A simulated weightlessness state diminishes cortical bone healing responses

Journal of Musculoskeletal Neuronal Interactions

Volumn 6, Issue 4, 2006, Pages 327-328

  Midura, Ronald J ^a   Su, X ^a   Androjna, C ^a  

^a LERNER RESEARCH INSTITUTE   (United States)

Author keywords

Bone healing; In vivo micro CT imaging; Osteoprogenitor colony forming units; Weightlessness

Indexed keywords

ALKALINE PHOSPHATASE;

ARTICLE; BED REST; BONE DEVELOPMENT; BONE INJURY; BONE REGENERATION; BONE STRENGTH; COLONY FORMING UNIT; COMPUTER ASSISTED TOMOGRAPHY; CONNECTIVE TISSUE; CORTICAL BONE; ENZYME ACTIVITY; EXTRACELLULAR MATRIX; FATALITY; FRACTURE; FRACTURE HEALING; HISTOPATHOLOGY; HUMAN; IMMOBILIZATION; INCIDENCE; NONHUMAN; OSTEOTOMY; PARALYSIS; QUALITY OF LIFE; SPACE FLIGHT; STEM CELL; WEIGHT BEARING; WEIGHTLESSNESS;

ANIMALS; BONE REGENERATION; BONY CALLUS; FRACTURE HEALING; FRACTURES, BONE; MODELS, ANIMAL; OSTEOGENESIS; RATS; WEIGHT-BEARING; WEIGHTLESSNESS SIMULATION;

EID: 33846230467     PISSN: 11087161     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (6)

1. Sweeney JR, Marshall GJ, Gruber HE, Kirchen ME. Effects of non-weight bearing on fracture healing. Physiologist 1984; 27(Suppl.):S35-S36.
2. Sweeney JR, Gruber HE, Kirchen ME, Marshall GJ. Effects of non-weight bearing on callus formation. Physiologist 1985; 28(Suppl.6):S63-64.
3. Kaplansky AS, Durnova GN, Burkovskaya TE, Vorotnikova EV. The effect of microgravity on bone fracture healing in rats flown on COSMO-1044. Physiologist 1991; 34(Suppl.1):Sl96-199.
4. Kirchen ME, O'Connor KM, Gruber HE, Sweeney JR, Fras IA, Stover SJ, Sarmiento A, Marshall GJ. Effects of microgravity on bone healing in a rat fibular osteotomy model. Clin Orthop Relat Res 1995; 318:231-242.
5. Midura RJ, Ibiwoye MO, Powell KA, Sakai Y, Doehring T, Grabiner MD, Patterson TE, Zborowski M, Wolfman A. Pulsed electromagnetic field treatments enhance the healing of fibular osteotomies. J Orthop Res 2005; 23:1035-1046.
6. Kostenuik PJ, Harris J, Halloran BP, Turner RT, Morey-Holton ER, Bikle DD. Skeletal unloading causes resistance of osteoprogenitor cells to parathyroid hormone and to insulin-like growth factor-I. J Bone Miner Res 1999; 14:21-31.