Association of platelet-monocyte aggregates with platelet activation, systemic inflammation, and myocardial injury in patients with non-ST elevation acute coronary syndromes

Clinical Cardiology

Volumn 30, Issue 1, 2007, Pages 26-31

  Zhang, Song Zhao ^a   Jin, Ya Ping ^a   Qin, Guang Ming ^a   Wang, Jun Hong ^b  

^a THE SECOND AFFILIATED HOSPITAL OF ZHEJIANG UNIVERSITY SCHOOL OF MEDICINE   (China)

^b THE FIRST AFFILIATED HOSPITAL OF NANJING MEDICAL UNIVERSITY   (China)

Author keywords

Acute coronary syndromes; Inflammation; Platelet monocyte aggregates; Troponin I

Indexed keywords

BIOLOGICAL MARKER; C REACTIVE PROTEIN; CD40 LIGAND; INTERLEUKIN 6; PADGEM PROTEIN; TROPONIN I;

ACUTE CORONARY SYNDROME; ADULT; AGED; ARTICLE; BLOOD LEVEL; CELL AGGREGATION; CONTROLLED STUDY; CORONARY ARTERY DISEASE; CORRELATION ANALYSIS; DISEASE ASSOCIATION; FEMALE; HEART INFARCTION; HEART MUSCLE INJURY; HOSPITAL ADMISSION; HUMAN; INFLAMMATION; LABORATORY DIAGNOSIS; MAJOR CLINICAL STUDY; MALE; MEASUREMENT; MONOCYTE; NON ST ELEVATION ACUTE CORONARY SYNDROME; PARAMETER; RISK ASSESSMENT; STABLE ANGINA PECTORIS; THROMBOCYTE ACTIVATION; THROMBOCYTE AGGREGATION;

AGED; ANGINA PECTORIS; BIOLOGICAL MARKERS; C-REACTIVE PROTEIN; CELL AGGREGATION; CORONARY ARTERY DISEASE; FEMALE; HUMANS; INFLAMMATION; INFLAMMATION MEDIATORS; MALE; MIDDLE AGED; MONOCYTES; MYOCARDIAL INFARCTION; PLATELET ACTIVATION; PLATELET AGGREGATION; PREDICTIVE VALUE OF TESTS; TROPONIN I;

EID: 33846419162     PISSN: 01609289     EISSN: None     Source Type: Journal    
DOI: 10.1002/clc.2     Document Type: Article

References (20)

1. Libby P: Current concepts of the pathogenesis of the acute coronary syndromes. Circulation 2001;104;365-372
2. Libby P: Molecular bases of the acute coronary syndromes. Circulation 1995;91:2844-2850
3. Libby P, Ridker PM, Maseri A: Inflammation and atherosclerosis. Circulation 2002;105:1135-1143
4. Ridker PM, Cushman M, Stampfer MJ, Tracy RP, Hennekens CH: Plasma concentration of C-reactive protein and risk of developing peripheral vascular disease. Circulation 1998;97:425-428
5. McGregor L, Martin J, McGregor JL: Platelet-leukocyte aggregates and derived microparticles in inflammation, vascular remodelling and thrombosis. Front Biosci 2006;11:830-837
6. Vandendries ER, Furie BC, Furie B: Role of P-selectin and PSGL-1 in coagulation and thrombosis. Thromb Haemost 2004;92:459-466
7. Sarma J, Laan CA, Alam S, Jha A, Fox KA, et al.: Increased platelet binding to circulating monocytes in acute coronary syndromes. Circulation 2002;105:2166-2171
8. Furman MI, Barnard MR, Krueger LA, Fox ML, Shilale EA, et al.: Circulating monocyte-platelet aggregates are an early marker of acute myocardial infarction. J Am Coll Cardiol 2001;38:1002-1006
9. Faraday N, Braunstein JB, Heldman AW, Bolton ED, Chiles KA, et al.: Prospective evaluation of the relationship between platelet-leukocyte conjugate formation and recurrent myocardial ischemia in patients with acute coronary syndromes. Platelets 2004;15:9-14
10. Freedman JE, Loscalzo J: Platelet-monocyte aggregates: Bridging thrombosis and inflammation. Circulation 2002;105:2130-2132
11. Wang JH, Qin GM, Zhang SZ, Jin Y-P: Efficient measurement of platelet-monocyte aggregates in whole blood by flow cytometry. J Chin Lab Med 2005;28:1288-1291
12. Myocardial infarction redefined-A consensus document of the Joint European Society of Cardiology/American College of Cardiology Committee for the Redefinition of Myocardial Infarction. J Am Coll Cardiol 2000;36:959-968
13. Grundy SM, Cleeman JI, Bairey Merz CN, Brewer HB Jr, Clark LT, et al.: Implications of recent clinical trials for the National Cholesterol Education Program Adult Treatment Panel III guidelines. Circulation 2004;110:227-239
14. Morrow D, Rifai N, Sabatine M: Evaluation of the AccuTnI cardiac troponin assay for risk assessment in acute coronary syndromes. Clin Chem 2003;49:1396-1398
15. Morrow DA, Rifai N, Antman EM, Weiner DL, McCabe CH, et al.: C-reactive protein is a potent predictor of mortality independently of and in combination with troponin T in acute coronary syndromes: A TIMI 11A substudy. Thrombolysis in Myocardial Infarction. J Am Coll Cardiol 1998;31:1460-1465
16. Jialal I, Devaraj S, Senthil K: C-reactive protein: Risk marker or mediator in atherothrombosis? Hypertension 2004;44:6-11
17. Ferreriros ER, Boissonnet CP, Pizarro R, García PF, Corrado G, et al.: Independent prognostic value of elevated C-reactive protein in unstable angina. Circulation 1999;100:1958-1963
18. Heeschen C, Hamm CH, Bruemmer J, Simoons ML: Predictive value of C-reactive protein and troponin T in patients with unstable angina: A comparative analysis. J Am Coll Cardiol 2000;35:1535-1542
19. Lindahl B, Toss H, Siegbahn A, Venge P, Wallentin L: Markers of myocardial damage and inflammation in relation to long-term mortality in unstable coronary artery disease. N Engl J Med 2000;343:1139-1147
20. Xiao ZH, Théroux P: Clopidogrel inhibits platelet-leukocyte interactions and thrombin receptor agonist peptide-induced platelet activation in patients with an acute coronary syndrome. J Am Coll Cardiol 2004;43:1982-1988