Acute and subacute toxicity studies of Aegle marmelos Corr., an Indian medicinal plant

Phytomedicine

Volumn 14, Issue 2-3, 2007, Pages 209-215

  Veerappan, A ^a,b   Miyazaki, S ^b   Kadarkaraisamy, M ^c   Ranganathan, D ^a  

^a UNIVERSITY OF MADRAS   (India)

^b NATIONAL INSTITUTE OF ANIMAL HEALTH   (Japan)

^c NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY AIST   (Japan)

Author keywords

Acute toxicity; Aegle marmelos; Drug margin of safety; Indian bael; LD50 values; Subacute toxicity; Therapeutic index

Indexed keywords

AEGLE MARMELOS EXTRACT; ALCOHOL; METHANOL; PLANT EXTRACT;

ACUTE TOXICITY; AEGLE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN; CALCULATION; CONTROLLED STUDY; DRUG SAFETY; DRUG SCREENING; FEMALE; HEART; HISTOPATHOLOGY; INDIAN; KIDNEY; LD 50; LIVER; MALE; MEDICINAL PLANT; NONHUMAN; PLANT LEAF; PRIORITY JOURNAL; RAT; SPLEEN; SYSTOLIC TIME INTERVAL; TESTIS; TOXICITY TESTING; WISTAR RAT;

AEGLE; ANIMALS; FEMALE; INDIA; INJECTIONS, INTRAPERITONEAL; LETHAL DOSE 50; MALE; MEDICINE, TRADITIONAL; ORGAN SIZE; PHYTOTHERAPY; PLANT EXTRACTS; PLANT LEAVES; RATS; RATS, WISTAR; TOXICITY TESTS;

AEGLE MARMELOS; ANIMALIA; RATTUS; RATTUS NORVEGICUS;

EID: 33846370225     PISSN: 09447113     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.phymed.2006.05.004     Document Type: Article

References (24)

1. Amadou C.K. Promoting alternative medicine. Africa Health J. 2 (1998) 20
2. Arseculeratne S.N., Gunatilaka A.A., and Panabokke R.G. Studies on medicinal plants of Sri Lanka. Part 14: toxicity of some traditional medicinal herbs. J. Ethnopharmacol. 13 (1985) 323-335
3. Arul V., Kumaraguru S., and Dhananjayan R. Effects of aegeline and lupeol, the two cardioactive principles isolated from the leaves of Aegle marmelos Corr. J. Pharm. Pharmacol. 51 S (1999) 252
4. Arul V., Miyazaki S., and Dhananjayan R. Mechanisms of the contractile effect of the alcoholic extract of Aegle marmelos Corr on the isolated guinea pig ileum and tracheal chain. Phytomedicine 11 7-8 (2004) 679-683
5. Arul V., Miyazaki S., and Dhananjayan R. Studies on the anti-inflammatory, antipyretic and analgesic properties of the leaves of Aegle marmelos Corr. J. Ethnopharmacol. 96 1-2 (2005) 159-163
6. Banerji N., and Kumar R. Studies on the seed oil of Aegle marmelos and its effects on some bacterial species. J. Inst. Chem. 52 (1980) 59-60
7. Das A.V., Padayatti P.S., and Paulose C.S. Effect of leaf extract of Aegle marmelos (L.) Correa ex Roxb. on histological and ultrastructural changes in tissues of streptozotocin induced diabetic rats. Indian J. Exp. Biol. 34 (1996) 341-345
8. Dymock William C.J., Warden H., and David H. Pharmacographia Indica, A History of the Principal Drugs of Vegetable Origin Met within British India vol. I (1890), Kegan Paul, Trench Trubner and Co. Ltd., London pp. 277-281
9. Haravey S.K. A preliminary communication of the action of Aegle marmelos (Bael) on heart. Indian J. Med. Res. 56 (1968) 327-331
10. Karawya M.S., Mirhom Y.W., and Shehata I.A. Sterols, triterpenes, coumarins and alkaloids of Aegle marmelos Correa, cultivated in Egypt. Egypt. J. Pharm. Sci. 21 (1980) 239-248
11. Karunanayake E.H., Welihinda J., Sirimanne S.R., et al. Oral hypoglycaemic activity of some medicinal plants of Sri Lanka. J. Ethnopharmacol. 11 (1984) 223-231
12. Kingsbury J.M. Poisonous Plants of the United States and Canada (1964), Prentice-Hall, Inc., Englewood Cliffs, NJ, USA
13. Kirtikar K.R., Basu B.D., and ICS. Indian Medicinal Plants. second ed (1935), International Book Distributors, Dehradun, India pp. 448-502
14. Murugesa Mudaliar K.S. Materia Medica of Tamil Systems of Medicine, Part I (1988), Tamil Nadu Siddha Medical Board, Govt. of Tamil Nadu, India pp. 638-642
15. Nadkarni A.K. Dr. K.M. Nadkarni's Indian Materia Medica vol. 1 (1986), Popular Prakashan Company, Bombay, India p. 45
16. Pattnaik S., Subramanyam V.R., and Kale C. Antibacterial and antifungal activity of ten essential oils in vitro. Microbios 86 (1996) 237-246
17. Ponnachan P.T.C., Paulose C.S., and Panikkar K.R. Effect of leaf extract of Aegle marmelos in diabetic rats. Indian J. Exp. Biol. 31 (1993) 345-347
18. Rana B.K., Singh U.P., and Taneja V. Anti-fungal activity and kinetics of inhibition by essential oil isolated from leaves of Aegle marmelos. J. Ethnopharmacol. 57 (1997) 29-34
19. Raza M., Al-Shabanah O.A., El-Hadiyah T.M., and Al-Majed A.A. Effect of prolonged vigabatrin treatment on haematological and biochemical parameters in plasma, liver and kidney of Swiss albino mice. Sci. Pharmaceut. 70 (2002) 135-145
20. Seema P.V., Sudha B., Padayatti P.S., et al. Kinetic studies of purified malate dehydrogenase in liver of streptozotocin-diabetic rats and the effect of leaf extract of Aegle marmelos (L.) Correa ex Roxb. Indian J. Exp. Biol. 34 (1996) 600-602
21. Sofowora A. Medicinal Plant and Traditional Medicine in Africa. second ed (1982), Wiley, Ibadan pp. 8-14
22. Teo S., Stirling D., Thomas S., Hoberman A., Kiorpes A., and Khetani V. A 90-day oral gavage toxicity study of d-methylphenidate and d,l-methylphenidate in Sprague-Dawley rats. Toxicology 179 (2002) 183-196
23. Tofovic S.P., and Jackson E.K. Effects of long-term caffeine consumption on renal function in spontaneously hypertensive heart failure prone rats. J. Cardiovasc. Pharmacol. 33 (1999) 360-366
24. Turner R.A. Screening Methods in Pharmacology (1965), Academic Press, New York pp. 302-304