Temporal and spatial expression of Pax9 and Sonic hedgehog during development of normal mouse palates and cleft palates in TGF-β3 null embryos

Archives of Oral Biology

Volumn 52, Issue 3, 2007, Pages 260-267

  Sasaki, Yasunori ^a,c   O'Kane, Sharon ^b   Dixon, Jill ^a   Dixon, Michael J ^a   Ferguson, Mark W J ^a,b  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

^b Renovo   (United Kingdom)

^c NAGASAKI UNIVERSITY GRADUATE SCHOOL OF BIOMEDICAL SCIENCES   (Japan)

Author keywords

palate development; Pax9; Secondary cleft palate; Shh; TGF 3 null mutation

Indexed keywords

PAIRED BOX TRANSCRIPTION FACTOR; PAX9 PROTEIN, MOUSE; SHH PROTEIN, MOUSE; SONIC HEDGEHOG PROTEIN; TRANSFORMING GROWTH FACTOR BETA3; UNCLASSIFIED DRUG;

ANIMAL; ARTICLE; CLEFT PALATE; FACE; GENE EXPRESSION REGULATION; GENETICS; IN SITU HYBRIDIZATION; METABOLISM; METHODOLOGY; MOUSE; MOUSE MUTANT; PALATE; PRENATAL DEVELOPMENT; SKULL;

ANIMALS; CLEFT PALATE; FACE; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HEDGEHOG PROTEINS; IN SITU HYBRIDIZATION; MICE; MICE, MUTANT STRAINS; PAIRED BOX TRANSCRIPTION FACTORS; PALATE; SKULL; TRANSFORMING GROWTH FACTOR BETA3;

ERINACEIDAE; VERTEBRATA;

EID: 33846303588     PISSN: 00039969     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.archoralbio.2006.09.012     Document Type: Article

References (26)

1. Proetzel G., Pawlowski S.A., Wiles M.V., Yin M., Boivin G.P., Howles P.N., et al. Transforming growth factor-β3 is required for secondary palate fusion. Nat Genet 11 (1995) 409-414
2. Kaartinen V., Voncken J.W., Shuler C., Warburton D., Bu D., Heisterkamp N., et al. Abnormal lung development and cleft palate in mice lacking TGF-β3 indicates defects of epithelial-mesenchymal interaction. Nat Genet 11 (1995) 415-421
3. Brunet C.L., Sharpe P.M., and Ferguson M.W.J. Inhibition of TGF-β3 (but not TGF-β1 or TGF-β2) activity prevents normal mouse embryonic palate fusion. Int J Dev Biol 39 (1995) 345-355
4. Taya Y., O'Kane S., and Ferguson M.W.J. Pathogenesis of cleft palate in TGF-β3 knockout mice. Development 126 (1999) 3869-3879
5. Barlow A.J., and Francis-west P.H. Ectopic application of recombinant BMP-2 and BMP-4 can change patterning of developing chick facial primordia. Development 124 (1997) 391-398
6. Zhang Z., Song Y., Zhao X., Zhang X., Fermin C., and Chen Y. Rescue of cleft palate in Msx1-deficient mice by transgenic Bmp4 reveals a network of BMP and Shh signaling in the regulation of mammalian palatogenesis. Development 129 (2002) 4135-4146
7. Dudas M., Nagy A., Laping N.J., Moustakas A., and Kaartinen V. TGF-β3-induced palatal fusion is mediated by Alk-5/Smad pathway. Dev Biol 266 (2004) 96-108
8. Cui X.-M., Shiomi N., Chen J., Saito T., Yamamoto T., Ito Y., et al. Overexpression of Smad2 in TGF-β3-null mutant mice rescues cleft palate. Dev Biol 278 (2005) 193-202
9. Wallin J., Mizutani Y., Imai K., Miyashita N., Moriwaki K., Taniguchi M., et al. A new pax gene, Pax9, maps to mouse chromosome 12. Mamm Genome 4 (1993) 354-358
10. Peters H., Neubüser A., Kratochwil K., and Balling R. Pax9-deficient mice lack pharyngeal pouch derivatives and teeth and exhibit craniofacial and limb abnormalities. Genes Dev 12 (1998) 2735-2747
11. Roessler E., Balloni E., Gaudenz K., Jay P., Berta P., Scherer S.W., et al. Mutations in the human Sonic Hedgehog gene cause holoprosencephaly. Nat Genet 14 (1996) 357-360
12. Bitgood M.J., and McMahon A.P. Hedgehog and Bmp genes are coexpressed at many diverse sites of cell-cell interaction in the mouse embryo. Dev Biol 172 (1995) 126-138
13. Ferguson M.W.J., and Honig L.S. Epithelial mesenchymal interactions during vertebrate palatogenesis. Curr Top Dev Biol 19 (1984) 137-164
14. Neubüser A., Koseki H., and Balling R. Characterisation and developmental expression of Pax9, a paired-box-containing gene related to Pax1. Dev Biol 170 (1995) 701-716
15. Conlon R.A., and Rossant J. Exogenous retinoic acid rapidly induces ectopic expression of murine Hox-2 gene in vitro. Development 116 (1992) 357-368
16. Wilkinson D.G. Whole mount in situ hybridization of vertebrate embryos. In: Wilkinson D.G. (Ed). In situ hybridization (1992), Oxford University Press, Oxford 75-83
17. Breitschopf H., Suchanek G., Gould R.M., Colman D.R., and Lassmann H. In situ hybridization with digoxigenin-labeled probes, Sensitive and reliable detection method applied to myelinating rat brain. Acta Neuropathol 84 (1992) 581-587
18. Sakamoto M.K., Nakamura K., Handa J., Kihara T., and Tanimura T. Morphogenesis of the secondary palate in mouse embryos with special reference to the development of rugae. Anat Rec 223 (1989) 299-310
19. Neubüser A., Peters H., Balling R., and Martin G.R. Antagonistic interactions between FGF and BMP signaling pathways: mechanism for positioning the sites of tooth formation. Cell 90 (1997) 247-255
20. Hamachi T., Sasaki Y., Hidaka K., and Nakata M. Association between palatal morphogenesis and Pax9 expression pattern in CL/Fr embryos with clefting during palatal development. Arch Oral Biol 48 (2003) 581-587
21. Pelton R.W., Hogan B.L.M., Miller D.A., and Moses H.L. Differential expression of genes encoding TGFs β1, β2, and β3 during murine palate formation. Dev Biol 141 (1990) 456-460
22. Fitzpatrick D.R., Denhez F., Kondaiah P., and Akhurst R.J. Differential expression of TGF beta isoforms in murine palatogeneisis. Development 109 (1990) 585-595
23. Wall N.A., and Hogan B.L.M. Expression of bone morphogenetic protein-4 (BMP-4), bone morphogenetic protein-7 (BMP-7), fibroblast growth factor-8 (FGF-8) and sonic hedgehog (SHH) during branchial arch development in the chick. Mech Dev 53 (1995) 383-392
24. Helms J.A., Kim C.H., Hu D., Minkoff R., Thaller C., and Eichele G. Sonic hedgehog participates in craniofacial morphogenesis and is down-regulated by teratogenic doses of retinoic acid. Dev Biol 187 (1997) 25-35
25. Laufer E., Nelson C.E., Johnson R.L., Morgan B.A., and Tabin C. Sonic hedgehog and Fgf-4 act through a signaling cascade and feedback loop to integrate growth and patterning of developing limb bud. Cell 79 (1994) 993-1003
26. Hu D., and Helms J.A. The role of Sonic hedgehog in normal and abnormal craniofacial morphogenesis. Development 126 (1999) 4873-4884