A pilot study on the infiltrating cells and cytokine levels in the tear of fungal keratitis patients

Indian Journal of Ophthalmology

Volumn 55, Issue 1, 2007, Pages 27-31

  Vasanthi, Mani ^a   Prajna, Namperumalsamy Venkatesh ^b   Lalitha, Prajna ^b   Mahadevan, Kannan ^c   Muthukkaruppan, Veerappan ^a  

^a ARAVIND MEDICAL RESEARCH FOUNDATION   (India)

^b ARAVIND EYE CARE SYSTEM   (India)

^c Lions Aravind Institute of Community Ophthalmology   (India)

Author keywords

Cytokines; Fungal Keratitis; Infiltrating cells; Tear

Indexed keywords

CYTOKINE; INTERLEUKIN 1BETA; INTERLEUKIN 6; INTERLEUKIN 8;

ADULT; ARTICLE; CATARACT EXTRACTION; CELL INFILTRATION; CLINICAL ARTICLE; CONJUNCTIVITIS; CONTROLLED STUDY; COURSE EVALUATION; CYTOKINE PRODUCTION; DISEASE COURSE; ENZYME IMMUNOASSAY; HEALING; HUMAN; INFLAMMATORY INFILTRATE; KERATOMYCOSIS; LACRIMAL FLUID; LYMPHOCYTIC INFILTRATION; MALE; NEUTROPHIL; NEUTROPHIL CHEMOTAXIS; NONPARAMETRIC TEST; STATISTICAL ANALYSIS;

EID: 33846118351     PISSN: 03014738     EISSN: 03014738     Source Type: Journal    
DOI: 10.4103/0301-4738.29491     Document Type: Article

References (30)

1. Whitcher JP, Srinivasan M. Corneal ulceration in the developing world-A silent epidemic. Br J Ophthalmol 1997;81:622-3.
2. Prajna NV, John RK, Nirmalan PK, Lalitha P, Srinivasan M. A randomised clinical trial comparing 2% econazole and 5% natamycin for the treatment of fungal keratitis. Br J Ophthalmol 2003;87:1235-7.
3. Thomas PA. Current perspectives on ophthalmic mycoses. Clin Microbiol Rev 2003;16:730-7.
4. Dana RM, Qian Y, Hamrah P. Twenty-five-year panorama of corneal immunology- emerging concepts in the immunopathogenesis of microbial keratitis, peripheral ulcerative keratitis and corneal transplant rejection. Cornea 2000;19:625-3.
5. Staats HF, Lausch RN. Cytokine expression in vivo during murine herpetic stromal keratitis. Effect of protective antibody therapy. J Immunol 1993;151:277-3.
6. Stumpf TH, Shimeld C, Easty DL, Hill TJ. Cytokine production in a murine model of recurrent herpetic stromal keratitis. Invest Ophthalmol Vis Sci 2001;42:372-8.
7. Xue ML, Willcox MD, Lloyd A, Wakefield D, Takur A. Regulatory role of IL-1beta in the expression of IL-6 and IL-8 in human corneal epithelial cells during Pseudomonas aeruginosa colonization. Clin Exp Ophthalmol 2001;29:171-4.
8. Becker J, Salla S, Dohman U, Redbrake C, Reim M. Explorative study of interleukin levels in the human cornea. Graef's Arch Clin Exp Ophthalmol 1995;233:766-71.
9. Wu TG, Wilhelmus KR, Mitchell BM. Experimental keratomycosis in a mouse model. Invest Ophthalmol Vis Sci 2003;44:210-6.
10. Wu TG, Keasler VV, Mitchell BM, Wilhelmus KR. Immunosuppression affects the severity of experimental Fusarium solani keratitis. J Infect Dis 2004;190:192-8.
11. Choy CK, Cho P, Chung WY, Benzie IF. Water-soluble antioxidants in human tears: effect of the collection method. Invest Ophthalmol Vis Sci 2001;42:3130-4.
12. Zierhut M, Dana RM, Stern ME, Sullivan DA. Immunology of the lacrimal gland and ocular tear film. Trends Immunol 2002;23:333-5.
13. Leonardi A, Brun P, Abatangelo G, Plebani M, Seccgi AG. Tear levels and activity of matrix metalloproteinases (MMP)-1 and MMP-9 in vernal keratoconjunctivitis. Invest Ophthalmol Vis Sci 2003;44:3052-8.
14. Priya CG, Bhavani K, Rathinam SR, Muthukkaruppan VR. Identification and evaluation of LPS antigen for serodiagnosis of uveitis associated with leptospirosis. J Med Microbiol 2003;52:667-73.
15. Bradford MM. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 1976;72:248-54.
16. Barton K, Monroy DC, Nava A, Pfluggelder SC. Inflammatory cytokines in the tears of patients with ocular rosacea. Ophthalmology 1997;104:1868-74.
17. Poole TR, Hunter DL, Maliwa EM, Ramsay AR. Aetiology of microbial keratitis in northern Tanzania. Br J Ophthalmol 2002;86:941-2.
18. Alekseev VN, Ketlinskaia OS, Gruzinova TL. Cytokines in the tear fluid and their role in the pathogenesis of ophthalmic herpes. Vestn Ross Akad Med Nauk 1996;1:57-9.
19. Vesaluamo MH, Tervo TT. Tenascin and cytok ines in tear fluid after photorefractive keratectomy. J Refract Surg 1998;14:447-54.
20. Sloop GD, Moreau JM, Conerly LL, Dajcs JJ, O'Callaghan RJ. Acute inflammation of the eyelid and cornea in Staphylococcus keratitis in the rabbit. Invest Ophthalmol Vis Sci 1999;40:385-91.
21. Thomas J, Gangappa S, Kanangat S, Rouse BJ. On the essential involvement of neutrophils in the immunopathologic disease-Herpetic Stromal Keratitis. J Immunol 1997;158:1383-91.
22. Gopinathan U, Ramakrishna T, Willcox M, Rao CM, Balasubramanian D, Kulkarni A, et al. Enzymatic, clinical and histologic evaluation of corneal tissues in experimental fungal keratitis in rabbits. Exp Eye Res 2001;72:433-42.
23. Nakamura Y, Sotozono C, Kinoshita S. Inflammatory cytokines in normal human tears. Curr Eye Res 1998;17:673-6.
24. Fenton RR, Molesworth-Kenyon S, Oakes JE, Lausch RN. Linkage of IL-6 with neutrophil chemo attractant expression in virus-induced ocular inflammation. Invest Ophthalmol Vis Sci 2002;43:737-43.
25. Kernacki KA, Goebel DJ, Poosch MS, Hazlett LD. Early cytokine and chemokine gene expression during Pseudomonas aeruginosa corneal infection in mice. Infect Immunol 1998;66:376-9.
26. Borish L, Rosenbaum R, Albury L, Clark S. Activation of neutrophils by recombinant interleukin 6. Cell Immunol 1989;121:280-9.
27. Chodosh J, Astley RA, Butler MG, Kennedy RC. Adenovirus keratitis: A role for interleukin-8. Invest Ophthalmol Vis Sci 2000;41:783-9.
28. Oakes JE, Monteiro CA, Cubitt CL, Lausch RN. Induction of interleukin-8 gene expression is associated with herpes simplex virus infection of human corneal keratocytes but not human corneal epithelial cells. J Virol 1993;67:4777-84.
29. Dinarello CA. Biologic basis for interleukin-1 in disease. Blood 1996;87:2095-147.
30. Rudner XL, Kernacki KA, Barrett RP, Hazlett LD. Prolonged elevation of IL-1in Pseudomonas aeruginosa ocular infection regulates macrophage-inflammatory protein-2 production, polymorphonuclear neutrophil persistence and corneal perforation. J Immunol 2000;164:6576-82.