Association between amygdala volume and anxiety level: Magnetic resonance imaging (MRI) study in autistic children

Journal of Child Neurology

Volumn 21, Issue 12, 2006, Pages 1051-1058

  Juranek, Jenifer ^a   Felipek, Pauline A ^a,b   Berenji, Gholam R ^a   Modahl, Charlotte ^a   Osann, Kathryn ^a   Spence, M Anne ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADOLESCENT; AMYGDALOID NUCLEUS; ANXIETY; ARTICLE; AUTISM; BRAIN FUNCTION; BRAIN SIZE; CHILD; CHILD BEHAVIOR CHECKLIST; CLINICAL ARTICLE; COHORT ANALYSIS; COMORBIDITY; CONTROLLED STUDY; CORRELATION COEFFICIENT; DEPRESSION; EVIDENCE BASED MEDICINE; FEMALE; HIPPOCAMPUS; HUMAN; IMAGE ANALYSIS; LEFT HEMISPHERE; LINEAR REGRESSION ANALYSIS; MALE; MULTIVARIATE ANALYSIS; NEUROBIOLOGY; NEUROIMAGING; NUCLEAR MAGNETIC RESONANCE IMAGING; PREDICTION; PRIORITY JOURNAL; RATING SCALE; RIGHT HEMISPHERE; SCORING SYSTEM; STATISTICAL SIGNIFICANCE; SYMPTOMATOLOGY; THREE DIMENSIONAL IMAGING;

ADOLESCENT; AMYGDALA; ANXIETY DISORDERS; AUTISTIC DISORDER; CHILD; CHILD, PRESCHOOL; COMORBIDITY; DEPRESSIVE DISORDER; FEMALE; FUNCTIONAL LATERALITY; HUMANS; HYPERTROPHY; MAGNETIC RESONANCE IMAGING; MALE; NEUROPSYCHOLOGICAL TESTS; PREDICTIVE VALUE OF TESTS; STATISTICS;

EID: 33846344210     PISSN: 08830738     EISSN: None     Source Type: Journal    
DOI: 10.1177/7010.2006.00237     Document Type: Article

References (27)

1. Rumsey J, Rapoport JL, Sceery W: Autistic children as adults: Psychiatric, social, and behavioral outcomes. J Am Acad Child Adolesc Psychiatry 1985;24:465-473.
2. Muris P, Steerneman P, Merckelbach H, et al: Comorbid anxiety symptoms in children with pervasive developmental disorders. J Anxiety Disord 1998;12:387-393.
3. Gillott A, Furniss F, Walter A: Anxiety in high-functioning children with autism. Autism 2001;5:277-286.
4. Juranek J, Filipek PA: Neuroimaging in the developmental disorders, in Segalowitz S, Rapin I (eds): Child Neuro-psychology, 2nd ed, vol 8, part 1. Handbook of Neuro-psychology. Amsterdam, Elsevier, 2002, 175-194.
5. Sweeten TL, Posey DJ, Shekhar A, McDougle CJ: The amygdala and related structures in the pathophysiology of autism. Pharmacol Biochem Behav 2002;71:449-455.
6. Aylward E, Minshew N, Goldstein G, et al: MRI volumes of amygdala and hippocampus in non-mentally retarded autistic adolescents and adults. Neurology 1999;53:2145-2150.
7. Howard M, Cowell P, Boucher J, et al: Convergent neuroanatomical and behavioural evidence of an amygdala hypothesis of autism. Neuroreport 2000;11:2931-2935.
8. Piven J, Bailey A, Ranson B, Arndt S: No difference in hippocampus volume detected on magnetic resonance imaging in autistic individuals. J Autism Dev Disord 1998;28:105-110. [Erratum: J Autism Dev Disord 1998;28:271.]
9. Filipek PA, Richelme C, Kennedy DN, Caviness VS: Morphometric analysis of the brain in developmental language disorders and autism, abstract. Ann Neurol 1992;32:475.
10. Haznedar M, Buchsbaum M, Wei T, et al: Limbic circuitry in patients with autism spectrum disorders studied with positron emission tomography and magnetic resonance imaging. Am J Psychiatry 2000;157:1994-2001.
11. Filipek PA, Accardo PJ, Baranek GT, et al: The screening and diagnosis of autistic spectrum disorders. J Autism Dev Disord 1999;29:437-482.
12. Filipek PA, Accardo PJ, Ashwal S, et al: Practice parameter. Screening and diagnosis of autistic spectrum disorders. Neurology 2000;55:468-479.
13. Nowell MA, Hackney DB, Muraki AS, Coleman M: Varied MR appearance of autism: Fifty-three pediatric patients having the full autistic syndrome. Magn Reson Imaging 1990;8:811-816.
14. Filipek PA: Brief report: Neuroimaging in autism: The state of the science 1995. J Autism Dev Disord 1996;26:211-215.
15. Amaral DG, Bauman MD, Mills Schumann C: The amygdala and autism: Implications from non-human primate studies. Genes Brain Behav 2003;2:295-302.
16. Achenbach T: Manual for the Child Behavior Checklist/4-18 and 1991 Profile. Burlington, VT, University Medical Education Associates, 1991.
17. Filipek PA, Richelme C, Kennedy DN, Caviness VS: The young adult human brain: An MRI-based morphometric analysis. Cereb Cortex 1994;4:344-360.
18. Caviness VS, Kennedy DN, Richelme C, et al: The human brain age 7-11 years. A volumetric analysis based upon magnetic resonance images. Cereb Cortex 1996;6:726-736.
19. Sparks BF, Friedman SD, Shaw DW, et al: Brain structural abnormalities in young children with autism spectrum disorder. Neurology 2002;59:184-192.
20. Prather MD, Lavenex P, Mauldin-Jourdain ML, et al: Increased social fear and decreased fear of objects in monkeys with neonatal amygdala lesions. Neuroscience 2001;106: 653-658.
21. Baron-Cohen S, Ring HA, Bullmore ET, et al: The amygdala theory of autism. Neurosci Biobehav Rev 2000;24:355-364.
22. Brambilla P, Hardan A, di Nemi SU, et al: Brain anatomy and development in autism Review of structural MRI studies. Brain Res Bull 2003;61:557-569.
23. Szeszko P, MacMillan S, McMeniman M, et al: Amygdala volume reductions in pediatric patients with obsessive-compulsive disorder treated with paroxetine: Preliminary findings. Neuropsychopharmacology 2004;29:826-832.
24. Hamilton M: The assessment of anxiety states by rating. Br J Med Psychol 1959;32:50-55.
25. Hamilton M: Development of a rating scale for primary depressive illness. Br J Soc Clin Psychol 1967;6:278-296.
26. MacMillan S, Szeszko P, Moore G, et al: Increased amygdala: Hippocampal volume ratios associated with severity of anxiety in pediatric major depression. J Child Adolesc Psychapharmacol 2003;13:65-73.
27. Rauch S, Shin L, Wright C: Neuroimaging studies of amygdala function in anxiety disorders. Ann N Y Acad Sci 2003;985:389-410.