Human DNA polymerase α uses a combination of positive and negative selectivity to polymerize purine dNTPs with high fidelity

Biochemistry

Volumn 46, Issue 2, 2007, Pages 448-460

  Beckman, Jeff ^a   Kincaid, Kristi ^a   Hocek, Michal ^b   Spratt, Thomas ^c   Engels, Joachim ^d   Cosstick, Richard ^e   Kuchta, Robert D ^a  

^a UNIVERSITY OF COLORADO   (United States)

^b INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY   (Czech Republic)

^c PENN STATE COLLEGE OF MEDICINE   (United States)

^d GOETHE UNIVERSITY   (Germany)

^e UNIVERSITY OF LIVERPOOL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AMINES; DNA; MONITORING; POLYMERIZATION;

DNA POLYMERASES; NUCLEOTIDES; PURINE DNTPS; TEMPLATE BASE;

ENZYMES;

ADENINE; AMINE; BENZIMIDAZOLE; CYTOSINE; DNA DIRECTED DNA POLYMERASE ALPHA; GUANINE; NUCLEOSIDE TRIPHOSPHATE; PURINE DERIVATIVE;

3' UNTRANSLATED REGION; ARTICLE; BASE PAIRING; DNA REPLICATION; DNA TEMPLATE; ENZYME SPECIFICITY; MOLECULAR RECOGNITION; NONHUMAN; POLYMERIZATION; PRIORITY JOURNAL;

AMINO ACID SEQUENCE; BASE SEQUENCE; CATALYTIC DOMAIN; DNA; DNA POLYMERASE I; DNA REPLICATION; HUMANS; HYDROPHOBICITY; KINETICS; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PURINE NUCLEOTIDES; RECOMBINANT PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; SUBSTRATE SPECIFICITY;

EID: 33846300306     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi061243s     Document Type: Article

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