Ispronicline: A novel α4β2 nicotinic acetylcholine receptor-selective agonist with cognition-enhancing and neuroprotective properties

Journal of Molecular Neuroscience

Volumn 30, Issue 1-2, 2006, Pages 19-20

  Lippiello, Patrick ^a   Letchworth, Sharon R ^a   Gatto, Gregory J ^a   Traina, Vincent M ^a   Bencherif, Merouane ^a  

^a TARGACEPT INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ISPRONICLINE; N METHYL 5 (3 (5 ISOPROPOXYPYRIDINYL)) 4 PENTEN 2 AMINE; N-METHYL-5-(3-(5-ISOPROPOXYPYRIDINYL))-4-PENTEN-2-AMINE; NEUROPROTECTIVE AGENT; NICOTINIC RECEPTOR; NICOTINIC RECEPTOR ALPHA4BETA2; PYRIDINE DERIVATIVE;

BRAIN ISCHEMIA; BRAIN SLICE; CELL DEATH; CONCENTRATION RESPONSE; CONFERENCE PAPER; DRUG ACTIVITY; DRUG SAFETY; DRUG TOLERABILITY; HIPPOCAMPUS; HUMAN; IN VITRO STUDY; NEUROPROTECTION; NONHUMAN; SYNAPTIC TRANSMISSION; ALZHEIMER DISEASE; ANIMAL; ARTICLE; COGNITION; DRUG EFFECT; MEMORY; ORAL DRUG ADMINISTRATION; PHYSIOLOGY; PSYCHOLOGICAL ASPECT;

ADMINISTRATION, ORAL; ALZHEIMER DISEASE; ANIMALS; COGNITION; HUMANS; MEMORY; NEUROPROTECTIVE AGENTS; PYRIDINES; RECEPTORS, NICOTINIC;

EID: 33845947193     PISSN: 08958696     EISSN: None     Source Type: Journal    
DOI: 10.1385/JMN:30:1:19     Document Type: Conference Paper

References (4)

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3. Bontempi B., Whelan K. T., Risbrough V. B., Rao T. S., Buccafusco J. J., Lloyd G. K., and Menzaghi F. (2001) SIB-1553A, (+/-)-4-[[2-(1-methyl-2- pyrrolidinyl)ethyl]thio]phenol hydrochloride, a subtype-selective ligand for nicotinic acetylcholine receptors with putative cognitive-enhancing properties: effects on working and reference memory performances in aged rodents and nonhuman primates. J. Pharmacol. Exp. Ther. 299,297-306.
4. Lippiello P. M., Bencherif M., Gray J. A., Peters S., Grigoryan G., Hodges H., and Collins A. C. (1996) TC-2403: a nicotinic agonist with CNS selectivity. I. In vivo characterization. J. Pharmacol. Exp. Ther. 279, 1422-1429.