Efficacy of warfarin reversal in orthopedic trauma surgery patients

Journal of Orthopaedic Trauma

Volumn 21, Issue 1, 2007, Pages 26-30

  Tharmarajah, Pritam ^a   Pusey, Jane ^a   Keeling, David ^a   Willett, Keith ^a  

^a JOHN RADCLIFFE HOSPITAL   (United Kingdom)

Author keywords

Orthopaedic trauma surgery; Reversal; Vitamin K; Warfarin

Indexed keywords

VITAMIN K GROUP; WARFARIN;

ANTICOAGULATION; ARTICLE; CASE STUDY; CLINICAL ARTICLE; CLINICAL TRIAL; COHORT ANALYSIS; COMPARATIVE STUDY; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG COST; DRUG EFFICACY; EMERGENCY HEALTH SERVICE; HOSPITAL BED; HUMAN; INJURY; INTERNATIONAL NORMALIZED RATIO; LOADING DRUG DOSE; OPERATION DURATION; POSTOPERATIVE PERIOD; PRIORITY JOURNAL; RETROSPECTIVE STUDY; SURGICAL PATIENT; TREATMENT OUTCOME; TREATMENT WITHDRAWAL; UNIVERSITY HOSPITAL;

ADMINISTRATION, ORAL; ANTICOAGULANTS; BLOOD COAGULATION; BLOOD COAGULATION DISORDERS; COHORT STUDIES; DRUG ADMINISTRATION SCHEDULE; FEMALE; HUMANS; INJECTIONS, INTRAVENOUS; MALE; ORTHOPEDIC PROCEDURES; PREOPERATIVE CARE; THROMBOSIS; TREATMENT OUTCOME; VITAMIN K; WARFARIN; WOUNDS AND INJURIES;

EID: 33846098311     PISSN: 08905339     EISSN: None     Source Type: Journal    
DOI: 10.1097/BOT.0b013e31802c4f3c     Document Type: Article

References (16)

1. Salamat A, Seaton J, Watson HG. Impact of introducing guidelines on anticoagulant reversal. Transfus Med. 2005;15:99-105.
2. Baglin TP, Keeling DM, Watson HG. Guidelines on oral anticoagulation (warfarin): third edition: 2005 update. Br J Haematol. 2006;132:277-285.
3. Francis CW, Marder VJ, Evarts CM, et al. Two-step warfarin therapy: prevention of postoperative venous thrombosis without excessive bleeding. JAMA. 1983;249:374-378.
4. Carrel TP, Klingenmann W, Mohacsi PJ, et al. Perioperative bleeding and thromboembolic risk during non-cardiac surgery in patients with mechanical prosthetic heart valves: an institutional review. J Heart Valve Dis. 1999;8:392-398.
5. Gallus AS, Baker RI, Chong BH, et al. Consensus guidelines for warfarin therapy: recommendations from the Australasian Society of Thrombosis and Haemostasis. Med J Aust. 2000;172:600-605.
6. Sandset PM, Abildgaard U. Perioperative management of oral anticoagulant therapy. Thromb Res. 2002;108:1-2.
7. Al-Rashid M, Parker MJ. Anticoagulation management in hip fracture patients on warfarin. Injury. 2005;36:1311-1315.
8. Ezekowitz MD, Netrebko PI. Anticoagulation in management of atrial fibrillation. Curr Opin Cardiol. 2003;18:26-31.
9. Loebstein R, Yonath H, Peleg D, et al. Interindividual variability in sensitivity to warfarin: nature or nurture? Clin Pharmacol Ther. 2001;70:159-164.
10. Paul B, Oxley A, Brigham K, et al. Factor II, VII, IX and X concentrations in patients receiving long term warfarin. J Clin Pathol. 1987;40:94-98.
11. Cosgriff SW. The effectiveness of an oral vitamin K1 in controlling excessive hypoprothrombinemia during anticoagulant therapy. Ann Intern Med. 1956;45:14-22.
12. Pengo V, Banzato A, Garelli E, et al. Reversal of excessive effect of regular anticoagulation: low oral dose of phytonadione (vitamin K1) compared with warfarin discontinuation. Blood Coagul Fibrinolysis. 1993;4:739-741.
13. White RH, McKittrick T, Hutchinson R, et al. Temporary discontinuation of warfarin therapy: changes in the international normalized ratio. Ann Intern Med. 1995;122:40-42.
14. Watson HG, Baglin T, Laidlaw SL, et al. A comparison of the efficacy and rate of response to oral and intravenous vitamin K in reversal of over-anticoagulation with warfarin. Br J Haematol. 2001;115:145-149.
15. Hanley JP. Warfarin reversal. J Clin Pathol. 2004;57:1132-1139.
16. Shields RC, McBane RD, Kuiper JD, et al. Efficacy and safety of intravenous phytonadione (vitamin K1) in patients on long-term oral anticoagulant therapy. Mayo Clin Proc. 2001;76:260-266.