Action potential and QT prolongation not sufficient to cause Torsade de Pointes: Role of action potential triangulation

Journal of Cardiovascular Electrophysiology

Volumn 18, Issue 2, 2007, Pages 204-205

  Grant, Augustus O ^a,c   Tranquillo, Joseph ^b  

^a DUKE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b BUCKNELL UNIVERSITY   (United States)

^c DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMIODARONE; DOFETILIDE; QUINIDINE;

GUINEA PIG; HEART DEPOLARIZATION; HEART MUSCLE CELL; HEART MUSCLE POTENTIAL; HEART PROARRHYTHMIA; HEART REPOLARIZATION; HUMAN; MEDICAL LITERATURE; NONHUMAN; NOTE; PRIORITY JOURNAL; PUBLICATION; QT INTERVAL; QT PROLONGATION; RABBIT; RR INTERVAL; SHORT QT SYNDROME; SYNCOPE; TORSADE DES POINTES;

ACTION POTENTIALS; ANIMALS; ANTI-ARRHYTHMIA AGENTS; ARRHYTHMIA; CALCIUM CHANNEL BLOCKERS; CALCIUM CHANNELS, L-TYPE; GUINEA PIGS; IMIDAZOLIDINES; MYOCYTES, CARDIAC; NICARDIPINE; PATCH-CLAMP TECHNIQUES; PHENETHYLAMINES; PIPERAZINES; RABBITS; SULFONAMIDES; TORSADES DE POINTES;

EID: 33846382716     PISSN: 10453873     EISSN: 15408167     Source Type: Journal    
DOI: 10.1111/j.1540-8167.2007.00726.x     Document Type: Note

References (8)

1. Roden DM: Drug-induced prolongation of the QT interval. N Engl J Med 2004;350:1013-1022.
2. Hondeghem LM, Carlsson L Duker G: Instability and triangulation of the action potential predict serious proarrhythmia, but action potential duration prolongation is antiarrhythmic. Circulation 2001;103:2004-2013.
3. Hondeghem LM: Thorough QT/QTc not so thorough: Removes torsadogenic predictors from the T-wave, incriminates safe drugs, and misses profibrillatory drugs. J Cardiovasc Electrophysiol 2006;17:337-340.
4. Valentin J-P, Hoffmann P, De Clerck F, Hammond TG Hondeghem L: Review of the predictive value of the Langendorff heart model (Screenit system) in assessing the proarrhythmic potential of drugs. J Pharmacol Toxicol Methods 2004;49:171-181.
5. January CT, Riddle JM: Early afterdepolarizations: Mechanism of induction and block. Circ Res 1989;64:977-990.
6. Viswanathan PC, Rudy Y: Pause induced early afterdepolarizations in the long QT syndrome: A simulation study. Cardiovasc Res 1999;42:530-542.
7. Zeng J, Rudy Y: Early afterdepolarizations in cardiac myocytes: Mechanism and rate dependence. Biophys J 1995;68:949-964.
8. Guo D, Zhao X, Wu Y, Liu T, Kowey PR, Yan G-X: L-type calcium current reactivation contributes to arrhythmogenesis associated with action potential triangulation. J Cardiovasc Electrophysiol 2007;18:196-203.