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Volumn 4, Issue 2, 2007, Pages 87-91

Symmetrical derivatives of C2-substituted pyrrolo[2,3-f]quinolines: Synthesis, cytotoxicity and drug delivery studies

(9) Tsotinis, Andrew b Vlachou, Marilena b Gerasimopoulou, Maria b Eikosipentaki, Aphrodite b Ioannidis, Constantine b Klouvidaki, Anna b Afroudakis, Pandelis A b Moreau, Dimitri a Roussakis, Christos a

a UNIVERSITÉ DE NANTES (France)

b UNIVERSITY OF ATHENS (Greece)

Author keywords

Cytotoxicity; Drug delivery; Symmetrical pyrrolo 2,3 f quinolines; Synthesis

Indexed keywords

N2 [2 [[2 [(1H PYRROLO[2,3 F] QUINOLINE 2 CARBONYLAMINO)]ETHYLAMINO]ETHYL]] 1H PYRROLO[2,3 F]QUINOLINE 2 CARBOXAMIDE; N2 [3 [[3 [(1H PYRROLO[2,3 F] QUINOLINE 2 CARBONYLAMINO)]PROPYLAMINO]PROPYL]] 1H PYRROLO[2,3 F]QUINOLINE 2 CARBOXAMIDE; N2 [3 [[4 [(1H PYRROLO[2,3 F] QUINOLINE 2 CARBONYLAMINO)]BUTYLAMINO]PROPYL]] 1H PYRROLO[2,3 F]QUINOLINE 2 CARBOXAMIDE; N2 [4 [(1H PYRROLO[2,3 F]QUINOLINE 2 CARBONYLAMINO)CYCLOHEXYL]] 1H PYRROLO[2,3 F]QUINOLINE 2 CARBOXAMIDE; N2 [5 [(1H PYRROLO[2,3 F]QUINOLINE 2 CARBONYLAMINO)PENTYL]] 1H PYRROLO[2,3 F]QUINOLINE 2 CARBOXAMIDE; N2 [6 [(1H PYRROLO[2,3 F]QUINOLINE 2 CARBONYLAMINO)]HEXYL] 1H PYRROLO[2,3 F]QUINOLINE 2 CARBOXAMIDE; N2 [[3 [4 [3 [(1H PYRROLO[2,3 F] QUINOLINE 2 CARBONYLAMINO)]PROPYLAMINO]BUTYLAMINO]PROPYL]] 1H PYRROLO[2,3 F]QUINOLINE 2 CARBOXAMIDE; PYRROLO[2,3 F]QUINOLINE DERIVATIVE; QUINOLINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CANCER CELL CULTURE; CONTROLLED STUDY; CYTOTOXICITY; DRUG DELIVERY SYSTEM; DRUG SOLUBILITY; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; LUNG NON SMALL CELL CANCER; PRIORITY JOURNAL; STOMACH JUICE;

EID: 33846293929 PISSN: 15701808 EISSN: None Source Type: Journal
DOI: 10.2174/157018007779422488 Document Type: Article

Times cited : (4)

References (9)

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7
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- Satisfactory analytical data/NMR spectra were obtained for all new compounds; this set of data is available free of charge as supplementary material upon request. Typical experimental procedure: Synthesis of N2-{3, 3, 1H-pyrrolo[2,3-f] quinoline-2-carbonylamino]methylamino}propyl, 1H-pyrrolo [2,3-f]quinoline-2-carboxamide (5a, 1,1′- Carbonyldiimidazole (CDI, 0.3 g, 2.1 mmol) was added to a stirred suspension of 1H-pyrrolo[ 2,3-f]quinoline-2-carboxylic acid (4, 0.4 g, 1.9 mmol) in DMF (5.0 ml) at room temperature. The mixture was stirred at this temperature for 3 h prior to being treated with a solution of 3,3′-diamino-N-methyldipropylamine (0.13 g, 0.9 mmol) in DMF (4.0 ml, Stirring was continued for 2 h and the solvent was evaporated in vacuo. The residue was triturated with ethyl acetate (1 ml) to give the desired compound as an off-white solid
- 2 (%): C, 69.76; H, 5.86; N, 18.38; found (%) C, 69.53; H, 5.79; N, 18.27.

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