Proinsulin C-peptide and insulin: Limited pattern similarities of interest in inter-peptide interactions but no C-peptide effect on insulin and IGF-1 receptor signaling

Cellular and Molecular Life Sciences

Volumn 63, Issue 24, 2006, Pages 3055-3060

  Henriksson, M ^a   Johansson, J ^b   Moede, T ^a   Leibiger, I ^a   Shafqat, J ^a   Berggren, P O ^a   Jornvall H ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

^b SWEDISH UNIVERSITY OF AGRICULTURAL SCIENCES   (Sweden)

Author keywords

IGF 1 receptor; Insulin receptor; Insulin C peptide segment; Proinsulin C peptide; Surface plasmon resonance

Indexed keywords

C PEPTIDE; GLUCOKINASE; INSULIN; INSULIN RECEPTOR; PROINSULIN; SOMATOMEDIN RECEPTOR;

ARTICLE; GENETIC TRANSCRIPTION; INSULIN BINDING; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN INTERACTION; PROTEIN SECONDARY STRUCTURE; SURFACE PLASMON RESONANCE;

AMINO ACID SEQUENCE; ANIMALS; B-LYMPHOCYTES; BINDING SITES; C-PEPTIDE; CELL LINE; CRICETINAE; GLUCOKINASE; INSULIN; MOLECULAR SEQUENCE DATA; PROINSULIN; PROTEIN ISOFORMS; RECEPTOR, IGF TYPE 1; RECEPTOR, INSULIN; SEQUENCE HOMOLOGY, AMINO ACID; SIGNAL TRANSDUCTION; TRANSCRIPTION, GENETIC; TRANSFECTION;

EID: 33846126585     PISSN: 1420682X     EISSN: 15691632     Source Type: Journal    
DOI: 10.1007/s00018-006-6426-7     Document Type: Article

References (34)

1. Shafqat, J., Melles, E., Sigmundsson, K., Johansson, B.-L., Ekberg, K., Alvelius, G., Henriksson, M., Johansson, J., Wahren, J. and Jörnvall, H. (2006) Proinsulin C-peptide elicits disaggregation of insulin resulting in enhanced physiological insulin effects. Cell. Mol. Life Sci. 63, 1805-1811.
2. Rigler, R., Pramanik, A., Jonasson, P., Kratz, G., Jansson, O. T., Nygren, P.-Å., Ståhl, S., Ekberg, K., Johansson, B.-L., Uhlén, S., Uhlén, M., Jörnvall, H. and Wahren, J. (1999) Specific binding of proinsulm C-peptide to human cell membranes. Proc. Natl. Acad. Sci. USA 96, 13318-13323.
3. Al-Rasheed, N. M., Meakin, F., Royal, E. L., Lewington, A. J., Brown, J., Willars, G. B. and Brunskill, N. J. (2004) Potent activation of multiple signalling pathways by C-peptide in opossum kidney proximal tubular cells. Diabetologia 47, 987-997.
4. Ido, Y., Vindigni, A., Chang, K., Stramm, L., Chance, R., Heath, W. F., DiMarchi, R. D., Di Cera, E. and Williamson, J. R. (1997) Prevention of vascular and neural dysfunction in diabetic rats by C-peptide. Science 277, 563-566.
5. Zierath, J. R., Handberg, A., Tally, M. and Wallberg-Henriksson, H. (1996) C-peptide stimulates glucose transport in isolated human skeletal muscle independent of insulin receptor and tyrosine kinase activation. Diabetologia 39, 306-313.
6. Grunberger, G., Qiang, X., Li, Z., Mathews, S. T., Sbrissa, D., Shisheva, A. and Sima, A. A. (2001) Molecular basis for the insulinomimetic effects of C-peptide. Diabetologia 44, 1247-1257.
7. Li, Z. G., Zhang, W. and Sima, A. A. (2003) C-peptide enhances insulin-mediated cell growth and protection against high glucose-induced apoptosis in SH-SY5Y cells. Diabetes Metab. Res. Rev. 19, 375-385.
8. Leibiger, I. B., Leibiger, B. and Berggren, P.-O. (2002) Insulin feedback action on pancreatic β-cell function. FEBS Lett. 532, 1-6.
9. Kulkarni, R. N. (2005) New insights into the roles of insulin/ IGF-I in the development and maintenance of beta-cell mass. Rev. Endocr. Metab. Disord. 6, 199-210.
10. Leibiger, B., Leibiger, I. B., Moede, T., Kemper, S., Kulkarni, R. N., Kahn, C. R., de Vargas, L. M. and Berggren, P.-O. (2001) Selective insulin signaling through A and B insulin receptors regulates transcription of insulin and glucokinase genes in pancreatic beta cells. Mol. Cell 7, 559-570.
11. Yip, C. C. and Ottensmeyer, P. (2003) Three-dimensional structural interactions of insulin and its receptor. J. Biol. Chem. 278, 27329-27332.
12. Henriksson, M., Nordling, E., Melles, E., Shafqat, J., Ståhlberg, M., Ekberg, K., Persson, B., Bergman, T., Wahren, J., Johansson, J. and Jörnvall, H. (2005) Separate functional features of proinsulin C-peptide. Cell. Mol. Life Sci. 62, 1772-1778.
13. Pramanik, A., Ekberg, K., Zhong, Z., Shafqat, J., Henriksson, M., Jansson, O., Ibell, A., Tally, M., Wahren, J. and Jörnvall, H. (2001) C-peptide binding to human cell membranes: importance of Glu27. Biochem. Biophys. Res. Commun. 284, 94-98.
14. Henriksson, M., Shafqat, J., Liepinsh, E., Tally, M., Wahren, J., Jörnvall, H. and Johansson, J. (2000) Unordered structured of proinsulin C-peptide in aqueous solution and in the presence of lipid vesicles. Cell. Mol. Life Sci. 57, 337-342.
15. Munte, C. E., Vilela, L., Kalbitzer, H. R. and Garratt, R. C. (2005) Solution structure of human proinsulin C-peptide. FEBS J. 272, 4284-4293.
16. Fukuhara, A., Matsuda, M., Nishizawa, M., Segawa, K., Tanaka, M., Kishimoto, K., Matsuki, Y., Murakami, M., Ichisaka, T., Murakami, H., Watanabe, E., Takagi, T., Akiyoshi, M., Ohtsubo, T., Kihara, S., Yamashita, S., Makishima, M., Funahashi, T., Yamanaka, S., Hiramatsu, R., Matsuzawa, Y. and Shimomura, I. (2005) Visfatin: a protein secreted by visceral fat that mimics the effects of insulin. Science 307, 426-430.
17. Markussen, J., Halstøm, J., Wiberg, F. C. and Schäffer, L. (1991) Immobilized insulin for high capacity affinity chromatography of insulin receptors. J. Biol. Chem. 266, 18814-18818.
18. Uhles, S., Moede, T., Leibiger, B., Berggren, P.-O. and Leibiger, I. B. (2003) Isoform-specific insulin receptor signaling involves different plasma membrane domains. J. Cell Biol. 163, 1327-1337.
19. Leibiger, I. B., Leibiger, B., Moede, T. and Berggren, P.-O. (1998) Exocytosis of insulin promotes insulin gene transcription via the insulin receptor/PI-3 kinase/p70 s6 kinase and CaM kinase pathways. Mol. Cell 1, 933-938.
20. Schäffer, L. (1994) A model for insulin binding to the insulin receptor. Eur. J. Biochem. 221, 1127-1132.
21. Andersen, A. S., Kjeldsen, T., Wiberg, F. C., Christensen, P. M., Rasmussen, J. S., Norris, K., Møller, K. B. and Møller, N. P. H. (1990) Changing the insulin receptor to possess insulin-like growth factor I ligand specificity. Biochemistry 29, 7363-7366.
22. Sima, A. A., Li, Z. G. and Zhang, W. (2003) The insulin-like growth factor system and neurological complications in diabetes. Exp. Diabetes Res. 4, 235-256.
23. Jansson, M., Hallén, D., Koho, H., Andersson, G., Berghard, L., Heidrich, J., Nyberg, E., Uhlén, M., Kördel, J. and Nilsson, B. (1997) Characterization of ligand binding of a soluble human insulin-like growth factor I receptor variant suggests a ligand-induced conformational change. J. Biol. Chem. 272, 8189-8197.
24. Brandt, J., Andersen, A. S. and Kristensen, C. (2001) Dimeric fragment of the insulin receptor alpha-subunit binds insulin with full holoreceptor affinity. J. Biol. Chem. 276, 12378-12384.
25. Li, S., Termini, J., Hayward, A., Siddle, K., Zick, Y., Koval, A., LeRoith, D. and Fujita-Yamaguchi, Y. (1998) The carboxyl-terminal domain of insulin-like growth factor-I receptor interacts with the insulin receptor and activates its protein tyrosine kinase. FEBS Lett. 421, 45-49.
26. Lawrence, M. C., McGlynn, K., Park, B. H. and Cobb, M. H. (2005) ERK1/2-dependent activation of transcription factors required for acute and chronic effects of glucose on the insulin gene promoter. J. Biol. Chem. 280, 26751-26759.
27. Kitamura, T., Kimura, K., Jung, B. D., Makondo, K., Okamoto, S., Canas, X., Sakane, N., Yoshida, T. and Saito, M. (2001) Proinsulin C-peptide rapidly stimulates mitogen-activated protein kinases in Swiss 3T3 fibroblasts: requirement of protein kinase C, phosphoinositide 3-kinase and pertussis toxin-sensitive G-protein. Biochem. J. 355, 123-129.
28. Kitamura, T., Kimura, K., Jung, B. D., Makondo, K., Sakane, N., Yoshida T. and Saito, M. (2002) Proinsulin C-peptide activates cAMP response element-binding proteins through the p38 mitogen-activated protein kinase pathway in mouse lung capillary endothelial cells. Biochem. J. 366, 737-744.
29. Kitamura, T., Kimura, K., Makondo, K., Furuya, D. T., Suzuki, M., Yoshida, T. and Saito, M. (2003) Proinsulin C-peptide increases nitric oxide production by enhancing mitogen-activated protein-kinase-dependent transcription of endothelial nitric oxide synthase in aortic endothelial cells of Wistar rats. Diabetologia 46, 1698-1705.
30. Zhong, Z., Davidescu, A., Ehrén, I., Ekberg, K., Jörnvall, H., Wahren, J. and Chibalin, A. V. (2005) C-peptide stimulates ERK1/2 and JNK MAP kinases via activation of protein kinase C in human renal tubular cells. Diabetologia 48, 187-197.
31. Kobayashi, Y., Naruse, K., Hamada, Y., Nakashima, E., Kato, K., Akiyama, N., Kamiya, H., Watarai, A., Nakae, M., Oiso, Y. and Nakamura, J. (2005) Human proinsulin C-peptide prevents proliferation of rat aortic smooth muscle cells cultured in high-glucose conditions. Diabetologia 48, 2396-2401.
32. 2+ increases in human renal tubular cells. Cell. Mol. Life Sci. 59, 1185-1189.
33. Wallerath, T., Kunt, T., Forst, T., Closs, E. I., Lehmann, R., Flohr, T., Gabriel, M., Schafer, D., Gopfert, A., Pfützner, A., Beyer, J. and Forsermann, U. (2003) Stimulation of endothelial nitric oxide synthase by proinsulin C-peptide. Nitric Oxide 9, 95-102.
34. Li, Z. G., Qiang, X., Sima, A. A. and Grunberger, G. (2001) C-peptide attenuates protein tyrosine phosphatase activity and enhances glycogen synthesis in L6 myoblasts. Biochem. Biophys. Res. Commun. 280, 615-619.