Determination of oxomemazine in human plasma by capillary LC-ESI-MS

Journal of Liquid Chromatography and Related Technologies

Volumn 30, Issue 3, 2007, Pages 393-403

  Saber, A L ^a   Elmosallamy, M A F ^a   Wilson, S R ^b   Lundanes, E ^b   Greibrokk, T ^b  

^a Zagazig University   (Egypt)

^b UNIVERSITY OF OSLO   (Norway)

Author keywords

Capillary liquid chromatography; Column switching; Liquid liquid extraction; Mass spectrometry; Oxomemazine

Indexed keywords

BODY FLUIDS; CONCENTRATION (PROCESS); CORRELATION METHODS; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; PLASMA SPRAYING; REACTION KINETICS;

CAPILLARY LIQUID CHROMATOGRAPHY; COLUMN SWITCHING; LIQUID-LIQUID EXTRACTION; OXOMEMAZINE;

AMINES;

AMMONIUM FORMATE; BUFFER; CHLOROFORM; METHYL ORANGE; METRONIDAZOLE; OXOMEMAZINE;

ACCURACY; ARTICLE; AUTOMATION; BLOOD ANALYSIS; CAPILLARY CHROMATOGRAPHY; COMPARATIVE STUDY; CORRELATION COEFFICIENT; DRUG BLOOD LEVEL; DRUG DETERMINATION; ELECTROSPRAY MASS SPECTROMETRY; FEMALE; HUMAN; HUMAN EXPERIMENT; INSTRUMENTATION; ION PAIR EXTRACTION; LIQUID LIQUID EXTRACTION; NORMAL HUMAN; PROCESS DEVELOPMENT; REVERSED PHASE LIQUID CHROMATOGRAPHY; SENSITIVITY ANALYSIS; SOLID PHASE EXTRACTION; ULTRAVIOLET RADIATION; VALIDATION STUDY;

EID: 33845944959     PISSN: 10826076     EISSN: 1520572X     Source Type: Journal    
DOI: 10.1080/10826070601084860     Document Type: Article

References (11)

1. Hoogewijs, G.; Massart, D.L. Development of a standardized analysis strategy for basic drugs, using ion-pair extraction and high performance liquid chromatography. J. Pharm. Biomed. Anal. 1984, 2, 449-463.
2. Hewala, I.I. Stability-indicating HPLC assay for paracetamol, guaiphenesin, sodium benzoate and oxomemazine in cough syrup. Anal. Lett. 1994, 27 (1), 71-93.
3. Hans, M.; Karl, P. Identification of phenothiazine antihistamines and their metabolites in urine. Arch. Toxicol. 1988, 62 (2-3), 185-191.
4. Robert, M.; Berges, J.L. Gas chromatographic determination of drugs derived from phenothiazine. Travaux de la Societe de Pharmacie de Montpellier 1970, 30 (1), 69-76.
5. Kelber, J.J. Thin layer chromatographic separation of some psychotropic molecules. Bull. Soc. Pharm. de Strasbourg, 1970, 13 (1), 41-45.
6. Ishii, D. Introduction to Microscale High Performance Liquid Chromatography; VCH: NewYork, USA, 1988.
7. Wilson, S.R.; Boix, F.; Holm, A.; Molander, P.; Lundanes, E.; Greibrokk, T. Determination of bradykinin and arg-bradykinin in rat muscle tissue by microdialysis and capillary column-switching liquid chromatography with mass spectrometric detection. J. Sep. Sci. 2005, 28 (14), 1751-1758.
8. Holm, A.; Wilson, S.R.; Molander, P.; Lundanes, E.; Greibrokk, T. Determination of perfluorooctane sulfonate and perfluorooctanoic acid in human plasma by large volume injection capillary column switching liquid chromatography coupled to electrospray ionization mass spectrometry. J. Sep. Sci. 2004, 27 (13), 1071-1079.
9. Holm, A.; Molander, P.; Lundanes, E.; Ovrebo, S.; Greibrokk, T. Fast and sensitive determination of urinary 1-hydroxypyrene by packed capillary column switching liquid chromatography coupled to micro-electrospray time-of-flight mass spectrometry. J. Chromatogr. B 2003, 794 (1), 175-83.
10. Holm, A.; Molander, P.; Lundanes, E.; Greibrokk, T. Determination of rotenone in river water utilizing packed capillary column switching liquid chromatography with UV and time-of-flight mass spectrometric detection. J. Chromatogr. A 2003, 983 (1-2), 43-50.
11. Didamony, A.M. Extractive spectrophotometric methods for the determination of oxomemazine hydrochloride in bulk and pharmaceutical formulations using bromocresol green, bromocresol purple, and bromophenol blue. Arch. Pharm. Chem. Life. Sci. 2005, 338, 190-197.