From antigen processing to peptide-MHC binding

Nature Immunology

Volumn 7, Issue 12, 2006, Pages 1277-1279

  Unanue, Emil R ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGEN; HAPTEN; LYSOZYME; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2;

ANTIBODY AFFINITY; ANTIGEN BINDING; ANTIGEN PRESENTATION; ANTIGEN PRESENTING CELL; ARTICLE; BACTERIAL INFECTION; BINDING AFFINITY; HELPER CELL; HUMAN; IMMUNE RESPONSE; IMMUNOGENICITY; MACROPHAGE; MAJOR HISTOCOMPATIBILITY COMPLEX; NONHUMAN; PHAGOCYTE; PHAGOCYTOSIS; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN INTERACTION; T LYMPHOCYTE;

ALLERGY AND IMMUNOLOGY; ANIMALS; ANTIGEN PRESENTATION; ANTIGEN-PRESENTING CELLS; HISTOCOMPATIBILITY ANTIGENS CLASS II; HISTORY, 20TH CENTURY; HUMANS; PORTRAITS;

EID: 33846317050     PISSN: 15292908     EISSN: 15292916     Source Type: Journal    
DOI: 10.1038/ni1206-1277     Document Type: Article

References (21)

1. Askonas, B.A., Auzins, I. & Unanue, E.R. Role of macrophages in the immune response. Bull. Soc. Chim. Biol. (Paris) 50, 1113-1128 (1968).
2. Unanue, E.R. Perspective on antigen processing and presentation. Immunol. Rev. 185, 86-102 (2002).
3. McDevitt, H.O. & Chinitz, A. Genetic control of the antibody response: relationship between immune response and histocompatibility (H-2) type. Science 163, 1207-1208 (1969).
4. Benacerraf, B. Role of MHC gene products in immune regulation. Science 212, 1229-1231 (1981).
5. Zinkernagel, R.M. & Doherty, P.C. Activity of sensitized thymus-derived lymphocytes in lymphocytic choriomeningitis reflects immunological surveillance against altered self components. Nature 251, 230-233 (1974).
6. Rosenthal, A.S. & Shevach, E.M. Function of macrophages in antigen recognition by guinea pig T lymphocytes. I. Requirement for histocompatible macrophages and lymphocytes. J. Exp. Med. 138, 1194-1212 (1973).
7. Ziegler, K. & Unanue, E.R. Identification of a macrophage antigen-processing event required for I-region-restricted antigen presentation to T lymphocytes. J. Immunol. 127, 1869-1875 (1981).
8. Ziegler, K. & Unanue, E.R. Decrease in macrophage antigen catabolism caused by ammonia and chloroquine is associated with inhibition of antigen presentation to T cells. Proc. Natl. Acad. Sci. USA 79, 175-178 (1982).
9. Allen, P.M. Defining yourself: Tolerance development in the immune system. J. Immunol. 177, 1369-1372 (2006).
10. Katz, M.E., Maizels, R.M., Wicker, L., Miller, A. & Sercarz, E.E. Immunological focusing by the mouse major histocompatibility complex: mouse strains confronted with distantly related lysozymes confine their attention to very few epitopes. Eur. J. Med. 12, 535-540 (1982).
11. Allen, P.M. & Unanue, E.R. Differential requirements for antigen processing by macrophages for lysozyme-specific T cell hybridoma. J. Immunol. 132, 1077-1079 (1984).
12. Allen, P.M., Strydom, D.J. & Unanue, E.R. Processing of lysozyme by macrophages: Identification of the determinant recognized by two T cell hybridomas. Proc. Natl. Acad. Sci. USA 81, 2489-2493 (1984).
13. Shimonkevitz, R., Colon, M., Kappler, J.W., Marrack, P. & Grey, H.M. Antigen recognition by H-2-restricted T cells. II. A tryptic ovalbumin peptide that substitutes for processed antigen. J. Immunol. 133, 2067-2074 (1984).
14. Babbitt, B.P., Allen, P.M., Matsueda, G., Haber, E. & Unanue, E.R. Binding of immunogenic peptides to Ia histocompatibilty molecules. Nature 317, 359-361 (1985).
15. Babbitt, B.P., Matsueda, G., Haber, E., Unanue, E.R. & Allen, P.M. Antigenic competition at the level of peptide-Ia binding. Proc. Natl. Acad. Sci. USA 83, 4509-4513 (1986).
16. Allen, P.M. et al. Identification of the T-cell and Ia contact residues of a T-cell antigenic epitope. Nature 327, 713-715 (1987).
17. Buus, S. et al. Interaction between a "processed" oval-bumin peptide and Ia molecules. Proc. Natl. Acad. Sci. USA 83, 3968-3971 (1986).
18. Buus, S., Sette, A., Colon, S.M., Miles, C. & Grey, H.M. The relationship between major histocompatibility complex (MHC) restriction and the capacity of Ia to bind immunogenic peptides. Science 235, 1353-1358 (1987).
19. Townsend, A.R.M. et al. The epitopes of influenza nucleoprotein recognized by cytotoxic T lymphocytes can be defined with short synthetic peptides. Cell 44, 959-968 (1986).
20. Bjorkman, P.J. et al. The foreign antigen binding site and T cell recognition regions of class I histocompatibility regions. Nature 329, 512-515 (1987).
21. Bjorkman, P.J. et al. Structure of the human class I histocompatibility antigen HLA-A2. Nature 329, 506-511 (1987).