Human keratinocyte Toll-like receptors promote distinct immune responses

Journal of Investigative Dermatology

Volumn 127, Issue 2, 2007, Pages 262-263

  Miller, Lloyd S ^a   Modlin, Robert L ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTERFERON; BACTERIAL DNA; BETA INTERFERON; CHEMOKINE; CYTOKINE; FLAGELLIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 8; LIPOPEPTIDE; LIPOPOLYSACCHARIDE; MACROPHAGE INFLAMMATORY PROTEIN 3ALPHA; MONOCYTE CHEMOTACTIC PROTEIN 1; TOLL LIKE RECEPTOR; TOLL LIKE RECEPTOR 1; TOLL LIKE RECEPTOR 10; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 3; TOLL LIKE RECEPTOR 4; TOLL LIKE RECEPTOR 5; TOLL LIKE RECEPTOR 6; TOLL LIKE RECEPTOR 9; TUMOR NECROSIS FACTOR ALPHA;

ANTIVIRAL ACTIVITY; CELL ACTIVATION; CELL SURFACE; CYTOKINE PRODUCTION; HELPER CELL; HOST RESISTANCE; HUMAN; IMMUNE RESPONSE; INNATE IMMUNITY; KERATINIZATION; KERATINOCYTE; MEMORY T LYMPHOCYTE; NEUTROPHIL CHEMOTAXIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVIEW;

EID: 33846241303     PISSN: 0022202X     EISSN: 15231747     Source Type: Journal    
DOI: 10.1038/sj.jid.5700559     Document Type: Note

References (11)

1. Baker BS, Ovigne JM, Powles AV, Corcoran S, Fry L (2003) Normal keratinocytes express Toll-like receptors (TLRs) 1, 2 and 5: modulation of TLR expression in chronic plaque psoriasis. Br J Dermatol 148:670-9
2. Dai X, Sayama K, Yamasaki K, Tohyama M, Shirakata Y, Hanakawa Y et al. (2006) SOCS1-negative feedback of STAT1 activation is a key pathway in the dsRNA-induced innate immune response of human keratinocytes. J Invest Dermatol 126:1574-81
3. Iwasaki A, Medzhitov R (2004) Toll-like receptor control of the adaptive immune responses. Nat Immunol 5:987-95
4. Kaisho T, Akira S (2006) Toll-like receptor function and signaling. J Allergy Clin Immunol 117:979-87
5. Kawai K, Shimura H, Minagawa M, Ito A, Tomiyama K, Ito M (2002) Expression of functional Toll-like receptor 2 on human epidermal keratinocytes. J Dermatol Sci 30:185-94
6. Kollisch G, Kalali BN, Voelcker V, Wallich R, Behrendt H, Ring J et al. (2005) Various members of the Toll-like receptor family contribute to the innate immune response of human epidermal keratinocytes. Immunology 114:531-41
7. Lebre MC, van der Aar AMG, van Baarsen L, van Capel TMM, Schuitemaker JHN, Kapsenberg ML et al. (2007) Human keratinocytes express functional Toll-like receptor 3, 4, 5, and 9. J Invest Dermatol 127:331-341.
8. Mempel M, Voelcker V, Kollisch G, Plank C, Rad R, Gerhard M et al. (2003) Toll-like receptor expression in human keratinocytes: nuclear factor kappaB controlled gene activation by Staphylococcus aureus is toll-like receptor 2 but not toll-like receptor 4 or platelet activating factor receptor dependent. J Invest Dermatol 121:1389-96
9. Miller LS, Sorensen OE, Liu PT, Jalian HR, Eshtiaghpour D, Behmanesh BE et al. (2005) TGF-alpha regulates TLR expression and function on epidermal keratinocytes. J Immunol 174:6137-43
10. Pivarcsi A, Bodai L, Rethi B, Kenderessy-Szabo A, Koreck A, Szell M et al. (2003) Expression and function of Toll-like receptors 2 and 4 in human keratinocytes. Int Immunol 15:721-30
11. Song PI, Park YM, Abraham T, Harten B, Zivony A, Neparidze N et al. (2002) Human keratinocytes express functional CD14 and toll-like receptor 4. J Invest Dermatol 119:424-32