Can acute tryptophan depletion modulate brain function in absence of behavioural effects?

Medical Hypotheses

Volumn 68, Issue 3, 2007, Pages 722-

  Fusar Poli, Paolo ^a   Allen, Paul ^a   Cortesi, Mariachiara ^a  

^a UNIVERSITY OF PAVIA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

MONOAMINE; MONOAMINE OXIDASE INHIBITOR; SEROTONIN; SEROTONIN UPTAKE INHIBITOR; TRYPTOPHAN;

BEHAVIOR; BRAIN FUNCTION; DEPRESSION; FUNCTIONAL MAGNETIC RESONANCE IMAGING; GENETIC VARIABILITY; HEREDITY; HUMAN; LETTER; MENTAL DISEASE; MOTIVATION; NEUROTRANSMISSION; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; SEROTONINERGIC SYSTEM; TASK PERFORMANCE;

BEHAVIOR; BRAIN; HUMANS; TRYPTOPHAN;

EID: 33845959271     PISSN: 03069877     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mehy.2006.07.034     Document Type: Letter

References (6)

1. Young S.N., Smith S.E., Pihl R.O., and Ervin F.R. Tryptophan depletion causes a rapid lowering of mood in normal males. Psychopharmacology 87 (1985) 173-177
2. Van der Does A. The effects of tryptophan depletion on mood and psychiatric symptoms. J Affect Disorders 64 (2001) 107-119
3. Lam R., Bowering T., and Tam E. Effects of rapid tryptophan depletion in patients with seasonal affective disorders in natural summer remission. Psychol Med 30 (2000) 79-87
4. Allen P., Cleare A.J., Lee F., Fusar-Poli P., Tunstall N., Fu C.H.Y., et al. Effect of acute tryptophan depletion on pre-frontal engagement. Psychopharmacology 188 2 (2006) 131-143
5. Roiser J.P., Blackwell A.D., Cools R., Clark L., Rubinsztein D.C., Robbins T.W., et al. Serotonin transporter polymorphism mediates vulnerability to loss of incentive motivation following acute tryptophan depletion. Neuropsychopharmacology 31 10 (2006) 2273
6. Neumeister A., Nugent A., and Waldeck T. Neural and behavioural responses to tryptophan depletion in unmedicated patients with remitted MDD and controls. Arch Gen Psychiat 61 (2004) 765-773