Topomimetics of amphipathic β-sheet and helix-forming bactericidal peptides neutralize lipopolysaccharide endotoxins

Journal of Medicinal Chemistry

Volumn 49, Issue 26, 2006, Pages 7754-7765

  Chen, Xuemei ^a   Dings, Ruud P M ^b   Nesmelova, Irina ^b   Debbert, Stefan ^b   Haseman, Judith R ^a   Maxwell, Jacques ^b   Hoye, Thomas R ^a   Mayo, Kevin H ^b  

^a University of Minnesota   (United States)

^b UNIVERSITY OF MINNESOTA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

5,11,17,23 TETRA TERT BUTYL 25,26,27,28 TETRAKIS(4 GUANIDINOBUTOXY)CALIX[4]ARENE; CALIXARENE; ENDOTOXIN; LIPID A; LIPOPOLYSACCHARIDE; POLYMYXIN B; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BETA SHEET; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG DESIGN; DRUG SYNTHESIS; ELECTRICITY; ENDOTOXEMIA; GRAM NEGATIVE BACTERIUM; HYDROPHOBICITY; KLEBSIELLA PNEUMONIAE; MACROPHAGE; MOLECULAR INTERACTION; MOUSE; NONHUMAN; PROTEIN CONFORMATION; PSEUDOMONAS AERUGINOSA; SALMONELLA TYPHIMURIUM; SEPTIC SHOCK; SERRATIA MARCESCENS;

ANIMALS; ANTI-BACTERIAL AGENTS; ANTIMICROBIAL CATIONIC PEPTIDES; BLOOD BACTERICIDAL ACTIVITY; BLOOD PROTEINS; CALIXARENES; ENDOTOXEMIA; ENDOTOXINS; GRAM-NEGATIVE BACTERIA; HORSESHOE CRABS; LIPID A; LIPOPOLYSACCHARIDES; MAGNETIC RESONANCE SPECTROSCOPY; MALE; MEMBRANE PROTEINS; MICE; MICE, INBRED C57BL; MOLECULAR MIMICRY; NEUTRALIZATION TESTS; POLYMYXIN B; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 33846027521     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm0610447     Document Type: Article

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