Time course of minimal corticomotoneuronal excitatory postsynaptic potentials in lumbar motoneurons of the monkey. J Neurophysiol 32: 443-451, 1969.
32. Porter R, Lemon RN. Corticospinal Function and Voluntary Movement: Oxford, UK: Oxford Univ. Press, 1993.
33. Prochazka A, Mushahwar VK, Yakovenko S. Activation and coordination of spinal motoneuron pools after spinal cord injury. In: Neural Repair and Recovery, edited by McKerracher L, Douchet G, Rossignol S. Amsterdam: Elsevier, 2002, p. 109-124.
34. Ranck JB Jr. Which elements are excited in electrical stimulation of mammalian central nervous system: a review. Brain Res 98: 417- 440, 1975.
35. Rosen I, Asanuma H. Peripheral afferent inputs to the forelimb area of the monkey motor cortex: input-output relations. Exp Brain Res 14: 257-273, 1972.
36. Saigal R, Renzi C, Mushahwar VK. Intraspinal microstimulation generates functional movements after spinal-cord injury. IEEE Trans Neural Syst Rehabil Eng 12: 430-440, 2004.
37. Tresch MC, Bizzi E. Responses to spinal microstimulation in the chronically spinalized rat and their relationship to spinal systems activated by low threshold cutaneous stimulation. Exp Brain Res 129: 401-416, 1999.