Pharmacokinetic interaction between valproic acid and imipenem [3];Descripción de un caso de interacción farmacocinética entre ácido valproico e imipenem

Farmacia Hospitalaria

Volumn 30, Issue 5, 2006, Pages 316-317

  Perea Falomir, M ^a   Roura Pochs, S ^a   Higueruelo Demason S ^a   Garcia Gil V J ^a  

^a HOSPITAL GENERAL DE VIC   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

CARBAPENEM; GABAPENTIN; IMIPENEM; METRONIDAZOLE; VALPROIC ACID; VANCOMYCIN;

DRUG BLOOD LEVEL; DRUG EFFECT; EPILEPSY; GRAND MAL EPILEPSY; HUMAN; LETTER; LIVER CIRRHOSIS; NEUROTOXICITY; RASH;

EID: 33846232574     PISSN: 11306343     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1130-6343(06)73998-8     Document Type: Letter

References (6)

1. De Turck BJG, Diltoer MW, Cornelis PJWW, Maes V, Spapen HDM, Camu F, et al. Lowering of plasma valproic acid concentrations during concomitant therapy with meropenem and amikacin. J Antimicrob Chemother 1998; 42: 563-4.
2. Nacarkucuk E, Saglam H, Okan M. Meropenem decreases serum level of valproic acid. Pediatr Neurol 2004; 31: 232-4.
3. Coves FJ, Borrás J, Navarro A, Murcia A, Palacios F. Acute seizure due to a probable interaction between valproic acid and meropenem. Ann Pharmacother 2005; 39: 533-7.
4. Llinares F, Bosacoma N, Hernández C, Climent E, Selva J, Ordovás JP. Interacción farmacocinética entre ácido valproico y antibióticos carbapenémicos: descripción de tres casos. Farm Hosp 2003; 27: 258-63.
5. Yokogawa K, Iwashita S, Kubota A, Sasaki Y, Ishizaki J, Kawahara M, et al. Effect of meropenem on disposition: kinetics of valproate and its metabolites in rabbits. Pharm Res 2001; 18: 1320-6.
6. Sala F, Padullés N, Hidalgo E, Clemente S, Cabañas MJ, Oliveras M, et al. Interacción farmacocinética entre ácido valproico y meropenem. An Pediatr (Barc) 2006; 64: 93-5.