On parallel and antiparallel topology of a homodimeric multidrug transporter

Journal of Biological Chemistry

Volumn 281, Issue 47, 2006, Pages 36205-36212

  Soskine, Misha ^a   Mark, Shirley ^a   Tayer, Naama ^a   Mizrachi, Roy ^a   Schuldiner, Shimon ^a  

^a HEBREW UNIVERSITY OF JERUSALEM   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIPARALLEL TOPOLOGY; BIOCHEMICAL DATA; MULTIDRUG TRANSPORTER;

CELLS; CROSSLINKING; CRYSTALLIZATION; DIMERS; DRUG PRODUCTS; MONOMERS;

BIOCHEMISTRY;

CYSTEINE; DETERGENT; GLYCOPROTEIN P; HOMODIMER; MALEIMIDE; MEMBRANE PROTEIN; MONOMER; MUTANT PROTEIN; OCTYL GLUCOSIDE; PROTEIN EMRE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; CROSS LINKING; CRYSTALLIZATION; EQUILIBRIUM CONSTANT; GENE PROBE; KINETICS; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN FUNCTION; PROTEIN INTERACTION; PROTEIN PURIFICATION; PROTEIN TRANSPORT; PROTEOLIPOSOME; THERMOSTABILITY;

ANTIPORTERS; CROSS-LINKING REAGENTS; CYSTEINE; DETERGENTS; DIMERIZATION; DRUG RESISTANCE, MULTIPLE; ESCHERICHIA COLI PROTEINS; HEAT; KINETICS; MALEIMIDES; MODELS, MOLECULAR; MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS; MUTAGENESIS, SITE-DIRECTED; PARAQUAT; PROTEIN BINDING; PROTEIN CONFORMATION;

EID: 33845991863     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M607186200     Document Type: Article

References (35)

1. Abramson, J., Smirnova, I., Kasho, V., Verner, G., Kaback, H. R., and Iwata, S. (2003) Science 301, 610-615
2. Huang, Y., Lemieux, M. J., Song, J., Auer, M., and Wang, D. N. (2003) Science 301, 616-620
3. Gouaux, E., and Mackinnon, R. (2005) Science 310, 1461-1465
4. Locher, K. P., Bass, R. B., and Rees, D. C. (2003) Science 301, 603-604
5. Andersen, O. S., Apell, H. J., Bamberg, E., Busath, D. D., Koeppe, R. E., II, Sigworth, F. J., Szabo, G., Urry, D. W., and Woolley, A. (1999) Nat. Struct. Biol. 6, 609
6. Davidson, A. L., and Chen, J. (2005) Science 308, 963-965
7. Pornillos, O., Chen, Y. J., Chen, A. P., and Chang, G. (2005) Science 310, 1950-1953
8. Ma, C., and Chang, G. (2004) Proc. Natl. Acad. Sci. U. S. A. 101, 2852-2857
9. Tate, C. G., Ubarretxena-Belandia, I., and Baldwin, J. M. (2003) J. Mol. Biol. 332, 229-242
10. Ubarretxena-Belandia, I., Baldwin, J. M., Schuldiner, S., and Tate, C. G. (2003) EMBO J. 22, 6175-6181
11. Murata, K., Mitsuoka, K., Hirai, T., Walz, T., Agre, P., Heymann, J. B., Engel, A., and Fujiyoshi, Y. (2000) Nature 407, 599-605
12. Dutzler, R., Campbell, E. B., Cadene, M., Chait, B. T., and MacKinnon, R. (2002) Nature 415, 287-294
13. Yamashita, A., Singh, S. K., Kawate, T., Jin, Y., and Gouaux, E. (2005) Nature 437, 215-223
14. Ninio, S., Elbaz, Y., and Schuldiner, S. (2004) FEBS Lett. 562, 193-196
15. Soskine, M., Steiner-Mordoch, S., and Schuldiner, S. (2002) Proc. Natl. Acad. Sci. U. S. A. 99, 12043-12048
16. Pornillos, O., and Chang, G. (2006) FEBS Lett. 580, 358-362
17. Bowie, J. U. (2006) Nat. Struct. Mol. Biol. 13, 94-96
18. Rapp, M., Granseth, E., Seppala, S., and von Heijne, G. (2006) Nat. Struct. Mol. Biol. 13, 112-116
19. Goldberg, E. B., Arbel, T., Chen, J., Karpel, R., Mackie, G. A., Schuldiner, S., and Padan, E. (1987) Proc. Natl. Acad. Sci. U. S. A. 84, 2615-2619
20. Tabor, S., and Richardson, C. (1985) Proc. Natl. Acad. Sci. U. S. A. 82, 1074-1078
21. Muth, T. R., and Schuldiner, S. (2000) EMBO J. 19, 234-240
22. Steiner Mordoch, S., Granot, D., Lebendiker, M., and Schuldiner, S. (1999) J. Biol. Chem. 274, 19480-19486
23. Gutman, N., Steiner-Mordoch, S., and Schuldiner, S. (2003) J. Biol. Chem. 278, 16082-16087
24. Rotem, D., Sal-man, N., and Schuldiner, S. (2001) J. Biol. Chem. 276, 48243-48249
25. Elbaz, Y., Tayer, N., Steinfels, E., Steiner-Mordoch, S., and Schuldiner, S. (2005) Biochemistry 44, 7369-7377
26. Yerushalmi, H., Mordoch, S. S., and Schuldiner, S. (2001) J. Biol. Chem. 276, 12744-12748
27. Yerushalmi, H., Lebendiker, M., and Schuldiner, S. (1995) J. Biol. Chem. 270, 6856-6863
28. Elbaz, Y., Steiner-Mordoch, S., Danieli, T., and Schuldiner, S. (2004) Proc. Natl. Acad. Sci. U. S. A. 101, 1519-1524
29. Green, N. S., Reisler, E., and Houk, K. N. (2001) Protein Sci. 10, 1293-1304
30. Daley, D. O., Rapp, M., Granseth, E., Melen, K., Drew, D., and von Heijne, G. (2005) Science 308, 1321-1323
31. Luecke, H., Schobert, B., Lanyi, J. K., Spudich, E. N., and Spudich, J. L. (2001) Science 293, 1499-1503
32. Chang, G. (2003) J. Mol. Biol. 330, 419-430
33. Sikora, C. W., and Turner, R. J. (2005) Biophys. J. 88, 475-482
34. Molteni, V., Greenwald, J., Rhodes, D., Hwang, Y., Kwiatkowski, W., Bushman, F. D., Siegel, J. S., and Choe, S. (2001) Acta Crystallogr. Sect. D Biol. Crystallogr. 57, 536-544
35. Lolkema, J. S., Abbing, A., Hellingwerf, K. J., and Konings, W. N. (1983) Eur. J. Biochem. 130, 287-292