Exercise capacity of cardiac asymptomatic hereditary hemochromatosis subjects

Medicine and Science in Sports and Exercise

Volumn 39, Issue 1, 2007, Pages 3-7

  Shizukuda, Yukitaka ^a   Bolan, Charles D ^b   Tripodi, Dorothy J ^a   Yau, Yu Ying ^b   Smith, Kevin P ^a   Arena, Ross ^c   Waclawiw, Myron A ^a   Leitman, Susan F ^b   Rosing, Douglas R ^a  

^a NATIONAL HEART LUNG AND BLOOD INSTITUTE   (United States)

^b NATIONAL INSTITUTES OF HEALTH   (United States)

^c VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

Author keywords

Exercise capacity; Hereditary hemochromatosis; Metabolism; Symptom limited exercise

Indexed keywords

CARBON DIOXIDE; IRON;

ADULT; ANALYZER; ARTICLE; CASE CONTROL STUDY; CLINICAL ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; DISEASE ASSOCIATION; ECG ABNORMALITY; EXERCISE; EXERCISE TEST; FEMALE; GAS ANALYSIS; HEART ARRHYTHMIA; HEMOCHROMATOSIS; HUMAN; IRON DEPLETION; IRON OVERLOAD; LUNG MINUTE VOLUME; MALE; METABOLIC STRESS; OXYGEN CONSUMPTION; PHLEBOTOMY; STATISTICAL ANALYSIS;

ADULT; EXERCISE; FEMALE; HEMOCHROMATOSIS; HUMANS; IRON; MALE; MIDDLE AGED; OXYGEN CONSUMPTION; UNITED STATES;

EID: 33846242474     PISSN: 01959131     EISSN: 15300315     Source Type: Journal    
DOI: 10.1249/01.mss.0000240323.08406.f3     Document Type: Article

References (24)

1. ADAMS, P. C., D. M. REBOUSSIN, J. C. BARTON, et al. Hemochromatosis and iron-overload screening in a racially diverse population. N. Engl. J. Med. 352:1769-1778, 2005.
2. 2 slope in patients with heart failure: a prognostic comparison. Am. Heart J. 147:354-360, 2004.
3. BEAVER, W. L., K. WASSERMAN, and B. J. WHIPP. A new method for detecting anaerobic threshold by gas exchange. J. Appl. Physiol. 60:2020-2027, 1986.
4. BRUCE, R. A. Methods of exercise testing. Step test, bicycle, treadmill, isometrics. Am. J. Cardiol. 33:715-720, 1974.
5. CHICHARRO, J. L., J. HOYOS, F. GOMEZ- GALLEGO, et al. Mutations in the hereditary haemochromatosis gene HFE in professional endurance athletes. Br. J. Sports Med. 38:418-421, 2004.
6. CHUA, T. P., P. PONIKOWSKI, D. HARRINGTON, et al. Clinical correlates and prognostic significance of the ventilatory response to exercise in chronic heart failure. J. Am. Coll. Cardiol. 29:1585-1590, 1997.
7. DABESTANI, A., J. S. CHILD, J. K. PERLOFF, W. G. FIGUEROA, H. R. SCHELBERT, and T. R. ENGEL. Cardiac abnormalities in primary hemochromatosis. Ann. N. Y. Acad. Sci. 526:234-244, 1988.
8. DAVIS, J. A., K. M. SORRENTINO, E. M. NINNESS, P. H. PHAM, S. DORADO, and K. B. COSTELLO. Test-retest reliability for two indices of ventilatory efficiency measured during cardiopulmonary exercise testing in healthy men and women. Clin. Physiol. Funct. Imaging 26:191-196, 2006.
9. FEDER, J. N., A. GNIRKE, W. THOMAS, et al. A novel MHC class I-like gene is mutated in patients with hereditary haemochromatosis. Nat. Genet. 13:399-408, 1996.
10. GORAYA, T. Y., S. J. JACOBSEN, P. A. PELLIKKA, et al. Prognostic value of treadmill exercise testing in elderly persons. Ann. Intern. Med. 132:862-870, 2000.
11. HABEDANK, D., I. REINDL, G. VIETZKE, et al. Ventilatory efficiency and exercise tolerance in 101 healthy volunteers. Eur. J. Appl. Physiol. Occup. Physiol. 77:421-426, 1998.
12. ISSEKUTZ, B. JR., and K. RODAHL. Respiratory quotient during exercise. J. Appl. Physiol. 16:606-610, 1961.
13. JONES, N. L., L. MARKRIDES, C. HITCHCOCK, T. CHYPCHAR, and N. MCCARTNEY. Normal standars for an incremental progressive cycle ergometer test. Am. Rev. Respir. Dis. 129(Suppl.):S49-S55, 1985.
14. KLEBER, F. X., G. VIETZKE, K. D. WERNECKE, et al. Impairment of ventilatory efficiency in heart failure: prognostic impact. Circulation 101:2803-2809, 2000.
15. LEITMAN, S. F., J. N. BROWNING, Y.-Y. YAU, et al. Hemochromatosis subjects as allogeneic blood donors: a prospective study. Transfusion 43:1538-1544, 2003.
16. OLSON, L. J., W. P. BALDUS, and A. J. TAJIK. Echocardiographic features of idiopathic hemochromatosis. Am. J. Cardiol. 60:885-889, 1987.
17. PALKA, P., G. MACDONALD, A. LANGE, and D. J. BURSTOW. The role of Doppler left ventricular filling indexes and Doppler tissue echocardiography in the assessment of cardiac involvement in hereditary hemochromatosis. J. Am. Soc. Echocardiogr. 15:884-890, 2002.
18. PHATAK, P. D., R. L. SHAM, R. F. RAUBERTAS, et al. Prevalence of hereditary hemochromatosis in 16031 primary care patients. Ann. Intern. Med. 129:954-961, 1998.
19. SHAM, R. L., R. F. RAUBERTAS, C. BRAGGINS, J. CAPPUCCIO, M. GALLAGHER, and P. D. PHATAK. Asymptomatic hemochromatosis subjects: genotypic and phenotypic profiles. Blood 96:3707-3711, 2000.
20. SHIZUKUDA, Y., C. D. BOLAN, D. J. TRIPODI, et al. Left ventricular systolic function during stress echocardigraphy exercise in subjects with asymptomatic hereditary hemochromatosis. Am. J. Cardiol. 98:694-698, 2006.
21. SIMONTON, C. A., M. B. HIGGINBOTHAM, and F. R. COBB. The ventilatory threshold: quantitative analysis of reproducibility and relation to arterial lactate concentration in normal subjects and in patients with chronic congestive heart failure. Am. J. Cardiol. 62:100-107, 1988.
22. WEBER, K. T., J. S. JANICKI, and P. A. MCELROY. Determination of aerobic capacity and the severity of chronic cardiac and circulatory failure. Circulation 76:VI40-VI45, 1987.
23. WITTE, D. L., W. H. CROSBY, C. Q. EDWARDS, V. F. FAIRBANKS, and F. A. MITROS. Practice guideline development task force of the College of American Pathologists. Hereditary hemochromatosis. Clin. Chim. Acta 245:139-200, 1996.
24. World Medical Association declaration of Helsinki. Recommendations guiding physicians in biomedical research involving human subjects. JAMA 277:925-926, 1997.