End-of-treatment (EOT) response in therapy-naïve patients treated for chronic hepatitis C with viramidine in combination with pegylated interferon alfa-2a
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The safety and efficacy of Viramidine® plus pegylated interferon alfa-2b versus ribavirin plus pegylated interferon alfa-2b in therapy-naïve patients infected with HCV: Phase 3 results
[abstract #751]. Presented at the Vienna, Austria
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Initial results of a phase 1B, multiple dose study of VX-950, a hepatitis C virus protease inhibitor
Reesink HW et al. (2005) Initial results of a phase 1B, multiple dose study of VX-950, a hepatitis C virus protease inhibitor. Gastroenterology 128 (Suppl): A-697
Final results of a phase 1B, multiple-dose study of VX-950, a hepatitis C virus protease inhibitor
Reesink HW et al. (2005) Final results of a phase 1B, multiple-dose study of VX-950, a hepatitis C virus protease inhibitor. Hepatology 42 (Suppl 1): 234A-235A
Vertex successfully completes key studies with VX-950 to prepare for next steps in clinical program
Vertex Pharmaceuticals Incorporated (accessed July 7 2006)
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28 days of the hepatitis C protease C inhibitor VX-950, in combination with peginterferon-alfa-2a and ribavirin, is well-tolerated and demonstrates robust antiviral effects
[abstract #686f]
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Anti-viral activity of SCH 503034, a HCV protease inhibitor, administered as monotherapy in hepatitis C genotype-1 (HCV-1) patients refractory to pegylated interferon (PEG-IFN-α)
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Modeling of hepatitis C viral dynamics during combination therapy with peginterferon alfa-2B (peg-intron) and the NS3 protease inhibitor SCH 503034
[abstract #1266]. Presented at the San Francisco, CA
Malcolm BA (2005) Modeling of hepatitis C viral dynamics during combination therapy with peginterferon alfa-2B (peg-intron) and the NS3 protease inhibitor SCH 503034 [abstract #1266]. Presented at the Annual Meeting of the American Association for the Study of Liver Disease: 2005 November 11-15; San Francisco, CA
Control of antiviral defenses through hepatitis C virus disruption of retinoic acid-inducible gene-I signaling
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Pharmacokinetic boosting of VX-950, an inhibitor of HCV protease, by co-dosing with ritanovir
[abstract #4]. Presented at the Vienna, Austria
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Valopicitabine (nm283) alone and in combination with peg-interferon in patients with genotype 1 chronic hepatitis C: Preliminary results from an ongoing phase II, multicenter study
Rodriguez-Torres M (2005) Valopicitabine (nm283) alone and in combination with peg-interferon in patients with genotype 1 chronic hepatitis C: Preliminary results from an ongoing phase II, multicenter study. Gastroenterology 128 (Suppl): A-695
HCV antiviral resistance: The impact of in vitro studies on the development of antiviral agents targeting the viral NS5B polymerase
Tomei L et al. (2005) HCV antiviral resistance: The impact of in vitro studies on the development of antiviral agents targeting the viral NS5B polymerase. Antivir Chem Chemother 16: 225-245