Synthesis and biological activation of an ethylene glycol-linked amino acid conjugate of cyclic cidofovir

Bioorganic and Medicinal Chemistry Letters

Volumn 17, Issue 3, 2007, Pages 583-586

  Eriksson, Ulrika ^a,b   Hilfinger, John M ^c   Kim, Jae Seung ^c   Mitchell, Stefanie ^c   Kijek, Paul ^c   Borysko, Katherine Z ^b   Breitenbach, Julie M ^b   Drach, John C ^b   Kashemirov, Boris A ^a   McKenna, Charles E ^a  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^b UNIVERSITY OF MICHIGAN   (United States)

^c TSRL INC   (United States)

Author keywords

Anti viral; Biodefense; Biotransformation; cHPMPC; HCMV; HPMPC; Prodrug

Indexed keywords

AMINO ACID DERIVATIVE; CIDOFOVIR; ETHYLENE DERIVATIVE;

AMINO ACID ANALYSIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG DOSAGE FORM COMPARISON; DRUG SYNTHESIS; DRUG TRANSPORT; HYDROLYSIS; IC 50; NONHUMAN; PH MEASUREMENT; RAT;

AMINO ACIDS; ANIMALS; ANTIVIRAL AGENTS; BIOLOGICAL AVAILABILITY; BIOTRANSFORMATION; CELL SURVIVAL; CYTOSINE; ETHYLENE GLYCOL; HALF-LIFE; HUMANS; HYDROLYSIS; KB CELLS; MAGNETIC RESONANCE SPECTROSCOPY; PHENYLALANINE; PHOSPHONIC ACIDS; PLAQUE ASSAY; PRODRUGS; RATS; SYMPORTERS; VALINE;

RATTUS;

EID: 33846231482     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2006.11.012     Document Type: Article

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