Anaphylactoid reaction to recombinant tissue plasminogen activator

European Journal of Emergency Medicine

Volumn 14, Issue 1, 2007, Pages 60-61

  Krmpotic, Kristina R ^a   Fernandes, Christopher M B ^a,b  

^a MCMASTER UNIVERSITY   (Canada)

^b Emergency Medicine   (Canada)

Author keywords

Alteplase; Anaphylactoid reaction; Recombinant tissue plasminogen activator; Stroke

Indexed keywords

ACEBUTOLOL; ADRENALIN; ALTEPLASE; ATORVASTATIN; CELECOXIB; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; DIPHENHYDRAMINE; GLIBENCLAMIDE; HYDROCHLOROTHIAZIDE; LISINOPRIL; METFORMIN; METHYLPREDNISOLONE SODIUM SUCCINATE;

AGED; AIRWAY OBSTRUCTION; ANAPHYLAXIS; ANGIONEUROTIC EDEMA; ARTERY OCCLUSION; ARTICLE; BASILAR ARTERY; BRAIN STEM INFARCTION; CASE REPORT; CEREBROVASCULAR ACCIDENT; COMPUTER ASSISTED TOMOGRAPHY; CONSCIOUSNESS LEVEL; DYSARTHRIA; ENDOTRACHEAL INTUBATION; FEMALE; FIBRINOLYTIC THERAPY; GLASGOW COMA SCALE; HEMIPARESIS; HUMAN; HYPERTENSION; INDUCED HYPOTENSION; MUSCLE RIGIDITY; NON INSULIN DEPENDENT DIABETES MELLITUS; OXYGEN SATURATION; PRIORITY JOURNAL; SIDE EFFECT; SINUS TACHYCARDIA; SLURRED SPEECH; URTICARIA;

AGED; ANAPHYLAXIS; CEREBROVASCULAR ACCIDENT; FEMALE; FIBRINOLYTIC AGENTS; HUMANS; THROMBOLYTIC THERAPY; TISSUE PLASMINOGEN ACTIVATOR;

EID: 33846024765     PISSN: 09699546     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.mej.0000228442.10158.5e     Document Type: Article

References (12)

1. Adams H, Adams R, Del Zoppo G, Goldstein LB. Guidelines for the early management of patients with ischemic stroke (2005 guidelines update). Stroke 2005; 36:916-921.
2. The National Institute of Neurological Disorders and Stroke rt-PA Stroke Study Group. Tissue plasminogen activator for acute ischemic stroke. N Engl J Med 1995; 333:1581-1587.
3. Hill MD, Barber PA, Takahashi J, Demchuck AM, Feasby TE, Buchan AM. Anaphylactoid reactions and angioedema during alteplase treatment of acute ischemic stroke. Can Med Assoc J 2000; 162:1281-1284.
4. Hill MD, Lye T, Moss H, Barber PA, Demchuk AM, Newcommon NJ, et al. Hemi-orolingual angioedema and ACE inhibition after alteplase treatment of stroke. Neurology 2003; 60:1525-1527.
5. Pancioli A, Brott T, Donaldson B, Miller R. Asymmetric angioneurotic edema associated with thrombolysis for acute stroke. Ann Emerg Med 1997; 30:227-229.
6. Rudolf J, Grond M, Schmulling S, Neveling M, Heiss W. Orolingual angioneurotic edema following therapy of acute ischemic stroke with alteplase. Neurology. 2000; 55:599-600.
7. Rudolf J, Grond M, Prince WS, Schmulling S, Heiss WD. Evidence of anaphylaxy after alteplase infusion. Stroke 1999; 30:1142-1143.
8. Reed BR, Chen AB, Tanswell P, Prince WS, Wert RM, Glaesle-Schwarz L, et al. Low incidence of antibodies to recombinant human tissue-plasminogen activator in treated patients. Thromb Haemost 1990; 64:276-280.
9. Pechlaner C, Knapp E, Wiedermann CJ. Hypersensitivity reactions associated with recombinant tissue-type plasminogen activator and urokinase. Blood Coagul Fibrinolysis 2001; 12:491-494.
10. Bennett WR, Yawn DH, Migliore PJ, Young JB, Pratt CM, Raizner AE, et al. Activation of the complement system by recombinant tissue plasminogen activator. J Am Coll Cardiol 1987; 10:627-632.
11. Cyr M, Lepage Y, Blais C, Gervais N, Cugno M, Rouleau JL, et al. Bradykinin and des-Arg(9)-bradykinin metabolic pathways and kinetics of activation of human plasma. Am J Physiol Heart Circ Physiol 2001; 281:275-283.
12. Molinaro G, Gervais N, Adam A. Biochemical basis of angioedema associated with recombinant tissue plasminogen activator treatment: an in vitro experimental approach. Stroke 2002; 33:1712-1716.