Increasing HIV type 1 polymorphic diversity but no resistance to antiretroviral drugs in untreated patients from Central African Republic: A 2005 study

AIDS Research and Human Retroviruses

Volumn 22, Issue 10, 2006, Pages 1036-1044

  Marechal, Valerie ^a   Jauvin, Valerie ^b   Selekon, Benjamin ^a   Leal, Josianne ^a   Pelembi, Pulcherie ^a   Fikouma, Valentin ^c   Gabrie, Philippe ^d   Heredeibona, Luc Salva ^e   Goumba, Charles ^d   Serdouma, Eugène ^d   Ayouba, Ahidjo ^f   Fleury, Hervé ^b  

^a INSTITUT PASTEUR DE BANGUI   (Central African Republic)

^b University Victor Segalen   (France)

^c Hôpital de l'Amitié Bangui   (Central African Republic)

^d Hopital Communautaire   (Central African Republic)

^e Maternité des Castors   (Central African Republic)

^f INSTITUT PASTEUR   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIRETROVIRUS AGENT; ISONIAZID; NEVIRAPINE; PROTEINASE; RNA DIRECTED DNA POLYMERASE;

ADOLESCENT; ADULT; ARTICLE; CENTRAL AFRICAN REPUBLIC; ENZYME POLYMORPHISM; FEMALE; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS 1 INFECTION; MAJOR CLINICAL STUDY; MALE; NEWBORN; NUCLEOTIDE SEQUENCE; PREGNANCY; PREVALENCE; PRIORITY JOURNAL; PROPHYLAXIS; TUBERCULOSIS; VERTICAL TRANSMISSION; VIRUS MUTATION; VIRUS STRAIN;

CENTRAL AFRICAN REPUBLIC; DISEASE TRANSMISSION, VERTICAL; DRUG RESISTANCE, VIRAL; FEMALE; HIV PROTEASE; HIV-1; HIV-1 REVERSE TRANSCRIPTASE; HUMANS; MOLECULAR SEQUENCE DATA; POLYMORPHISM, GENETIC; PREGNANCY; PREGNANCY COMPLICATIONS, INFECTIOUS;

EID: 33846196708     PISSN: 08892229     EISSN: None     Source Type: Journal    
DOI: 10.1089/aid.2006.22.1036     Document Type: Article

References (20)

1. Murphy E, Korber B, Georges-Courbot MC, et al.: Diversity of V3 region sequences of human immunodeficiency viruses type 1 from the Central African Republic. AIDS Res Hum Retroviruses 1993;9(10):997-1006.
2. Muller-Trutwin MC, Chaix ML, Letourneur F, et al.: Increased HIV-1 subtype A in central African Republic. J Acquir Immune Defic Syndr 1999;21(2):164-171.
3. Vidal N, Koyalta D, Richard V, et al.: High genetic diversity of HIV strains in Chad, West central Africa. J Acquir Immune Defic Syndr 2003;33(2):239-246.
4. Fonjungo PN, Mpoudi EN, Torimiro JN, et al.: Human immunodeficiency virus type 1 group M protease in Cameroon: Genetic diversity and protease inhibitor mutational features. J Clin Microbiol 2002;40(3):837-845.
5. Njouom R, Pasquier C, Sandres-Sauné K, et al.: Assessment of HIV-1 subtyping for Cameroon strains using phylogenetic analysis of pol gene sequences. J Virol Methods 2003;110:1-8.
6. Ndembi N, Takehisa J, Zekeng L, Kobayashi E, et al.: Genetic diversity of HIV type 1 in rural eastern Cameroon. J Acquir Immune Defic Syndr 2004;37(5):1641-1650.
7. Kita K, Ndembi N, Ekwalanga M, et al.: Genetic diversity of HIV type 1 in Likasi, southeast of the Democratic Republic of Congo. AIDS Res Hum Retroviruses 2004;20(12):1352-1357.
8. Vidal N, Mulanga C, Bazepeo SE, et al.: Distribution of HIV-1 variants in the Democratic Republic of Congo suggest increase of subtype C in Kinshasa between 1997 and 2002. J Acquir Immune Defic Syndr 2005;40(4):456-462.
9. Hierholzer M, Graham RR, El Khidir I, et al.: HIV type 1 strains from East and West Afica are intermixed in Sudan. AIDS Res Hum Retroviruses 2002;18(15):1163-1166.
10. Niama FR, Toure-Kane C, Vidal N, et al.: HIV-1 subtypes and recombinants in the Republic of Congo. Infect Genet Evol 2006;6:337-343.
11. Punzi G, Saracino A, Brindicci G, et al.: HIV infection and protease genetic diversity in a rural area of the southern Central African Republic. J Med Virol 2005;77:457-459.
12. Yang C, Li M, Mokili JLK, et al.: Genetic diversification and recombination of HIV type 1 group M in Kinshasa, Democratic Republic of Congo. AIDS Res Hum Retroviruses 2005;21(7):661-666.
13. Zhong P, Burda S, Konings F, et al.: Genetic and biological properties of HIV type 1 isolates prevalent in villagers of the Cameroon equatorial rain forest and grass fields: Further evidence of broad HIV type 1 genetic diversity. AIDS Res Hum Retroviruses 2003;19(12):1167-1178.
14. Toni TD, Recordon-Pinson P, Minga A, et al.: Presence of key drug resistance mutations in isolates from patients of Abidjan, Côte d'Ivoire: ANRS 1257 study. AIDS Res Hum Retroviruses 2003;19:713-717.
15. Toni T, Adjé-Touré C, Vidal N, et al.: Presence of CRF09_cpx and complex CRF02_AG/CRF09_cpx recombinant HIV type 1 strains in Côte d'Ivoire, West Africa. AIDS Res Hum Retroviruses 2005;21(7):667-672.
16. Thomson MM, Casado G, Posada D, et al.: Identification of a novel HIV-1 complex circulating recombinant form (CRF18_cpx) of central African origin in Cuba. AIDS 2005;19:1155-1163.
17. Casado G, Thomson MM, Sierra M, et al.: Identification of a novel HIV-1 circulating ADG intersubtype recombinant form (CRF19_cpx) in Cuba. J Acquir Immune Defic Syndr 2005;40(5):532-537.
18. Pienazek D, Rayfield M, Hu DJ, et al.: Protease sequences from HIV-1 group M subtypes A-H reveal distinct amino acid mutation patterns associated with protease resistance in protease inhibitor-naive individuals worldwide. HIV Variant Working Group. AIDS 2000;14(11):1489-1495.
19. Fleury H, Recordon-Pinson P, Caumont A, et al.: HIV type 1 diversity in France, 1999-2001: Molecular characterization of non-B HIV type 1 subtypes and potential impact on suceptibility to antiretroviral drugs. AIDS Res Hum Retroviruses 2003;19(1):41-47.
20. Vessière A, Nerrienet E, Kfutwah A, et al.: HIV-1 Pol gene polymorphism and antiretroviral resistance mutations in drug-naive pregnant women in Yaounde, Cameroon. J Acquir Immune Defic Syndr 2006;42:256-258.