Anti-IgA antibodies in Common Variable Immunodeficiency (CVID): Diagnostic workup and therapeutic strategy

Clinical Immunology

Volumn 122, Issue 2, 2007, Pages 156-162

  Horn, Julia ^a   Thon, Vojtech ^b   Bartonkova, Dana ^b   Salzer, Ulrich ^a   Warnatz, Klaus ^a   Schlesier, Michael ^a   Peter, Hans Hartmut ^a   Grimbacher, Bodo ^a  

^a UNIVERSITY OF FREIBURG   (Germany)

^b ST ANNE S UNIVERSITY HOSPITAL   (Czech Republic)

Author keywords

Anaphylactoid reaction; Class switched CD27pos IgMneg IgDneg memory B cells; Common Variable Immunodeficiency (CVID); Freiburg CVID classification; IgA deficiency; IgA+ B cells; IgG anti IgA antibodies; Intravenous immunoglobulin replacement therapy (IVIG); Subcutaneous immunoglobulin replacement therapy (SCIG)

Indexed keywords

ADRENALIN; ANTIBIOTIC AGENT; ANTIHISTAMINIC AGENT; BERIGLOBIN; CD27 ANTIGEN; CORTICOSTEROID; DEXAMETHASONE; ENDOBULINIV; GAMMA VENIN; GAMMANORM; GAMMAVENIN; HUMAN IMMUNOGLOBULIN; IMMUNOGLOBULIN; IMMUNOGLOBULIN A; IMMUNOGLOBULIN A ANTIBODY; IMMUNOGLOBULIN D; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; PREDNISOLONE; SUBCUVIA; UNCLASSIFIED DRUG;

ACUTE KIDNEY FAILURE; ADULT; ANAPHYLAXIS; ARTICLE; AUTOIMMUNITY; B LYMPHOCYTE; BLOOD; BRONCHUS DISEASE; BRONCHUS EDEMA; CAPILLARY LEAK SYNDROME; CHEST TIGHTNESS; CHILL; CLINICAL ARTICLE; COMMON VARIABLE IMMUNODEFICIENCY; COUGHING; CYANOSIS; DISEASE PREDISPOSITION; DRUG ERUPTION; DRUG FEVER; DRUG WITHDRAWAL; DYSPNEA; EDEMA; FEMALE; FLUSHING; GRANULOMATOSIS; HUMAN; HUMAN CELL; HYPERPLASIA; HYPOTENSION; IMMUNOGLOBULIN DEFICIENCY; LOBAR PNEUMONIA; LUNG EDEMA; LYMPHOCYTE PROLIFERATION; MALE; MEMORY CELL; MOUTH EDEMA; NOSE EDEMA; PALATE DISEASE; PHENOTYPE; PRIORITY JOURNAL; PRURITUS; RISK; SIDE EFFECT; SUBSTITUTION THERAPY; UNCONSCIOUSNESS; UVULA SWELLING;

ADULT; ANAPHYLAXIS; ANTIBODIES, ANTI-IDIOTYPIC; COMMON VARIABLE IMMUNODEFICIENCY; FEMALE; HUMANS; IMMUNOGLOBULIN A; IMMUNOGLOBULIN G; IMMUNOGLOBULINS, INTRAVENOUS; MALE; MIDDLE AGED;

EID: 33846096807     PISSN: 15216616     EISSN: 15217035     Source Type: Journal    
DOI: 10.1016/j.clim.2006.10.002     Document Type: Article

References (21)

1. Hammarstrom L., Persson M.A., and Smith C.I. Anti-IgA in selective IgA deficiency, in vitro effects and Ig subclass pattern of human anti-IgA. Scand. J. Immunol. 18 (1983) 509-513
2. Bjorkander J., Hammarstrom L., Smith C.I., Buckley R.H., Cunningham-Rundles C., and Hanson L.A. Immunoglobulin prophylaxis in patients with antibody deficiency syndromes and anti-IgA antibodies. J. Clin. Immunol. 7 (1987) 8-15
3. de Albuquerque Campos R., Sato M.N., and da Silva Duarte A.J. IgG anti-IgA subclasses in common variable immunodeficiency and association with severe adverse reactions to intravenous immunoglobulin therapy. J. Clin. Immunol. 20 (2000) 77-82
4. Lilic D., and Sewell W.A.C. IgA deficiency: what we should- or should not-be doing. J. Clin. Pathol. 54 (2001) 337-338
5. Cunningham-Rundles C., and Bodian C. Common variable immunodeficiency: clinical and immunological features of 248 patients. Clin. Immunol. 92 (1999) 34-48
6. Knight A.K., and Cunningham-Rundles C. Inflammatory and autoimmune complications of common variable immune deficiency. Autoimmun. Rev. 5 (2006) 156-159
7. Sundin U., Nava S., and Hammarstrom L. Induction of unresponsiveness against IgA in IgA-deficient patients on subcutaneous immunoglobulin infusion therapy. Clin. Exp. Immunol. 112 (1998) 341-346
8. Warnatz K., Denz A., Drager R., Braun M., Groth C., Wolff-Vorbeck G., Eibel H., Schlesier M., and Peter H.H. Severe deficiency of switched memory B cells (CD27(+)IgM(-)IgD(-)) in subgroups of patients with common variable immunodeficiency: a new approach to classify a heterogeneous disease. Blood 99 (2002) 1544-1551
9. Salzer U., Chapel H.M., Webster A.D., Pan-Hammarstrom Q., Schmitt-Graeff A., Schlesier M., Peter H.H., Rockstroh J.K., Schneider P., Schaffer A.A., Hammarstrom L., and Grimbacher B. Mutations in TNFRSF13B encoding TACI are associated with common variable immunodeficiency in humans. Nat. Genet. 37 (2005) 820-828
10. Castigli E., Wilson S.A., Garibyan L., Rachid R., Bonilla F., Schneider L., and Geha R.S. TACI is mutant in common variable immunodeficiency and IgA deficiency. Nat. Genet. 37 (2005) 829-834
11. Vassallo R.R. Review: IgA anaphylactic transfusion reactions. Part I. Laboratory diagnosis, incidence, and supply of IgA-deficient products. Immunohematology 20 (2004) 226-233
12. Ferreira A., Garcia Rodriguez M.C., Lopez-Trascasa M., Pascual Salcedo D., and Fontan G. Anti-IgA antibodies in selective IgA deficiency and in primary immunodeficient patients treated with gamma-globulin. Clin. Immunol. Immunopathol. 47 (1988) 199-207
13. Cunningham-Rundles C., Zhou Z., Mankarious S., and Courter S. Long-term use of IgA-depleted intravenous immunoglobulin in immunodeficient subjects with anti-IgA antibodies. J. Clin. Immunol. 13 (1993) 272-278
14. Eijkhout H.W., van den Broek P.J., and van der Meer J.W.M. Substitution therapy in immunodeficient patients with anti-IgA antibodies or severe adverse reactions to previous immunoglobulin therapy. Neth. J. Med. 61 (2003) 213-217
15. Vyas G.N., Perkins H.A., and Fudenberg H.H. Anaphylactoid transfusion reactions associated with anti-IgA. Lancet 2 (1968) 312-315
16. Pineda A.A., and Taswell H.F. Transfusion reactions associated with anti-IgA antibodies: report of four cases and review of the literature. Transfusion 15 (1975) 10-15
17. Rivat L., Rivat C., Daveau M., and Ropartz C. Comparative frequencies of anti IgA antibodies among patients with anaphylactic transfusion reactions and among normal blood donors. Clin. Immunol. Immunopathol. 7 (1977) 340-348
18. Herbst E.W., Armbruster M., Rump J.A., Buscher H.P., and Peter H.H. Intestinal B cell defects in common variable immunodeficiency. Clin. Exp. Immunol. 95 (1994) 215-221
19. Cunningham-Rundles C., Wong S., Bjorkander J., and Hanson L.A. Use of an IgA-depleted intravenous immunoglobulin in a patient with an anti-IgA antibody. Clin. Immunol. Immunopathol. 38 (1986) 141-149
20. Chapel H.M., Spickett G.P., Ericson D., Engl W., Eibl M.M., and Bjorkander J. The comparison of the efficacy and safety of intravenous versus subcutaneous immunoglobulin replacement therapy. J. Clin. Immunol. 20 (2000) 94-100
21. Gardulf A., Andersen V., Bjorkander J., Ericson D., Froland S.S., Gustafson R., Hammarstrom L., Jacobsen M.B., Jonsson E., and Moller G. Subcutaneous immunoglobulin replacement in patients with primary antibody deficiencies: safety and costs. Lancet 345 (1995) 365-369