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Volumn 66, Issue 18, 2006, Pages 2371-2381

Recombinant full-length parathyroid hormone (1-84)

Author keywords

[No Author keywords available]

Indexed keywords

ALENDRONIC ACID; BISPHOSPHONIC ACID DERIVATIVE; CALCITONIN; CALCIUM; IBANDRONIC ACID; PARATHYROID HORMONE[1-34]; PLACEBO; PREOTACT; RALOXIFENE; RECOMBINANT PARATHYROID HORMONE; RISEDRONIC ACID; UNCLASSIFIED DRUG; VITAMIN D;

EID: 33846107351     PISSN: 00126667     EISSN: 00126667     Source Type: Journal    
DOI: 10.2165/00003495-200666180-00008     Document Type: Review
Times cited : (26)

References (34)
  • 1
    • 31044432767 scopus 로고    scopus 로고
    • Pathogenesis of osteoporosis: Concepts, conflicts, and prospects
    • Dec;
    • Raisz LG. Pathogenesis of osteoporosis: concepts, conflicts, and prospects. J Clin Invest 2005 Dec; 115 (12): 3318-25
    • (2005) J Clin Invest , vol.115 , Issue.12 , pp. 3318-3325
    • Raisz, L.G.1
  • 2
    • 13244273552 scopus 로고    scopus 로고
    • Treatment of patients with postmenopausal osteoporosis is worthwhile. The position of the International Osteoporosis Foundation
    • Jan;
    • Delmas PD, Rizzoli R, Cooper C, et al. Treatment of patients with postmenopausal osteoporosis is worthwhile. The position of the International Osteoporosis Foundation. Osteoporos Int 2005 Jan; 16 (1): 1-5
    • (2005) Osteoporos Int , vol.16 , Issue.1 , pp. 1-5
    • Delmas, P.D.1    Rizzoli, R.2    Cooper, C.3
  • 3
    • 9344220503 scopus 로고    scopus 로고
    • Parathyroid hormone for the treatment of osteoporosis
    • McClung M. Parathyroid hormone for the treatment of osteoporosis. Obstet Gynecol Surv 2004; 59 (12): 826-32
    • (2004) Obstet Gynecol Surv , vol.59 , Issue.12 , pp. 826-832
    • McClung, M.1
  • 4
    • 13444260744 scopus 로고    scopus 로고
    • Parathyroid hormone secretion and action: Evidence for discrete receptors for the carboxyl-terminal region and related biological actions of carboxyl-terminal ligands
    • Feb;
    • Murray TM, Rao LG, Divieti P, et al. Parathyroid hormone secretion and action: evidence for discrete receptors for the carboxyl-terminal region and related biological actions of carboxyl-terminal ligands. Endocr Rev 2005 Feb; 26 (1): 78-113
    • (2005) Endocr Rev , vol.26 , Issue.1 , pp. 78-113
    • Murray, T.M.1    Rao, L.G.2    Divieti, P.3
  • 5
    • 29644433621 scopus 로고    scopus 로고
    • Parathyroid hormone: Past and present
    • Dec;
    • Potts JT. Parathyroid hormone: past and present. J Endocrinol 2005 Dec; 187 (3): 311-25
    • (2005) J Endocrinol , vol.187 , Issue.3 , pp. 311-325
    • Potts, J.T.1
  • 6
    • 33646042270 scopus 로고    scopus 로고
    • The roles of parathyroid hormone and calcitonin in bone remodeling: Prospects for novel therapeutics
    • Mar;
    • Carter PH, Schipani E. The roles of parathyroid hormone and calcitonin in bone remodeling: prospects for novel therapeutics. Endocr Metab Immune Disord Drug Targets 2006 Mar; 6 (1): 59-76
    • (2006) Endocr Metab Immune Disord Drug Targets , vol.6 , Issue.1 , pp. 59-76
    • Carter, P.H.1    Schipani, E.2
  • 7
    • 0038684153 scopus 로고    scopus 로고
    • Parathyroid hormone, its fragments and their analogs for the treatment of osteoporosis
    • Whitfield JF, Morley P, Willick GE. Parathyroid hormone, its fragments and their analogs for the treatment of osteoporosis. Treat Endocrinol 2002; 1 (3): 175-90
    • (2002) Treat Endocrinol , vol.1 , Issue.3 , pp. 175-190
    • Whitfield, J.F.1    Morley, P.2    Willick, G.E.3
  • 9
    • 0030897225 scopus 로고    scopus 로고
    • Single-dose subcutaneous administration of recombinant human parathyroid hormone [rhPTH(1-84)] in healthy postmenopausal volunteers
    • Mar;
    • Schwietert HR, Groen EWJ, Sollie FAE, et al. Single-dose subcutaneous administration of recombinant human parathyroid hormone [rhPTH(1-84)] in healthy postmenopausal volunteers. Clin Pharmacol Ther 1997 Mar; 61: 360-76
    • (1997) Clin Pharmacol Ther , vol.61 , pp. 360-376
    • Schwietert, H.R.1    Groen, E.W.J.2    Sollie, F.A.E.3
  • 10
    • 0042193403 scopus 로고
    • Multiple dose administration of recombinant human parathyroid hormone (rhPTH (1-84)) in healthy postmenopausal volunteers [abstract no. 525]
    • Groen EWJ, Schwietert HR, Van Marle SP, et al. Multiple dose administration of recombinant human parathyroid hormone (rhPTH (1-84)) in healthy postmenopausal volunteers [abstract no. 525]. Therapie 1995; 50 Suppl.
    • (1995) Therapie , vol.50 , Issue.SUPPL.
    • Groen, E.W.J.1    Schwietert, H.R.2    Van Marle, S.P.3
  • 11
    • 0345305666 scopus 로고    scopus 로고
    • Efficacy and safety of human parathyroid hormone-(1-84) in increasing bone mineral density in postmenopausal osteoporosis
    • Nov;
    • Hodsman AB, Hanley DA, Ettinger MP, et al. Efficacy and safety of human parathyroid hormone-(1-84) in increasing bone mineral density in postmenopausal osteoporosis. J Clin Endocrinol Metab 2003 Nov; 88 (11): 5212-20
    • (2003) J Clin Endocrinol Metab , vol.88 , Issue.11 , pp. 5212-5220
    • Hodsman, A.B.1    Hanley, D.A.2    Ettinger, M.P.3
  • 12
    • 0141684971 scopus 로고    scopus 로고
    • The effects of parathyroid hormone and alendronate alone or in combination in postmenopausal osteoporosis
    • Sep 25;
    • Black DM, Greenspan SL, Ensrud KE, et al. The effects of parathyroid hormone and alendronate alone or in combination in postmenopausal osteoporosis. N Engl J Med 2003 Sep 25; 349 (13): 1207-15
    • (2003) N Engl J Med , vol.349 , Issue.13 , pp. 1207-1215
    • Black, D.M.1    Greenspan, S.L.2    Ensrud, K.E.3
  • 13
    • 33846038005 scopus 로고    scopus 로고
    • Treatment of osteopenic rhesus monkeys with parathyroid hormone 1-84 for 16 months improves vertebral trabecular bone quantity and quality [abstract no. M415]
    • Sep;
    • Moreau IA, Smith SY, Guldberg RE, et al. Treatment of osteopenic rhesus monkeys with parathyroid hormone 1-84 for 16 months improves vertebral trabecular bone quantity and quality [abstract no. M415]. J Bone Miner Res 2005 Sep; 20 Suppl. 1: S412
    • (2005) J Bone Miner Res , vol.20 , Issue.SUPPL. 1
    • Moreau, I.A.1    Smith, S.Y.2    Guldberg, R.E.3
  • 14
    • 0027514232 scopus 로고
    • The effect of recombinant human (1-84) or synthetic human (1-34) parathyroid hormone on the skeleton of adult osteopenic ovariectomized rats
    • Apr;
    • Kimmel DB, Bozzato RP, Kronis KA, et al. The effect of recombinant human (1-84) or synthetic human (1-34) parathyroid hormone on the skeleton of adult osteopenic ovariectomized rats. Endocrinology 1993 Apr; 132 (4): 1577-84
    • (1993) Endocrinology , vol.132 , Issue.4 , pp. 1577-1584
    • Kimmel, D.B.1    Bozzato, R.P.2    Kronis, K.A.3
  • 15
    • 0031016663 scopus 로고    scopus 로고
    • 2 to stimulate femoral trabecular bone growth in ovariectomized rats
    • Jan;
    • 2 to stimulate femoral trabecular bone growth in ovariectomized rats. Calcif Tissue Int 1997 Jan; 60 (1): 26-9
    • (1997) Calcif Tissue Int , vol.60 , Issue.1 , pp. 26-29
    • Whitfield, J.F.1    Morley, P.2    Willick, G.E.3
  • 16
    • 0027317601 scopus 로고
    • Human parathyroid hormone (1-34) and (1-84) increase the mechanical strength and thickness of cortical bone in rats
    • Sep;
    • Ejersted C, Andreassen TT, Oxlund H, et al. Human parathyroid hormone (1-34) and (1-84) increase the mechanical strength and thickness of cortical bone in rats. J Bone Miner Res 1993 Sep; 8 (9): 1097-101
    • (1993) J Bone Miner Res , vol.8 , Issue.9 , pp. 1097-1101
    • Ejersted, C.1    Andreassen, T.T.2    Oxlund, H.3
  • 17
    • 0035129745 scopus 로고    scopus 로고
    • Maintenance of cortical bone in human parathyroid hormone(1-84)-treated ovariectomized rats
    • Mar;
    • Samnegard E, Iwaniec UT, Cullen DM, et al. Maintenance of cortical bone in human parathyroid hormone(1-84)-treated ovariectomized rats. Bone 2001 Mar; 28 (3): 251-60
    • (2001) Bone , vol.28 , Issue.3 , pp. 251-260
    • Samnegard, E.1    Iwaniec, U.T.2    Cullen, D.M.3
  • 18
    • 33846096608 scopus 로고    scopus 로고
    • NPS Pharmaceuticals. NPS reports positive PREOS study results [online]. Available from URL: http://www.npsp.com [Accessed 2006 Jun 14]
    • NPS Pharmaceuticals. NPS reports positive PREOS study results [online]. Available from URL: http://www.npsp.com [Accessed 2006 Jun 14]
  • 19
    • 33846064469 scopus 로고    scopus 로고
    • A no observable carcinogenic effect dose level identified in Fischer 344 rats following daily treatment with PTH(1-84) for 2 years: Role of the c-terminal PTH receptor?
    • May 10-14; Prague
    • Fox J, Smith S, Jolette J, et al. A no observable carcinogenic effect dose level identified in Fischer 344 rats following daily treatment with PTH(1-84) for 2 years: role of the c-terminal PTH receptor? 33rd European Symposium on Calcified Tissues; 2006 May 10-14; Prague
    • (2006) 33rd European Symposium on Calcified Tissues
    • Fox, J.1    Smith, S.2    Jolette, J.3
  • 20
    • 0036001310 scopus 로고    scopus 로고
    • Skeletal changes in rats given daily subcutaneous injections of recombinant human parathyroid hormone (1-34) for 2 years and relevance to human safety
    • May-Jun;
    • Vahle JL, Sato M, Long GG, et al. Skeletal changes in rats given daily subcutaneous injections of recombinant human parathyroid hormone (1-34) for 2 years and relevance to human safety. Toxicol Pathol 2002 May-Jun; 30 (3): 312-21
    • (2002) Toxicol Pathol , vol.30 , Issue.3 , pp. 312-321
    • Vahle, J.L.1    Sato, M.2    Long, G.G.3
  • 22
    • 33646807061 scopus 로고    scopus 로고
    • Preventing the first vertebral fracture in postmenopausal women with low bone mass using PTH(1-84): Results from the TOP study [abstract no. 1222]
    • Sep;
    • Greenspan SL, Bone HG, Marriott TB, et al. Preventing the first vertebral fracture in postmenopausal women with low bone mass using PTH(1-84): results from the TOP study [abstract no. 1222]. J Bone Miner Res 2005 Sep; 20 Suppl. 1: S56
    • (2005) J Bone Miner Res , vol.20 , Issue.SUPPL. 1
    • Greenspan, S.L.1    Bone, H.G.2    Marriott, T.B.3
  • 23
    • 33846074199 scopus 로고    scopus 로고
    • PTH(1-84) prevents vertebral fractures in post menopausal women with higher fracture risk: Results from the TOP study
    • abstract no. P425, May 10-14; Prague
    • Miller PD. PTH(1-84) prevents vertebral fractures in post menopausal women with higher fracture risk: results from the TOP study [abstract no. P425]. 33rd European Symposium on Calcified Tissues; 2006 May 10-14; Prague
    • (2006) 33rd European Symposium on Calcified Tissues
    • Miller, P.D.1
  • 24
    • 33645362388 scopus 로고    scopus 로고
    • Effects of parathyroid hormone 1-84 on cortical and trabecular bone at the hip as assessed by QCT: Results at 18 months from the TOP Study [abstract no. 1083]
    • Sep;
    • Bogado CE, Zanchetta JR, Mango A, et al. Effects of parathyroid hormone 1-84 on cortical and trabecular bone at the hip as assessed by QCT: results at 18 months from the TOP Study [abstract no. 1083]. J Bone Miner Res 2005 Sep; 20 Suppl. 1: S22
    • (2005) J Bone Miner Res , vol.20 , Issue.SUPPL. 1
    • Bogado, C.E.1    Zanchetta, J.R.2    Mango, A.3
  • 25
    • 33846045398 scopus 로고    scopus 로고
    • Treatment of postmenopausal osteoporotic women with parathyroid hormone (1-84) for 18 months decreases BMD but does not affect indices of bone strength at the distal radius [abstract no. F383]
    • Bogado CE, Zanchetta JR, Gordon CL, et al. Treatment of postmenopausal osteoporotic women with parathyroid hormone (1-84) for 18 months decreases BMD but does not affect indices of bone strength at the distal radius [abstract no. F383]. J Bone Miner Res 2006; 21 Suppl. 1
    • (2006) J Bone Miner Res , vol.21 , Issue.SUPPL. 1
    • Bogado, C.E.1    Zanchetta, J.R.2    Gordon, C.L.3
  • 26
    • 33846097024 scopus 로고    scopus 로고
    • Recombinant human parathyroid hormone 1-84 (PTH) reduces the incidence of multiple new vertebral fractures and new fracture severity in postmenopausal osteoporotic women [abstract no. P321MO]
    • Ettinger MP, Marriott TB. Recombinant human parathyroid hormone 1-84 (PTH) reduces the incidence of multiple new vertebral fractures and new fracture severity in postmenopausal osteoporotic women [abstract no. P321MO]. Osteoporos Int 2006; 17 Suppl. 2: S90
    • (2006) Osteoporos Int , vol.17 , Issue.SUPPL. 2
    • Ettinger, M.P.1    Marriott, T.B.2
  • 28
    • 23444452077 scopus 로고    scopus 로고
    • One year of alendronate after one year of parathyroid hormone (1-84) for osteoporosis
    • Aug 11;
    • Black DM, Bilezikian JP, Ensrud KE, et al. One year of alendronate after one year of parathyroid hormone (1-84) for osteoporosis. N Engl J Med 2005 Aug 11; 353 (6): 555-65
    • (2005) N Engl J Med , vol.353 , Issue.6 , pp. 555-565
    • Black, D.M.1    Bilezikian, J.P.2    Ensrud, K.E.3
  • 29
    • 33745112512 scopus 로고    scopus 로고
    • Safety and efficacy of PTH(1-84) at 18 and 24 months in women with postmenopausal osteoporosis receiving hormone therapy: Results from the POWER study [abstract no. 1080]
    • Sep;
    • Fogelman I, Christiansen C, Spector T, et al. Safety and efficacy of PTH(1-84) at 18 and 24 months in women with postmenopausal osteoporosis receiving hormone therapy: results from the POWER study [abstract no. 1080]. J Bone Miner Res 2005 Sep; 20 Suppl. 1: S21-2
    • (2005) J Bone Miner Res , vol.20 , Issue.SUPPL. 1
    • Fogelman, I.1    Christiansen, C.2    Spector, T.3
  • 30
    • 34047237482 scopus 로고    scopus 로고
    • European Medicines Agency, discussion Preotact, online, Available from URL:, Accessed May 31
    • European Medicines Agency. Scientific discussion (Preotact) [online]. Available from URL: http://www.emea.eu.int/humandocs/PDFs/EPAR/preotact/ PreotactEparScientificDen.pdf [Accessed 2006 May 31]
    • (2006) Scientific
  • 31
    • 33846114029 scopus 로고    scopus 로고
    • Bone turnover markers and BMD remain elevated in postmenopausal osteoporotic women through a full 24 months of treatment with human parathyroid hormone 1-84 (PTH)
    • abstract no. F389, Sep 15-19; Philadelphia PA
    • Greenspan SL, Hanley DA, Morris S, et al. Bone turnover markers and BMD remain elevated in postmenopausal osteoporotic women through a full 24 months of treatment with human parathyroid hormone 1-84 (PTH) [abstract no. F389]. 28th Annual Meeting of the American Society for Bone and Mineral Research; 2006 Sep 15-19; Philadelphia (PA)
    • (2006) 28th Annual Meeting of the American Society for Bone and Mineral Research
    • Greenspan, S.L.1    Hanley, D.A.2    Morris, S.3
  • 33
    • 33846054239 scopus 로고    scopus 로고
    • Parathyroid hormone (1-84) is effective in patients with a wide range of clinical risk factors
    • abstract no. OP0126, Jun 21-24; Amsterdam
    • Compston J, Silverman S, Mathisen A, et al. Parathyroid hormone (1-84) is effective in patients with a wide range of clinical risk factors [abstract no. OP0126]. 2006 Annual European Congress of Rheumatology; 2006 Jun 21-24; Amsterdam
    • (2006) 2006 Annual European Congress of Rheumatology
    • Compston, J.1    Silverman, S.2    Mathisen, A.3
  • 34
    • 33644547976 scopus 로고    scopus 로고
    • Treatment of postmenopausal osteoporotic women with parathyroid hormone 1-84 for 18 months increases cancellous bone formation and improves cancellous architecture: A study of iliac crest biopsies using histomorphometry and micro computed tomography
    • Dec;
    • Fox J, Miller MA, Recker RR, et al. Treatment of postmenopausal osteoporotic women with parathyroid hormone 1-84 for 18 months increases cancellous bone formation and improves cancellous architecture: A study of iliac crest biopsies using histomorphometry and micro computed tomography. J Musculoskelet Neuronal Interact 2005 Dec; 5 (4): 356-7
    • (2005) J Musculoskelet Neuronal Interact , vol.5 , Issue.4 , pp. 356-357
    • Fox, J.1    Miller, M.A.2    Recker, R.R.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.