Acetazolamide improves cerebral oxygenation during exercise at high altitude

High Altitude Medicine and Biology

Volumn 7, Issue 4, 2006, Pages 290-301

  Vuyk, Jaap ^a,b   Van Den Bos, Jan ^b   Terhell, Kees ^b   De Bos, Rene ^b   Vletter, Ad ^a   Valk, Pierre ^c   Van Beuzekom, Martie ^a   Van Kleef, Jack ^a   Dahan, Albert ^a  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^b 2005 Cho Oyu Expedition ^*  (Netherlands)

^c TNO   (Netherlands)

Author keywords

Acclimatization; Acute mountain sickness; BIS; Lake Louise score; Near infrared spectroscopy (NIRS); Psychomotor function; rSO2

Indexed keywords

ACETAZOLAMIDE;

ADULT; ALTITUDE ACCLIMATIZATION; ALTITUDE DISEASE; ARTICLE; BRAIN BLOOD FLOW; BRAIN HYPOXIA; BRAIN OXYGEN CONSUMPTION; BRAIN OXYGEN TENSION; CHINA; CLINICAL ARTICLE; CONTROLLED STUDY; DRUG EFFICACY; EXERCISE; HEART RATE; HUMAN; MOUNTAINEERING; NEAR INFRARED SPECTROSCOPY; OXYGEN SATURATION; PRIORITY JOURNAL; PSYCHOMOTOR ACTIVITY; PSYCHOMOTOR PERFORMANCE;

ACETAZOLAMIDE; ACUTE DISEASE; ADULT; ALTITUDE SICKNESS; ANALYSIS OF VARIANCE; BRAIN; CARBONIC ANHYDRASE INHIBITORS; CEREBROVASCULAR CIRCULATION; EXERCISE; FEMALE; HUMANS; MALE; MOTOR ACTIVITY; OXYGEN CONSUMPTION; REFERENCE VALUES;

EID: 33846248252     PISSN: 15270297     EISSN: None     Source Type: Journal    
DOI: 10.1089/ham.2006.7.290     Document Type: Article

References (24)

1. Bradwell A.R., Coote J.H., Milles J.J., Dykes P.W., Forster P.J.E., Chesner I., and Richardson N.V. (1986). Effect of acetazolamide on exercise performance and muscle mass at high-altitude. Lancet 1(8488):1001-1005.
2. Carrion E., Hertzog J.H., Medlock M.D., Hauser G.J., and Dalton H.J. (2001). Use of acetazolamide to decrease cerebrospinal fluid production in chronically ventilated patients with ventriculopleural shunts. Arch. Dis. Child. 84:68-71.
3. Daubeney P.E.F., Pilkington S.N., Janke E., Charlton G.A., Smith D.C., and Webber S.A. (1996). Cerebral oxygenation measured by near-infrared spectroscopy: comparison with jugular bulb oximetry. Ann. Thorac. Surg. 61:930-934.
4. DeLorey D.S., Kowalchuk J.M., and Paterson D.H. (2003). Relationship between pulmonary O-2 uptake kinetics and muscle deoxygenation during moderate-intensity exercise. J. Appl. Physiol. 95:113-120.
5. Dumont L., Mardirosoff C., and Tramer M.R. (2000). Efficacy and harm of pharmacological prevention of acute mountain sickness: quantitative systematic review. BMJ 321:267-272.
6. Gertsch J.H., Basnyat B., Johnson E.W., Onopa J., and Holck P.S. (2004). Randomised, controlled trial of Ginkgo Biloba and acetazolamide for prevention of acute mountain sickness: the prevention of high altitude illness trial (PHAIT). BMJ 328:797-799.
7. Hackett P.H., and Roach R.C. (2001). Current concepts: High-altitude illness. New Engl. J. Med. 345:107-114.
8. Hackett P.H., and Roach R.C. (2004). High altitude cerebral edema. High Alt. Med. Biol. 5:136-146.
9. Huang S.Y., McCullough R.E., Mccullough R.G., Micco A.J., Mancojohnson M., Weil J.V., and Reeves J.T. (1988). Usual clinical dose of acetazolamide does not alter cerebral blood-flow velocity. Resp. Physiol. 72:315-326.
10. Imray C.H.E., Myers S.D., Pattinson K.T.S., Bradwell A.R., Chan C.W., Harris S., Collins P., and Wright A.D. (2005). Effect of exercise on cerebral perfusion in humans at high altitude. J. Appl. Physiol. 99:699-706.
11. Kim M.B., Ward D.S., Cartwright C.R., Kolano J., Chlebowski S., and Henson L.C. (2000). Estimation of jugular venous O-2 saturation from cerebral oximetry or arterial O-2 saturation during isocapnic hypoxia. J. Clin. Monitoring Computing 16:191-199.
12. Lezak M.D. (1984). Neuropsychological assessment in behavioral toxicology - developing techniques and interpretative issues. Scand. J. Work Environ. Health 10:25-29.
13. Liu G.T., Volpe N.J., and Galetta S.L. (1998). Pseudotumor cerebri and its medical treatment. Drugs Today 34:563-574.
14. Mukherjee B., Preece M., Houston G.C., Papadakis N.G., Carpenter T.A., Hall L.D., and Huang C.L.H. (2005). Mapping of the cerebral response to acetazolamide using graded asymmetric spin echo EPI. Magn. Reson. Imaging 23:907-920.
15. Obrig H., and Villringer A. (2003). Beyond the visible - imaging the human brain with light. J. Cereb. Blood Flow Metab. 23:1-18.
16. Obrig H., Wenzel R., Kohl M., Horst S., Wobst P., Steinbrink J., Thomas F., and Villringer A. (2000). Near-infrared spectroscopy: does it function in functional activation studies of the adult brain? Int. J. Psychophysiol. 35:125-142.
17. Ohmae E., Ouchi Y., Oda M., Suzuki T., Nobesawa S., Kanno T., Yoshikawa E., Futatsubashi M., Ueda Y., Okada H., and Yamashita Y. (2006). Cerebral hemodynamics evaluation by near-infrared time-resolved spectroscopy: correlation with simultaneous positron emission tomography measurements. Neuroimage 29:697-705.
18. Valk P.J., Simons R.M., Struyvenberg P.A., Kruit H., and Henegouwen M.T.V.B. (1997). Effects of a single dose of loratadine on flying ability under conditions of simulated cabin pressure. Am. J. Rhinol. 11:27-33.
19. Villringer A., and Chance B. (1997). Non-invasive optical spectroscopy and imaging of human brain function. Trends Neurosci. 20:435-442.
20. Virtués-Ortega J., Buela-Casal G., Garrido E., and Alcazar B. (2004). Neuropsychological functioning associated with high-altitude exposure. Neuropsychol. Rev. 14:197-224.
21. Vogh B.P., and Doyle A.S. (1981). The effect of carbonicanhydrase inhibitors and other drugs on sodium entry to cerebrospinal fluid. J. Pharmacol. Exper. Therap. 217:51-56.
22. Vuyk J., Lichtenbelt B.J., Vieveen J., Dahan A., Engbers F.H.M., and Burm A.G.L. (2004). Low bispectral index values in awake volunteers receiving a combination of propofol and midazolam. Anesthesiology 100:179-181.
23. Vuyk J., and Mertens M. (2003). Bispectral index scale (BIS) monitoring and intravenous anaesthesia. Adv. Modelling Clin. Application Intravenous Anaesth. 523:95-104.
24. West J.B. (2004). The physiologic basis of high-altitude diseases. Ann. Intern. Med. 141:789-800.