Effect of lead exposure on serum immunoglobulins and reactive nitrogen and oxygen intermediate

Human and Experimental Toxicology

Volumn 25, Issue 11, 2006, Pages 661-665

  Mishra, K P ^a,c   Chauhan, U K ^b   Naik, Sita ^a  

^a SANJAY GANDHI POSTGRADUATE INSTITUTE OF MEDICAL SCIENCES   (India)

^b APS University Rewa (MP) 486003   (India)

^c DEFENCE INSTITUTE OF PHYSIOLOGY AND ALLIED SCIENCES   (India)

Author keywords

Lead; Neutrophils; Nitric oxide; Super oxide

Indexed keywords

HEAVY METAL; IMMUNOGLOBULIN; IMMUNOGLOBULIN A; LEAD; LEAD ACETATE; LIPOPOLYSACCHARIDE; REACTIVE NITROGEN SPECIES; REACTIVE OXYGEN METABOLITE;

ADULT; ANIMAL CELL; ARTICLE; AUTOIMMUNE DISEASE; BLOOD SAMPLING; COMPARATIVE STUDY; ENVIRONMENTAL EXPOSURE; HUMAN; HUMAN EXPERIMENT; HUMORAL IMMUNITY; IMMUNOGLOBULIN BLOOD LEVEL; IMMUNOREGULATION; INCIDENCE; INFECTION; INNATE IMMUNITY; LEAD BLOOD LEVEL; LEAD POISONING; MACROPHAGE; MALE; MOUSE; NEUTROPHIL; NONHUMAN; NORMAL HUMAN; PRIORITY JOURNAL; SUPERNATANT;

ADULT; ANIMALS; CELL LINE; CELL SURVIVAL; ENVIRONMENTAL POLLUTANTS; HUMANS; IMMUNOGLOBULIN A; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; LEAD; MALE; MICE; MIDDLE AGED; NEUTROPHILS; NITRIC OXIDE; NITRITES; OCCUPATIONAL EXPOSURE; ORGANOMETALLIC COMPOUNDS; RESPIRATORY BURST; ZYMOSAN;

EID: 33845964853     PISSN: 09603271     EISSN: None     Source Type: Journal    
DOI: 10.1177/0960327106070453     Document Type: Article

References (29)

1. Singh VK, Mishra KP, Rani R, Yadav VS, Awasthi SK, Garg SK. Immunomodulation by lead. Immunol Res 2003; 28: 151-65.
2. Mishra KP, Singh VK, Rani R, Yadav VS, Chandran V, Srivastava SP, Seth PK. Effect of lead exposure on the immune response of some occupationally exposed individuals. Toxicology 2003; 188: 251-59.
3. Rabinowitz MB, Wetherill GW, Kopple JD. Magnitude of lead intake from respiration by normal man. J Lab Clin Med 1977; 90: 238-48.
4. Koller LD. Immunotoxicology of heavy metals. Review. Int J Immunopharmacol 1980: 2: 269.
5. Cohen MD, Yang Z, Zelikoff JT. Immunotoxicity of particulate lead: in vitro exposure alters pulmonary macrophage tumor necrosis factor production and activity. J Toxicol Environ Health 1994; 42: 377-92.
6. McCabe MJ Jr, Lawrence DA. Lead, a major environmental pollutant, is immunomodulatory by differential effects on CD4+ T cell subsets. Toxicol Appl Pharmacol 1991; 111: 13-23.
7. Kishikawa H, Song R, Lawrence DA. Interleukin-12 promotes enhanced resistance to Listeria monocytogenes infection of lead exposed mice. Toxicol Appl Phormacol 1997; 147: 180-89.
8. McCabe MJ Jr, Lawrence DA. The heavy metal lead exhibits B cell stimulatory factor activity by enhancing B cell IgA expression and differentiation. J Immunol 1990; 145: 671-77.
9. Ewers U, Stiller-Winkler R, Idel H. Serum immunoglobulin, complement C3 and salivary IgA levels in lead workers. Environ Res 1982; 29: 352-57.
10. Rosen JF. Effect of low level of lead exposure. Science 1992; 256: 94.
11. Bannon DI, Murashchik C, Zapf CR, Farfel MR, Chisolm JJ Jr. Graphite furnace atomic absorption spectroscopic measurement of blood lead in matrix matched standards. Clin Chem 1994; 40: 1730-34.
12. Brostoff J, Scadding GK, Male D, Roitt IM. Clinical immunology. Gower, 1991.
13. Mosmann T. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J Immunol Methods 1983; 65: 55.
14. Mehrotra S, Mishra KP, Maurya R, Srimal RC, Singh VK. Immunomodulation by ethanolic extract of Boerhaavia diffusa roots. Int Immunopharmacol 2001; 2: 979-88.
15. Segal AW, Levi AJ. Cell damage and dye reduction in the quantitative nitroblue tetrazolium test. Clin Exp Immunol 1975; 19: 309-18.
16. Gaworski CL, Sharma R. The effects of heavy metals on 3H-thymidine uptake in lymphocytes. Toxicol Appl Pharmacol 1978; 46: 305-13.
17. Querioz ML, Almedia M, Gallo MI, Hochr NF. Defective neutrophil function in workers occupationally exposed to lead. Pharmacol Toxicol 1993; 72: 73-77.
18. Mishra KP, Yadav VS, Chauhan UK, Naik S, Singh V, Sharma P. Xenobiotic exposure and autoimmunity. J Immunol Immunopathol 2005; 7: 8-15.
19. Kimber I, Stonard MD, Gidlow DA, Niewola Z. Influence of chronic low-level exposure to lead on plasma immunoglobulin concentration and cellular immune function in man. Int Arch Occup Environ Health 1986; 57: 117-25.
20. Ayatollahi M. Study of the impact of blood lead level on humoral immunity in humans. Toxicol Ind Health 2002; 18: 39-44.
21. Karmaus W, Brooks KR, Nebe T, Witten J, Obi-Osius N, Kruse H. Immune function biomarkers in children exposed to lead and organochlorine compounds: a cross-sectional study. Environ Health 2005; 4: 5.
22. Ercal N, Neal R, Treeratphan P, Lutz PM, Hammond TC, Dennery PA, Spitz DR. A role for oxidative stress in suppressing serum immunoglobulin levels in lead-exposed Fisher 344 rats. Arch Environ Contam Toxicol 2000; 39: 251-56.
23. Sarasua SM, Vogt RF, Henderson LO, Jones PA, Lybarger JA. Serum immunoglobulins and lymphocyte subset distributions in children and adults living in communities assessed for lead and cadmium exposure. J Toxicol Environ Health 2000; 60: 1-15.
24. Tian L, Lawrence DA. Lead inhibits nitric oxide production in vitro by murine splenic macrophages. Toxic Appl Pharmacol 1995; 132: 156-63.
25. Tian L, Lawrence DA. Metal induced modulation of nitric oxide production in vitro by murine macrophages: lead, nickel and cobalt utilize different mechanism. Proc Natl Acad Sci USA 1996; 88: 1963-67.
26. Kanematsu M, Tagagi K, Masuda N, Suketa Y. Lead inhibits nitric oxide production transiently by mRNA level in murine macrophage cell lines. Biol Pharm Bull 1996; 19: 949-51.
27. Valentino M, Governa M, Marchiseppe I, Visona I. Effect of lead on polymorpho nuclear leucocyte (PMN) functions in occupationally exposed workers. Arch Toxicol 1991; 65: 685-8.
28. Zelikoff JT, Parsons E, Schlesinger RB. Inhalation of particulate lead oxide disrupts pulmonary macrophage-mediated functions important for host defence and tumour surveillance in the lung. Environ Res 1993; 62: 207-22.
29. Bishayi B, Sengupta M, Ghosh S. Lead induced modulation of splenic macrophage responses on humoral and cell mediated immunity. Acta Microbiol Immunol Hung 2004; 51: 31-45.