Iridium-catalyzed conversion of alcohols into amides via oximes

Organic Letters

Volumn 9, Issue 1, 2007, Pages 73-75

  Owston, Nathan A ^a   Parker, Alexandra J ^b   Williams, Jonathan M J ^a  

^a University of Bath Claverton Down   (United Kingdom)

^b ASTRAZENECA   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOL DERIVATIVE; AMIDE; IRIDIUM; OXIME;

ARTICLE; CATALYSIS; CHEMICAL STRUCTURE; CHEMISTRY; OXIDATION REDUCTION REACTION;

ALCOHOLS; AMIDES; CATALYSIS; IRIDIUM; MOLECULAR STRUCTURE; OXIDATION-REDUCTION; OXIMES;

EID: 33846406900     PISSN: 15237060     EISSN: None     Source Type: Journal    
DOI: 10.1021/ol062549u     Document Type: Article

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20. 3) via syringe, and the mixture was heated at reflux. The reaction was allowed to cool to room temperature and hydroxylamine hydrochloride (36.2 mg, 1 mmol) added. The vessel was flushed with nitrogen and the mixture further refluxed for 16 h. The reaction was allowed to cool to room temperature, diluted with dichloromethane, and filtered through a short plug of silica gel, and the solvent was removed in vacuo. The crude product was purified by column chromatography on silica gel or recrystallization from suitable solvent