Basic insight on plant defensins

Biotecnologia Aplicada

Volumn 23, Issue 2, 2006, Pages 75-78

  Portieles, Roxana ^a   Ayra, Camilo ^a   Borrás, Orlando ^a  

^a CENTER FOR GENETIC ENGINEERING AND BIOTECHNOLOGY   (Cuba)

Author keywords

Cysteine rich peptides; Defensin; Mode of action

Indexed keywords

CYSTEINE; DEFENSIN;

ANTIMICROBIAL ACTIVITY; BIOLOGICAL ACTIVITY; CLINICAL TRIAL; HOST RESISTANCE; HUMAN; INTROSPECTION; PROTEIN FUNCTION; REVIEW; STRUCTURE ACTIVITY RELATION;

FUNGI; HEXAPODA; MAMMALIA;

EID: 33845994724     PISSN: 08644551     EISSN: 10272852     Source Type: Journal    
DOI: None     Document Type: Review

References (41)

1. Ryals JA, Neuenschwander UH, Willits MG, Molina A, Steiner HY, Hunt MD. Systemic acquired resistance. Plant Cell 1996;8:1809-19.
2. Kawata M, Nakajima T, Yamamoto T, Mori K, Oikawa T, Fukumoto F, Kuroda S. Genetic Engineering for Disease Resistance in Rice (Oryzasativa L.) using antimicrobial Peptides. JARQ 2003;37:71-6.
3. Colilla FJ, Rocher R, Mendez E. γ-Purothionins: amino acid sequence of two polypeptides of a new family of thionins from wheat endosperm. FEBS Lett 1990;270:191-4.
4. Terras FRG, Eggermont K, Kovaleva V, Raikhel NV, Osborn RW, Kester A, Ress SB, Torrekens S, Van Leuven F, Vanderleyden J. Small cysteine-rich antifungal proteins from radish: their role in host defense. Plant Cell 1995;7:573-88.
5. Broekaert WF, Terras FRG, Cammue BPA, Osborn RW. Plant defensins: novel antimicrobial peptides as components of the host defense system. Plant Physiol 1995;108:1353-8.
6. Thomma BPHJ, Thevissen K, Cammue BP. Plants defensins. Planta 2002;216:193-202.
7. Almeida MS, Cabral KM, Kurtenbach E, Almeida FC, Valente APJX. Solution structure of Pisum sativum defensin 1 by high resolution NMR: plant defensins, identical backbone with different me-chanisms of action. Mol Biol 2002;315:749-57.
8. Fant F, Vranken WF, Borremans FAM. The three-dimensional solution structure of Aesculus hippocastanum antimicrobial protein 1 determined by 1H nuclear magnetic resonance. Proteins 1999;37:388-403.
9. Bauer F, Schweimer K, Kluver E, Conejo JR, Forssmann WG, Rosch P, Adermann K, Sticht H. Structure determination of human and murine beta-defensins reveals structural conservation in the absence of significant sequence similarity. Protein Sci 2001;10:2470-9.
10. Liu YJ, Cheng CS, Liu YN, Hsu MP, Chen CS, Lyu PC. Solution structure of plant defensin (unpublished).
11. Thomma BP, Cammue BP, Thevissen K. Mode of action of plant defensins suggests therapeutic potential. Curr Drug Targets Infect Disord 2003;3:1-8.
12. Spelbrink RG, Nejmi AA, Thomas JS, Dilip MS, Hockerman GH. Differential Antifungal and Calcium Channel-Blocking Activity among Structurally Related Plant Defensins. Plant Physiology 2004;135:2055-67.
13. Gao AG, Hakimi SM, Mittanck CA, Wu Y, Woerner BM, Stark DM, Shah DM, Shah DM, Liang J, Rommens CM. Fungal pathogen protection in potato by expression of a plant defensin peptide. Nat Biotechnol 2000;18:1307-10.
14. Osborn RW, De Samblanx GW, Thevissen K, Goderis I, Torrekens S, Van Leuven F, Attenborough S, Ress SB, Broekaert WF. Isolation and characterisation of plant defensins from seeds of Asteraceae, Fabaceae, Hippocastanaceae and Saxifragaceae. FEBS Lett 1995;368:257-62.
15. Thevissen K, Osborn RW, Acland DP, Broekaert WF. Specific, high affinity binding sites for an antifungal plant defensin on Neurospora crassa hyphae and microsomal membranes. J Biol Chem 1997;272:32176-81.
16. Thevissen K, Osborn RW, Acland DP, Broekaert WF. Specific binding sites for an antifungal plant defensin from dahlia (Dahlia merckii) on fungal cells are required for antifungal activity. Mol Plant Microbe Interact 2000;13:54-61.
17. Hevissen K, Ghazi A, De Samblanx GW, Brownlee C, Osborn RW, Broekaert WF. Fungal membrane responses induced by plant defensins and thionins. J Biol Chem 1996;271:15018-25.
18. De Samblanx GW, Goderis IJ, Thevissen K, Raemaekers R, Fant F, Borremans F, Acland D P, Osborn R W, Patel S, Broekaert WF. Mutational analysis of a plant defensin from Radish (Raphanus sativus L.) reveals two adjacent sites important for antifungal activity. J Biol Chem 1997;272:1171-9.
19. Bagnat M, Keranen S, Shevchenko A, Simons K. Lipid rafts function in biosynthetic delivery of proteins to the cell surface in yeast. Proc Natl Acad Sci (USA) 2000;97:3254-9.
20. Abrami L, Velluz MC, Hong Y, Ohishi K, Mehlert A, Ferguson M, Kinoshita T, Gisou van der Goot F. The glycan core of GPI-anchored proteins modulates aerolysin binding but is not sufficient: the polypeptide moiety is required for the toxin-receptor interaction. FEBS lett 2002;512:249-54.
21. Xiong YQ, Yeaman MR, Bayer AS. In vitro antibacterial activities of platelet microbicidal protein and neutrophil defensin against Staphylococcus aureusare influenced by antibiotics differing in mechanism of action. Antimicrob Agents Chemother 1999;43:1111-7.
22. Wijaya R, Neumann GM, Condron R, Hughes AB, Polya GM. Defense proteins from seed of Cassia fistula include a lipid transfer protein homologue and a protease inhibitory plant defensin. Plant Sci 2000;159:243-55.
23. Melo FR, Rigden DJ, Franco OL, Mello LV, Ary MB, Crossi de Sa MF, Bloch C. Inhibition of trypsin by cowpea thionin: characterization, molecular modeling, and docking. Proteins Struct Funct Genet 2002;48:311-9.
24. Zhang NY, Jones BL, Tao P. Purifica-tion and characterisation of a new class of insect α-amylase inhibitors from barley. Cereal Chem 1997;74:119-22.
25. Terras FR, Eggermont K, Kovaleva V, Raikhel NV, Osborn RW, Kester A, Ress SB, Torrekens S, Van Leuven F, Vanderleyden J. Small cysteine-rich antifungal proteins from radish: their role in host defense. Plant Cell 1995;7:573-88.
26. Gu Q, Kawata EE, Morse MJ, Wu HM, Cheung AY. A flower-specific cDNA encoding a novel thionin in tobacco. Mol Gen Genet 1992;234:89-96.
27. Moreno M, Segura A, García-Olmedo F. Pseudothionin-St1, a potato peptide active against potato pathogens. Eur J Biochem 1994;223:135-9.
28. Park HC, Kang YH, Chun HJ, Koo JC, Cheong YH, Kim CY, Kim MC, Chung WS, Kim JC, Yoo JH, Koo YD, Koo SC, Lim CO, Lee SY, Cho M J. Characterization of a stamen-specific cDNA encoding a novel plant defensin in Chinese cabbage. Plant Mol Biol 2002;50:59-69.
29. Roder BL, Wandall DA, Frimodt-Moller N, Espersen F, Skinhoj P, Rosdahl VT. Clinical features of Staphylococcus aureus endocarditis: a 10-year experience in Denmark. Archives Internal Medicine 1999;159:462-9.
30. Novak R, Henriques B, Charpentier E, Normark S, Tuomanen E. Emergente of vancomycin tolerante in Streptococcus pneumoniae. Nature 1999;399:590-1.
31. De Lucca AJ. Antifungal peptides: potential candidates for the treatment of fungal infections. Expert Opinion on Investigational Drugs 2000;9:273-99.
32. Hancock REW. Cationic antimicrobial peptides: towards clinical applications. Expert Opinion on Investigational Drugs 2000;9:1723-9.
33. Welling MM, Paulusma-Annema A, Balter HS, Pauwels EK, Nibbering PH. Tenehtium-99m labeled antimicrobial peptide discriminate between bacterial infection and sterile inflammations. European Journal of Nuclear Medicine 2000;27:292-301.
34. Selitrennikoff CP. Antifungal proteins. Applied and Environmental Microbiology 2001;67:2883-94.
35. Tanaka K. P-13- kinase p85 is a target molecule of proline-rich antimicrobial peptide to suppress proliferation of ras- transformed cells. Japanese Journal of Cancer Research 2001;92:959-67.
36. Chinchar VG, Wang J, Murti G, Carey C, Rollins-Smith L. Inactivation of frog virus 3 and channel catfish virus by esculentin-2P and ranatuerin-2P, two antimicrobial peptides isolated from frog skin. Virology 2001;288:352-7.
37. Andersen J, Osbakk S, Vorland L, Traavik T, Gutteberg T. Lactoferrin and cyclic lactoferricin inhibit the entry of human cytomegalovirus into human fibroblasts. Antiviral Research 2001;51:141-9.
38. Chernysh S, Kim SI, Beckeer G, Pleskach VA, Filatova NA, Anikin VB, Platonov VG, Bulet P. Antiviral and antitumor peptides from insects. Proceeding of the National Academy of Science (USA) 2002;99:12628-32.
39. Marshall SH, Arenas G. Antimicrobial peptides: A natural alternative to chemical antibiotics and a potential for applied biotechnology 2003;6:271-84.
40. Gura T. Innate Immunity. Ancient System Gets New Respect. Science 2001;291:2068-71.
41. Zasloff M. Antimicrobial peptides of multi-cellular organisms. Nature 2002;415:389-95.