Design, synthesis, and evaluation of [188Re]organorhenium- labeled antibody fragments with renal enzyme-cleavable linkage for low renal radioactivity levels

Bioconjugate Chemistry

Volumn 18, Issue 1, 2007, Pages 190-198

  Uehara, Tomoya ^a   Koike, Miho ^a   Nakata, Hideo ^a   Hanaoka, Hiroshi ^b   Iida, Yasuhiko ^b   Hashimoto, Kazuyuki ^c   Akizawa, Hiromichi ^a   Endo, Keigo ^b   Arano, Yasushi ^a  

^a CHIBA UNIVERSITY   (Japan)

^b GUNMA UNIVERSITY   (Japan)

^c JAPAN ATOMIC ENERGY AGENCY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODIES; CELL MEMBRANES; ENZYMES; HYDROLYSIS; RADIATION; RADIOACTIVITY; RHENIUM COMPOUNDS;

ANTIBODY-FRAGMENT; BIODISTRIBUTIONS; BRUSH BORDER MEMBRANES VESICLES; FAB' FRAGMENT; METALLICS; METALLOENZYMES; MOLECULAR DESIGN; PEPTIDE LINKAGES; RADIOACTIVITY LEVEL; RADIOMETAL CHELATES;

AMINO ACIDS;

3' IODOHIPPURYL N EPSILON MALEOYLLYSINE; AMINO ACID DERIVATIVE; CYCLOPENTANE DERIVATIVE; GLYCINE DERIVATIVE; IMMUNOGLOBULIN F(AB) FRAGMENT; IODINE 125; IODINE 131; IODOHIPPURATE SODIUM I 125; LYSINE DERIVATIVE; N EPSILON MALEOYLGLYCYLLYSINE; N EPSILON TERT BUTOXYCARBONYLGLYCYLLYSINE; ORGANOMETALLIC COMPOUND; RHENIUM 188; TRICARBONYL(CYCLOPENTADIENYLCARBONATE)RHENIUM; TRICARBONYL(CYCLOPENTADIENYLCARBONYLGLYCYL N EPSILON MALEOYLLYSINE)RHENIUM; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRUSH BORDER; CANCER RADIOTHERAPY; ISOTOPE LABELING; KIDNEY; KIDNEY CORTEX; MEMBRANE VESICLE; MOUSE; NONHUMAN; RADIOACTIVITY; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; STOMACH CANCER; SYNTHESIS; TISSUE DISTRIBUTION; URINARY EXCRETION;

MUS; RATTUS;

EID: 33846405267     PISSN: 10431802     EISSN: None     Source Type: Journal    
DOI: 10.1021/bc0602329     Document Type: Article

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