Pharmacodynamic interaction between atovaquone and other antimalarial compounds against Plasmodium falciparum in vitro

Wiener Klinische Wochenschrift, Supplement

Volumn 118, Issue 3, 2006, Pages 70-76

  Lütgendorf, Carola ^a   Rojanawatsirivet, Chaiporn ^b   Wernsdorfer, Gunther ^c   Sirichaisinthop, Jeeraphat ^b   Kollaritsch, Herwig ^a   Wernsdorfer, Walther H ^a,c  

^a MEDICAL UNIVERSITY OF VIENNA   (Austria)

^b MINISTRY OF PUBLIC HEALTH   (Thailand)

^c MAHIDOL UNIVERSITY   (Thailand)

Author keywords

Artemisinin; Atovaquone; Plasmodium falciparum; Proguanil; Synergism

Indexed keywords

ARTEMISIN; ATOVAQUONE; PROGUANIL;

ARTICLE; DRUG POTENTIATION; DRUG STRUCTURE; IN VITRO STUDY; MALARIA; NONHUMAN; PLASMODIUM FALCIPARUM;

ANIMALS; ANTIMALARIALS; ARTEMISININS; ATOVAQUONE; CHLOROGUANIDE; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG INTERACTIONS; DRUG RESISTANCE, MULTIPLE; DRUG SYNERGISM; HUMANS; LACTONES; PARASITIC SENSITIVITY TESTS; PLASMODIUM FALCIPARUM; SESQUITERPENES; THAILAND;

EID: 33846364704     PISSN: 03005178     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00508-006-0685-z     Document Type: Article

References (21)

1. rd millennium. Wien Klin Wochenschr 115 [Suppl 3]: 2-9
2. Wernsdorfer WH, Trigg PI (1988) Recent progress of malaria research: chemotherapy. In: Wernsdorfer WH, McGregor Sir I (eds) Malaria, principles and practice of malariology, vol 2. Churchill Livingstone, Edinburgh, pp 1569-1674
3. World Health Organization (1973) Chemotherapy of malaria and resistance to antimalarials. WHO Technical Report Series no 529. WHO, Geneva
4. Hudson AT, Randall AW, Fry M, Ginger CD, Hill B, Latter VS, et al (1985) Novel anti-malarial hydroxynaphthoquinones with potent broad spectrum antiprotozoal activity. Parasitology 90: 45-55
5. Hughes W, Leoung G, Kramer F, Bozzette S, Safrin S, Frame P, et al (1993) Comparison of atovaquone (566C 80) with trimethoprim-sulfamethoxazole to treat Pneumocystis carinii pneumonia in patients with AIDS. N Engl J Med 328: 1521-1527
6. Wernsdorfer G, Landgraf B, Kilimali VAEB, Wernsdorfer WH (1995) In vitro sensitivity to atovaquone of Plasmodium falciparum in northeastern Tanzania 1993. Mitt Oesterr Ges Tropenmed Parasitol 17: 229-234
7. Looareesuwan S, Viravan C, Webster HK, Kyle DE, Hutchinson DB, Canfield CJ (1996) Clinical studies of atovaquone, alone or in combination with other antimalarial drugs, for treatment of acute uncomplicated malaria in Thailand Am J Trop Med Hyg 54: 62-66
8. Thapar MM, Gupta S, Spindler C, Wernsdorfer WH, Bjorkman A (2003) Pharmacodynamic interactions among atovaquone, proguanil and cycloguanil Against Plasmodium falciparum in vitro. Trans R Soc Trop Med Hyg 97: 331-337
9. Wichmann O, Muehlen M, Gruss H, Mockenhaupt FP, Surrorp N, Jelinek T (2004) Malarone treatment failure not associated with previously described mutations in the cytochrome b gene. Malar J 3: 14
10. David KP, Alifrangis M, Salanti A, Vestergaard LS, Ronn A, Bygbjerg IB (2003) Atovaquone/proguanil resistance in Africa: a case report. Scand J Infect Dis 35: 897-898
11. van Vugt M, Leonardi E, Paiphun L, Slight T, Thway KL, McGready R, et al (2002) Treatment of uncomplicated multidrug-resistant falciparum malaria with Artesunate-atovaquone-proguanil. Clin Infect Dis 35: 1498-1504
12. Gupta RK, van Vugt M, Paiphun L, Slight T, Looareesuwan S, White NJ, Nosten F (2005) Short report: no evidence of cardiotoxicity of atovaquone-proguanil alone or in combination with artesunate. Am J Trop Med Hyg 73: 267-268
13. Rieckmann KH, Campbell GH, Sax LJ, Mrema JE (1978) Drug sensitivity of Plasmodium falciparum. An in vitro micro technique. Lancet 1: 22-23
14. Wernsdorfer WH (1980) Field evaluation of drug resistance in malaria. In vitro microtest. Acta Tropica 37: 222-227
15. Litchfield JT, Wilcoxon F (1949) A simplified method of evaluating dose-effect experiments. J Pharmacol Exp Ther 96: 99-113
16. Wernsdorfer WH, Wernsdorfer MG (1955) The evaluation of in vitro tests for the assessment of drug reponse in Plasmodium falciparum. Mitt Oesterr Ges Tropenmed Parasitol 17: 221-228
17. Berenbaum MC (1978) A method for testing for synergy with any number of agents. J Infect Dis 137: 122-130
18. Wernsdorfer WH, Wernsdorfer G, Prajakwong S, Woitsch B, Zatloukal C, Kollaritsch H (2000) Activity correlation between artemisinin and dihydroartemisinin in fresh isolates of Plasmodium falciparum from Thailand. Mitt Oesterr Ges Tropenmed Parasitol 22: 87-94
19. Jambou R, Legrand E, Niang M, Khim N, Lim P, Volney P, et al (2005) Resistance of Plasmodium falciparum field isolates to in-vitro artemether and point mutations of the SERCA-type PfATPase6. Lancet 366: 1960-1963
20. Afonso A, Hunt P, Cheesman S, Alves AC, Cunha CV, do Rosario V, Cravo P (2006) Malaria parasites can develop stable resistance to artemisinin but lack mutations in candidate genes atp6 (encoding the sarcoplasmic and endoplasmic reticulum Ca2+ ATPase, tctp, mdr1, and cg10. Antimicrob Agents Chemother 50: 480-489
21. Schmid S (2001) In vitro Sensibilität von Plasmodium falciparum im Nordwesten Thailands gegenüber Atovaquon, Proguanil und Cycloguanil sowie gegenüber den Kombinationen Atovaquon/Proguanil, Atovaquon/Proguanil/Cycloguanil und Proguanil/Cycloguanil. Dissertation, Faculty of Medicine, University of Vienna