Degradation rate of lyophilized insulin, exhibiting an apparent Arrhenius behavior around glass transition temperature regardless of significant contribution of molecular mobility

Journal of Pharmaceutical Sciences

Volumn 95, Issue 12, 2006, Pages 2684-2691

  Yoshioka, Sumie ^a   Miyazaki, Tamaki ^a   Aso, Yukio ^a  

^a NATIONAL INSTITUTE OF HEALTH SCIENCES   (Japan)

Author keywords

Amorphous; Glass transition; Lyophilization; Molecular mobility; Shelf life; Solid state stability

Indexed keywords

ALPHA,BETA POLY(N HYDROXYETHYL)ASPARTAMIDE; EXCIPIENT; HUMAN INSULIN; TREHALOSE; UNCLASSIFIED DRUG;

ARTICLE; COMPARATIVE STUDY; DRUG ACTIVATION; DRUG DEGRADATION; DRUG STABILITY; FREEZE DRYING; GLASS TRANSITION TEMPERATURE; HUMIDITY; HYDROGEN BOND; MATHEMATICAL COMPUTING; MOLECULAR MECHANICS; SHELF LIFE; TEMPERATURE DEPENDENCE;

EID: 33846202570     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.20689     Document Type: Article

References (10)

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