Reduced-intensity conditioning regimen using low-dose total body irradiation before allogeneic transplant for hematologic malignancies: Experience from the European Group for Blood and Marrow Transplantation

International Journal of Radiation Oncology Biology Physics

Volumn 67, Issue 2, 2007, Pages 544-551

  Belkacémi, Yazid ^a   Labopin, Myriam ^b   Hennequin, Christophe ^c   Hoffstetter, Sylvette ^d   Mungai, Raffaello ^e   Wygoda, Marc ^f   Lundell, Marie ^g   Finke, Jurgen ^h   Aktinson, Chris ⁱ   Lorchel, Frédéric ^j   Durdux, Catherine ^k   Basara, Nadezda ^l  

^a CENTRE OSCAR LAMBRET   (France)

^b European Group for Blood   (France)

^c SAINT LOUIS HOSPITAL   (France)

^d CENTRE ALEXIS VAUTRIN   (France)

^e AZ Ospedaleria   (Italy)

^f HADASSAH HEBREW UNIVERSITY MEDICAL CENTER   (Israel)

^g KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^h Klinic Strahlentherapie   (Germany)

ⁱ CHRISTCHURCH HOSPITAL   (New Zealand)

^j UNIVERSITY HOSPITAL OF BESANÇON   (France)

^k HÔPITAL EUROPÉEN GEORGES POMPIDOU   (France)

^l Department of Bone Marrow Transplantation and Hematology/Oncology   (Germany)

more..

Author keywords

Allogeneic; Nonmyeloablative conditioning; Reduced intensity regimen; Total body irradiation; Transplantation

Indexed keywords

CELLS; GROWTH KINETICS; PATIENT TREATMENT; TRANSPLANTATION (SURGICAL); TUMORS;

ALLOGENEIC TRANSPLANTATION; NONMYELOABLATIVE CONDITIONING; REDUCED INTENSITY REGIMEN; TOTAL BODY IRRADIATION;

ONCOLOGY;

CYCLOSPORIN; FLUDARABINE; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER;

ACUTE GRAFT VERSUS HOST DISEASE; ADULT; AGED; ALLOGENIC BONE MARROW TRANSPLANTATION; ARTICLE; BLOOD DONOR; BLOOD TRANSFUSION; CONTROLLED STUDY; ENGRAFTMENT SYNDROME; FEMALE; FOLLOW UP; HEMATOLOGIC MALIGNANCY; HLA SYSTEM; HUMAN; IMMUNOCOMPETENT CELL; LEUKEMIA; LOW ENERGY RADIATION; LYMPHOMA; MAJOR CLINICAL STUDY; MALE; MULTIPLE MYELOMA; MULTIVARIATE ANALYSIS; MYELODYSPLASIA; MYELOPROLIFERATIVE DISORDER; POPULATION SIZE; PRIORITY JOURNAL; PROGNOSIS; RADIATION CHIMERA; REDUCED INTENSITY CONDITIONING; REMISSION; RISK FACTOR; STATISTICAL SIGNIFICANCE; STEM CELL; WHOLE BODY RADIATION;

ADOLESCENT; ADULT; AGED; ANALYSIS OF VARIANCE; CHILD; CHILD, PRESCHOOL; FEMALE; HEMATOLOGIC NEOPLASMS; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMANS; MALE; MIDDLE AGED; RADIOTHERAPY DOSAGE; TRANSPLANTATION CONDITIONING; TRANSPLANTATION, HOMOLOGOUS; TREATMENT OUTCOME; WHOLE-BODY IRRADIATION;

EID: 33846226431     PISSN: 03603016     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijrobp.2006.08.049     Document Type: Article

References (35)

1. Thomas E.D. Bone marrow transplantation for malignant disease. J Clin Oncol 1 (1983) 517-551
2. Gale R.P., Bortin M.M., Van Bekkum D.W., et al. Risk factors for acute graft-versus-host-disease. Br J Haematol 67 (1987) 397-406
3. Childs R., Clave E., Cotentin N., et al. Engraftment kinetics after nonmyeloablative allogeneic peripheral blood stem cell transplantation: Full donor T-cell chimerism precedes alloimmune responses. Blood 94 (1999) 3234-3241
4. Slavin S., Nagler A., Naparstek E., et al. Nonmyeloablative stem cell transplantation and cell therapy as an alternative to conventional bone marrow transplantation with lethal cytoreduction for the treatment of malignant and nonmalignant hematologic disease. Blood 91 (1998) 756-763
5. Dansey R.D., and Baynes R.D. Nonablative allogeneic hematopoietic stem cell. Curr Opin Oncol 13 (2001) 27-32
6. Georges G.E., Maris M., Sandmaier B.M., et al. Related and unrelated nonmyeloablative hematopoietic stem cell transplantation for malignant disease. In J Hematol 76 (2002) 184-189
7. Giralt S., Estey E., Albitar M., et al. Engraftment of hematopoietic progenitor cells with purine analog-containing chemotherapy: Harnessing graft-versus-leukemia without myeloablative therapy. Blood 89 (1997) 4531-4536
8. Dreger P., Brand R., Hansz J., et al. Treatment-related mortality and graft-versus-leukemia activity after allogeneic stem cell transplantation for chronic lymphocytic leukemia with intensity reduced conditioning. Leukemia 17 (2003) 841-848
9. Khouri I.F., Keating M., Körbling M., et al. Transplant-lite: Induction of graft-versus-malignancy using fludarabine-based nonablative chemotherapy and allogeneic blood progenitor-cell transplantation as treatment for lymphoid malignancies. J Clin Oncol 16 (1998) 2817-2824
10. Grigg A., Seymour J.F., Roberts A., et al. Mini-allografts for hematological malignancies: An alternative to conventional myeloablative marrow transplantation. J Med 29 (1999) 308-314
11. Giralt S., Thall P.F., Khouri I., et al. Melphalan and purine analog-containing preparative regimens: Reduced-intensity conditioning for patients with hematologic malignancies undergoing allogeneic progenitor cell transplantation. Blood 97 (2001) 631-637
12. Sykes M., Preffer F., McAFee S., et al. Mixed lymphohaematopoietic chimerism and graft-versus-lymphoma effects after non-myeloablative therapy and HLA-mismatched bone-marrow transplantation. Lancet 353 (1999) 1755-1759
13. Orsini E., Alyea E.P., Chillemi A., et al. Conversion to full donor chimerism following donor lymphocyte infusion is associated with disease response in patients with multiple myeloma. Biol Blood Marrow Transplant 6 (2000) 375-386
14. Nagler A., Salvin S., Varadi G., et al. Allogeneic peripheral blood stem cell transplantation using fludarabine-based low intensity conditioning regimen for malignant lymphoma. Bone Marrow Transplant 25 (2000) 1021-1028
15. Maris M., and Storb R. The transplantation of hematopoietic stem cells after nonmyeloablative conditioning: A cellular therapeutic approach to hematologic and genetic diseases. Immunol Res 28 (2003) 13-24
16. Awedan A. The role of non-myeloablative conditioning in allowing engraftment of allogeneic hematopoietic cells for correction of genetic disorders and for immunotherapy of leukemia. Ann Transplant 6 (2001) 9-13
17. Gooley T.A., Leisenring W., Crowley J.A., et al. Estimation of failure probabilities in the presence of competing risks: New representations of old estimators. Stat Med 18 (1999) 665-706
18. Kaplan E.L., and Meier P. Nonparametric estimation from incomplete observations. J Am Stat Assoc 53 (1958) 457-481
19. Fine J.P., and Gray R.J. A proportional hazards model for subdistribution of a competing risk. J Am Stat Assoc 94 (1999) 496-509
20. Sandmaier B.M., Maloney D.G., Gooley T., et al. Nonmyeloablative hematopoietic stem cell transplants (HSCT) from HLA matched related donors for patients with hematologic malignancies: Clinical results of TBI-based conditioning regimen. [Abstract]. Blood 98 (2001) 742a-743a
21. Bertz H., Potthoff K., and Finke J. Allogeneic stem-cell transplantation from related and unrelated donor older patients with myeloid leukemia. J Clin Oncol 21 (2003) 1480-1484
22. Crawley C., Szydlo R., Lalancette M., et al. Outcomes of reduced intensity transplantation for chronic myeloid leukaemia: an analysis of prognostic factors from the chronic leukemia working party of the EBMT. Blood 106 (2005) 2969-2976
23. Dreger P., Brand R., Milligan D., et al. Reduced-intensity conditioning lowers treatment-related mortality of allogeneic stem cell transplantation for chronic lymphocytic leukemia: A population-matched analysis. Leukemia 19 (2005) 1029-1033
24. Weisdorf D., Hakke R., Blazar B., et al. Risk factors for acute graft-versus-host disease in histocompatible donor bone marrow transplantation. Transplantation 51 (1991) 1197-1203
25. Nash R., Pepe M., and Storb R. Acute graft-versus-host disease: Analysis of risk factors after allogeneic bone marrow transplantation and prophylaxis with cyclosporine and methotrexate. Blood 80 (1992) 1838-1845
26. Valcarcel D., Martino R., Sureda A., et al. Conventional versus reduced conditioning regimen for allogeneic stem cell transplantation in patients with hematologic malignancies. Blood 105 (2005) 4143-4145
27. Kim D.H., Sohn S.K., Baek J.H., et al. Retrospective multicenter study of allogeneic peripheral blood stem cell transplantation followed by reduced-intensity conditioning or conventional myeloablative regimen. Acta Haematol 113 (2005) 220-227
28. Hallemeier C. High rate of graft failure in 25 patients with chronic myelogenous leukemia conditioned with a reduced intensity regimen of 550 cGy total body irradiation and cyclophosphamide for unrelated donor transplantation. Biol Blood Marrow Transplant 10 (2004) 726-727
29. Nademanee A., Schmidt G.M., Parker P., et al. The outcome of matched unrelated donor bone marrow transplantation in patients with hematologic malignancies using molecular typing for donor selection and graft-versus-host disease prophylaxis regimen of cyclosporine, methotrexate and prednisone. Blood 92 (1998) 2288-2293
30. Schwartz J.M., Wolford J.L., Thornquist M.D., et al. Severe gastrointestinal bleeding after hematopoietic cell transplantation. 1987-1997: Incidence, causes and outcome. Am J Gastroenterol 96 (2001) 385-393
31. Mielcarek M., Martin P.J., Leisenring W., et al. Graft-versus-host disease after nonmyeloablative versus conventional hematopoietic stem cell transplantation. Blood 102 (2003) 756-762
32. Kusumi E., Kami M., Kanda Y., et al. Reduced-intensity hematopoietic stem-cell transplantation for malignant lymphoma: A retrospective survey of 112 adult patients in Japan. Bone Marrow Transplant 36 (2005) 205-213
33. Basara N., Roemer E., Kraut L., et al. Reduced intensity preparative regimens for allogeneic hematopoietic stem cell transplantation: A single center experience. Bone Marrow Transplant 30 (2002) 651-659
34. Storb R., Sale G., Barnett T., et al. Transient mixed hematopoietic chimerism in dogs given thymic irradiation before and pharmacologic immunosuppression after marrow transplantation. Blood 97 (2001) 2915-2916
35. Maris M.B., Niederwieser D., Sandmaier B.M., et al. HLA-matched unrelated donor hematopoietic cell transplantation after nonmyeloablative conditioning for patients with hematologic malignancies. Blood 102 (2003) 2021-2030