Sulpiride plus hydroxyzine decrease tinnitus perception

Auris Nasus Larynx

Volumn 34, Issue 1, 2007, Pages 23-27

  Lopez Gonzalez, Miguel A ^a   Moliner Peiro, Fernando ^b   Alfaro Garcia, Jorge ^b   Esteban Ortega, Francisco ^a  

^a HOSPITAL UNIVERSITARIO VIRGEN DEL ROCÍO   (Spain)

^b Division of Dermatology Quiron Hospital   (Spain)

Author keywords

Dopamine; Hydroxyzine; Neurotransmitters; Sulpiride; Tinnitus

Indexed keywords

HYDROXYZINE; LACTOSE; PLACEBO; SULPIRIDE;

ABSENCE OF SIDE EFFECTS; ADULT; AGED; ARTICLE; AUDIOMETRY; CLINICAL TRIAL; COMBINATION CHEMOTHERAPY; CONSULTATION; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG EFFICACY; EVALUATION; FEMALE; HEARING TEST; HUMAN; MAJOR CLINICAL STUDY; MALE; MONOTHERAPY; OTORHINOLARYNGOLOGY; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL; SINGLE BLIND PROCEDURE; SPAIN; TINNITUS; TREATMENT DURATION; TREATMENT WITHDRAWAL; TYMPANOMETRY; VISUAL ANALOG SCALE;

ADULT; AGED; AGED, 80 AND OVER; DOPAMINE ANTAGONISTS; DRUG ADMINISTRATION SCHEDULE; DRUG THERAPY, COMBINATION; FEMALE; HISTAMINE H1 ANTAGONISTS; HUMANS; HYDROXYZINE; MALE; MIDDLE AGED; PROSPECTIVE STUDIES; SINGLE-BLIND METHOD; SULPIRIDE; TINNITUS;

EID: 33846353276     PISSN: 03858146     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.anl.2006.09.021     Document Type: Article

References (18)

1. Lopez-Gonzalez M.A., and Esteban-Ortega F. Tinnitus dopaminergic pathway. Ear noises treatment by dopamine modulation. Med Hypotheses 65 (2005) 349-352
2. Jastreboff P.J., and Hazell J.W. A neurophysiological approach to tinnitus. Br J Audiol 27 (1993) 7-17
3. Shulman A., Strashun A.M., Afriyie M., Aronson F., Abel W., and Goldstein B. SPECT imaging of brain and tinnitus-neurotologic/neurologic implications. Int Tinnitus J 1 (1995) 13-29
4. Mirz F., Pedersen B., Ishizu K., Johannsen P., Ovesen T., Stodkilde-Jorgensen H., et al. Positron emission tomography of cortical centers of tinnitus. Hear Res 134 (1999) 133-144
5. Mahlke C., and Wallhausser-Franke E. Evidence for tinnitus-related plasticity in the auditory and limbic system, demonstrated by arg3.1 and c-fos immunocytochemistry. Hear Res 195 (2004) 17-34
6. Lopez-Gonzalez M.A., Muratori-Leon M.L., and Moreno-Vaquera J. Sulpiride as initial treatment in the rehabilitation therapy of tinnitus. Acta Otorrinolaringol Esp 54 (2003) 237-241
7. Chung D.Y., Gannon R.P., and Mason K. Factors affecting the prevalence of tinnitus. Audiology 23 (1984) 441-452
8. Farah L. Preliminary study on the use of hydroxyzine in psychosomatic affections. Int Rec Med Gen Pract Clin 169 (1956) 379-389
9. Menger H.C. Use of hydroxyzine (atarax) in the management of ear, nose, and throat disorders. N Y State J Med 58 (1958) 1684-1686
10. Steinberg N., and Holz W.G. Preoperative preparation for tonsillectomy with hydroxyzine hydrochloride in pediatric patients. N Y State J Med 60 (1960) 691-693
11. Ferreri M., and Hantouche E.G. Recent clinical trials of hydroxyzine in generalized anxiety disorder. Acta Psychiatr Scand Suppl 393 (1998) 102-108
12. Keller A.P. An oscillographic study of an objective tinnitus. Laryngoscope 84 (1974) 998-1003
13. Zhang J.S., Kaltenbach J.A., Wang J., and Kim S.A. Fos-like immunoreactivity in auditory and nonauditory brain structures of hamsters previously exposed to intense sound. Exp Brain Res 153 (2003) 655-660
14. Vademecum International. Medimedia-Medicom, S.A. Madrid; 2005. ISBN: 84-89327-17-3.
15. Erlandsson S., Ringdahl A., Hutchins T., and Carlsson S.G. Treatment of tinnitus: a controlled comparison of masking and placebo. Br J Audiol 21 (1987) 37-44
16. Lopez-Gonzalez M.A., and Lopez-Fernandez R. Sequential sound therapy in tinnitus. Int Tinnitus J 10 (2004) 150-155
17. Lopez-Gonzalez MA, Lopez-Fernandez R. Tinnitus integral treatment. Sequential sound therapy. Barcelona, Nexus editorial; 2004. ISBN: 84-932682-7-5.
18. Lopez-Gonzalez MA, Santiago AM, Esteban-Ortega F. Sulpiride and melatonin decrease tinnitus perception modulating the auditolimbic pathway. J Otolaryngol 2006; in press.