Murine mammary carcinoma 4T1 induces a leukemoid reaction with splenomegaly: Association with tumor-derived growth factors

Experimental and Molecular Pathology

Volumn 82, Issue 1, 2007, Pages 12-24

  duPre', Sally A ^a   Hunter Jr , Kenneth W ^a  

^a UNIVERSITY OF NEVADA SCHOOL OF MEDICINE   (United States)

Author keywords

4T1; Growth factors; Leukemoid; Mammary carcinoma; Splenomegaly

Indexed keywords

CANCER GROWTH FACTOR; CD11B ANTIGEN; CD19 ANTIGEN; CD4 ANTIGEN; CD45 ANTIGEN; CD8 ANTIGEN; COLONY STIMULATING FACTOR; COLONY STIMULATING FACTOR 1; GAMMA INTERFERON; GRANULOCYTE COLONY STIMULATING FACTOR; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; MESSENGER RNA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; B LYMPHOCYTE; BAGG ALBINO MOUSE; BONE MARROW CELL; BREAST CARCINOMA; CANCER CELL CULTURE; CANCER MODEL; CANCER SURGERY; CANCER TRANSPLANTATION; CD4 CD8 RATIO; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL HYPERPLASIA; CELL MATURATION; CELL STRUCTURE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DISEASE ASSOCIATION; EXCISION; FEMALE; FEMUR; FLOW CYTOMETRY; GENE EXPRESSION; GRANULOCYTE; HISTOPATHOLOGY; LEUKEMOID REACTION; LEUKOCYTE; LEUKOCYTE COUNT; LYMPHOCYTE COUNT; MOUSE; NONHUMAN; PERIPHERAL CIRCULATION; PHENOTYPE; PROTEIN BLOOD LEVEL; SPLEEN; SPLEEN WEIGHT; SPLENOMEGALY; TRANSCRIPTION REGULATION;

ANIMALS; BONE MARROW; COLONY-STIMULATING FACTORS; FEMALE; FLOW CYTOMETRY; GRANULOCYTE COLONY-STIMULATING FACTOR; GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR; GRANULOCYTES; LEUKEMOID REACTION; LYMPHOCYTES; MAMMARY NEOPLASMS, EXPERIMENTAL; MICE; MICE, INBRED BALB C; NEOPLASM TRANSPLANTATION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SPLENOMEGALY;

ANIMALIA; MURINAE;

EID: 33845944941     PISSN: 00144800     EISSN: 10960945     Source Type: Journal    
DOI: 10.1016/j.yexmp.2006.06.007     Document Type: Article

References (67)

1. Balducci L., and Hardy C.L. High proliferation of early hemopoietic progenitors in tumor-bearing mice. Pathobiology 60 (1992) 68-71
2. Barreda D.R., Hanington P.C., and Belosevic M. Regulation of myeloid development and function by colony stimulating factors. Dev. Comp. Immunol. 28 (2004) 509-554
3. Boggs D.R., Malloy E., Boggs S.S., Chervenick P.A., and Lee R.E. Kinetic studies of a tumor-induced leukemoid reaction in mice. J. Lab. Clin. Med. 89 (1977) 80-92
4. Brach M.A., deVos S., Gruss H.J., and Herrmann F. Prolongation of survival of human polymorphonuclear neutrophils by granulocyte-macrophage colony-stimulating factor is caused by inhibition of programmed cell death. Blood 80 (1992) 2920-2924
5. Bronte V., Wang M., Overwijk W.W., Surman D.R., Pericle F., Rosenberg S.A., and Restifo N.P. Apoptotic death of CD8+ T lymphocytes after immunization: induction of a suppressive population of Mac-1+/Gr-1+ cells. J. Immunol. 161 (1998) 5313-5320
6. Carlsson G., Ekelund E., Stigsson L., and Hafstrom L. Vascularization and tumour volume estimations of solitary liver tumours in rats. Ann. Chir. Gynaecol. 72 (1983) 187-191
7. Colombo M.P., Ferrari G., Stoppacciaro A., Parenza M., Rodolfo M., Mavilio F., and Parmiani G. Granulocyte colony-stimulating factor gene transfer suppresses tumorigenicity of a murine adenocarcinoma in vivo. J. Exp. Med. 173 (1991) 889-897
8. Colombo M.P., Lombardi L., Melani C., Parenza M., Baroni C., Ruco L., and Stoppacciaro A. Hypoxic tumor cell death and modulation of endothelial adhesion molecules in the regression of granulocyte colony-stimulating factor-transduced tumors. Am. J. Pathol. 148 (1996) 473-483
9. Curnutte J.T., and Coates T.D. Disorders of phagocyte function and number. In: Hoffman R., Benz Jr. E.J., and Shattil S.J. (Eds). Hematology: Basic Principles and Practice. 3rd ed. (2000), Churchill Livingstone, Philadelphia, PA 2740
10. Dalal P.R., Rosenthal R., and Sarkar T.J. Leukemoid reaction in pulmonary carcinoma. J. Natl. Med. Assoc. 72 (1980) 683-686
11. Dexter D.L., Kowalski H.M., Blazar B.A., Fligiel Z., Vogel R., and Heppner G.H. Heterogeneity of tumor cells from a single mouse mammary tumor. Cancer Res. 38 (1978) 3174-3181
12. Di Carlo E., Forni G., Lollini P., Colombo M.P., Modesti A., and Musiani P. The intriguing role of polymorphonuclear neutrophils in antitumor reactions. Blood 97 (2001) 339-345
13. Dorshkind K. In vivo administration of recombinant granulocyte-macrophage colony-stimulating factor results in a reversible inhibition of primary B lymphopoiesis. J. Immunol. 146 (1991) 4204-4208
14. Ferrer A., Cervantes F., Hernandez-Boluda J.C., Alvarez A., and Montserrat E. Leukemoid reaction preceding the diagnosis of colorectal carcinoma by four years. Haematologica 84 (1999) 671-672
15. Fulop G., Lee M.Y., and Rosse C. A granulocytosis-inducing tumor inhibits the production of B lymphocytes in murine bone marrow. J. Immunol. 135 (1985) 4266-4272
16. Heppner G.H., Dexter D.L., DeNucci T., Miller F.R., and Calabresi P. Heterogeneity in drug sensitivity among tumor cell subpopulations of a single mammary tumor. Cancer Res. 38 (1978) 3758-3763
17. Heppner G.H., Miller F.R., and Shekhar P.M. Nontransgenic models of breast cancer. Breast Cancer Res. 2 (2000) 331-334
18. Hestdal K., Ruscetti F.W., Ihle J.N., Jacobsen S.E., Dubois C.M., Kopp W.C., Longo D.L., and Keller J.R. Characterization and regulation of RB6-8C5 antigen expression on murine bone marrow cells. J. Immunol. 147 (1991) 22-28
19. Hocking W., Goodman J., and Golde D. Granulocytosis associated with tumor cell production of colony-stimulating activity. Blood 61 (1983) 600-603
20. Horiguchi J., Warren M.K., Ralph P., and Kufe D. Expression of the macrophage specific colony-stimulating factor (CSF-1) during human monocytic differentiation. Biochem. Biophys. Res. Commun. 141 (1986) 924-930
21. Hough Jr. A.J., Hubbard W.C., and Oates J.A. VX2 carcinoma, pulmonary metastases, and neutrophilic leukocytosis. Possible animal model of tumor-associated granulocytosis. Am. J. Pathol. 112 (1983) 231-237
22. Isenberg J.S. Hematopoietic stem cells mobilization and immune response in tumor-bearing mice. Ann. Plast. Surg. 52 (2004) 523-530
23. Johnson G.R., Whitehead R., and Nicola N.A. Effects of a murine mammary tumor on in vivo and in vitro hemopoiesis. Int. J. Cell Cloning 3 (1985) 91-105
24. Kasuga I., Makino S., Kiyokawa H., Katoh H., Ebihara Y., and Ohyashiki K. Tumor-related leukocytosis is linked with poor prognosis in patients with lung carcinoma. Cancer 92 (2001) 2399-2405
25. Kitamura H., Kodama F., Odagiri S., Nagahara N., Inoue T., and Kanisawa M. Granulocytosis associated with malignant neoplasms: a clinicopathologic study and demonstration of colony-stimulating activity in tumor extracts. Hum. Pathol. 20 (1989) 878-885
26. Kodama T., Kawamura T., and Kobayashi H. Leukemoid reaction in BALB/c mice bearing primary tumors induced by 3-methylcholanthrene. Cancer Res. 38 (1978) 713-715
27. Kusmartsev S., and Gabrilovich D.I. Immature myeloid cells and cancer-associated immune suppression. Cancer Immunol. Immunother. 51 (2002) 293-298
28. Lan S., Rettura G., Levenson S.M., and Seifter E. Granulopoiesis associated with the C3HBA tumor in mice. J. Natl. Cancer Inst. 67 (1981) 1135-1138
29. Lee M.Y., and Rosse C. Replacement of fatty marrow by active granulocytopoietic bone marrow following transplantation of mammary carcinoma into mice. Anat. Rec. 195 (1979) 31-46
30. Lee M.Y., and Rosse C. Depletion of lymphocyte subpopulations in primary and secondary lymphoid organs of mice by a transplanted granulocytosis-inducing mammary carcinoma. Cancer Res. 42 (1982) 1255-1260
31. Lee M., Durch S., Dale D., and Finch C. Kinetics of tumor-induced murine neutrophilia. Blood 53 (1979) 619-632
32. Lee M.Y., Kaushansky K., Judkins S.A., Lottsfeldt J.L., Waheed A., and Shadduck R.K. Mechanisms of tumor-induced neutrophilia: constitutive production of colony-stimulating factors and their synergistic actions. Blood 74 (1989) 115-122
33. Lee M.Y., Fukunaga R., Lee T.J., Lottsfeldt J.L., and Nagata S. Bone modulation in sustained hematopoietic stimulation in mice. Blood 77 (1991) 2135-2141
34. Lee M.Y., Fevold K.L., Dorshkind K., Fukunaga R., Nagata S., and Rosse C. In vivo and in vitro suppression of primary B lymphocytopoiesis by tumor-derived and recombinant granulocyte colony-stimulating factor. Blood 82 (1993) 2062-2068
35. Lee J.K., Back T.C., Komschlies K.L., Ruscetti F.W., Young H.A., and Wiltrout R.H. Hematopoietic switch from lymphoid to granulocytic development in 3LL tumor-bearing mice. In Vivo 15 (2001) 255-263
36. Lieschke G.J., Grail D., Hodgson G., Metcalf D., Stanley E., Cheers C., Fowler K.J., Basu S., Zhan Y.F., and Dunn A.R. Mice lacking granulocyte colony-stimulating factor have chronic neutropenia, granulocyte and macrophage progenitor cell deficiency, and impaired neutrophil mobilization. Blood 84 (1994) 1737-1746
37. MacManus M.P., Elder G.E., Abram W.P., and Bridges J.M. Effect of recombinant human erythropoietin on anemia caused by a murine mammary carcinoma. Exp. Hematol. 18 (1990) 848-852
38. Matsumoto M., Yazawa Y., and Kanzaki M. An autopsy case of liposarcoma with granulocytic leukemoid reaction. Acta Pathol. Jpn. 26 (1976) 399-408
39. Matsumoto M., Sugita Y., and Seya T. Alternative complement pathway-mediated myeloid cell cytotoxicity: repertoire of membrane factors participating in regulation of C3 deposition and cytolysis. Eur. J. Immunol. 21 (1991) 1787-1792
40. McGary C.T., Miele M.E., and Welch D.R. Highly metastatic 13762NF rat mammary adenocarcinoma cell clones stimulate bone marrow by secretion of granulocyte-macrophage colony-stimulating factor/interleukin-3 activity. Am. J. Pathol. 147 (1995) 1668-1681
41. McKee Jr. L.C. Excess leukocytosis (leukemoid reactions) associated with malignant diseases. South. Med. J. 78 (1985) 1475-1482
42. Melhem M.F., Meisler A.I., Saito R., Finley G.G., Hockman H.R., and Koski R.A. Cytokines in inflammatory malignant fibrous histiocytoma presenting with leukemoid reaction. Blood 82 (1993) 2038-2044
43. Metcalf D., and Nicola N.A. Proliferative effects of purified granulocyte colony-stimulating factor (G-CSF) on normal mouse hemopoietic cells. J. Cell. Physiol. 116 (1983) 198-206
44. Morecki S., Yacovlev L., and Slavin S. Effect of indomethacin on tumorigenicity and immunity induction in a murine model of mammary carcinoma. Int. J. Cancer 75 (1998) 894-899
45. Nasser S.M., Choudry U.H., Nielsen G.P., and Ott M.J. A leukemoid reaction in a patient with a dedifferentiated liposarcoma. Surgery 129 (2001) 765-767
46. Nimieri H.S., Makoni S.N., Madziwa F.H., and Nemiary D.S. Leukemoid reaction response to chemotherapy and radiotherapy in a patient with cervical carcinoma. Ann. Hematol. 82 (2003) 316-317
47. O'Keane J.C., Wolf B.C., and Neiman R.S. The pathogenesis of splenic extramedullary hematopoiesis in metastatic carcinoma. Cancer 63 (1989) 1539-1543
48. Oster W., Lindemann A., Mertelsmann R., and Herrmann F. Regulation of gene expression of M-, G-, GM-, and multi-CSF in normal and malignant hematopoietic cells. Blood Cells 14 (1988) 443-462
49. Pekarek L.A., Starr B.A., Toledano A.Y., and Schreiber H. Inhibition of tumor growth by elimination of granulocytes. J. Exp. Med. 181 (1995) 435-440
50. Piacibello W., Lu L., Williams D., Aglietta M., Rubin B.Y., Cooper S., Wachter M., Gavosto F., and Broxmeyer H.E. Human gamma interferon enhances release from phytohemagglutinin-stimulated T4+ lymphocytes of activities that stimulate colony formation by granulocyte-macrophage, erythroid, and multipotential progenitor cells. Blood 68 (1986) 1339-1347
51. Pulaski B.A., Clements V.K., Pipeling M.R., and Ostrand-Rosenberg S. Immunotherapy with vaccines combining MHC class II/CD80+ tumor cells with interleukin-12 reduces established metastatic disease and stimulates immune effectors and monokine induced by interferon gamma. Cancer Immunol. Immunother. 49 (2000) 34-45
52. Redmond III J., Kantor R.S., Auerbach H.E., Spiritos M.D., and Moore J.T. Extramedullary hematopoiesis during therapy with granulocyte colony-stimulating factor. Arch. Pathol. Lab. Med. 118 (1994) 1014-1015
53. Sato K., Terada K., Sugiyama T., Sugiyama T., Masuda H., Kakinuma H., and Kato T. Granulocyte colony-stimulating factor produced by bladder carcinoma of a patient with leukemoid reaction did not affect proliferation of the tumor cells. J. Urol. 151 (1994) 1687-1690
54. Schlick E., Hartung K., Stevenson H.C., and Chirigos M.A. Secretion of colony-stimulating factors by human monocytes and bone marrow cells after in vitro treatment with biological response modifiers. J. Leukocyte Biol. 37 (1985) 615-627
55. Schniewind B., Christgen M., Hauschild A., Kurdow R., Kalthoff H., and Klomp H.J. Paraneoplastic leukemoid reaction and rapid progression in a patient with malignant melanoma: establishment of KT293, a Novel G-CSF-secreting melanoma cell line. Cancer Biol. Ther. 4 (2005) 223-227
56. Serafini P., De Santo C., Marigo I., Cingarlini S., Dolcetti L., Gallina G., Zanovello P., and Bronte V. Derangement of immune responses by myeloid suppressor cells. Cancer Immunol. Immunother. 53 (2004) 64-72
57. Shikishima H., Ikeda H., Yamada S., Yamazaki H., Kikuchi K., Wakisaka A., Kasai N., Shimotono K., and Yoshiki T. HTLV-I pX transgenic rats: development of cytokine-producing mammary carcinomas and establishment of the pX mammary carcinoma cell lines. Leukemia Suppl. 3 (1997) 70-72
58. Stav K., Leibovici D., Siegel Y.I., and Lindner A. Leukemoid reaction associated with transitional cell carcinoma. Isr. Med. Assoc. J. 4 (2002) 223-224
59. Tabuchi T., Soma T., Yonekawa M., Komai T., Hashimoto T., and Adachi A. Reduction of VX2 transplanted tumor by granulocyte depletion using extracorporeal circulation on rabbit models. Anticancer Res. 12 (1992) 795-798
60. Tabuchi T., Ubukata H., Sato S., Nakata I., Goto Y., Watanabe Y., Hashimoto T., Mizuta T., Adachi M., and Soma T. Granulocytapheresis as a possible cancer treatment. Anticancer Res. 15 (1995) 985-990
61. Tabuchi T., Ubukata H., Saniabadi A.R., and Soma T. Granulocyte apheresis as a possible new approach in cancer therapy: a pilot study involving two cases. Cancer Detect. Prev. 23 (1999) 417-421
62. Thomas E., Smith D.C., Lee M.Y., and Rosse C. Induction of granulocytic hyperplasia, thymic atrophy, and hypercalcemia by a selected subpopulation of a murine mammary adenocarcinoma. Cancer Res. 45 (1985) 5840-5844
63. Vasef M.A., Neiman R.S., Meletiou S.D., and Platz C.E. Marked granulocytic proliferation induced by granulocyte colony-stimulating factor in the spleen simulating a myeloid leukemic infiltrate. Mod. Pathol. 11 (1998) 1138-1141
64. Welch D.R., Schissel D.J., Howrey R.P., and Aeed P.A. Tumor-elicited polymorphonuclear cells, in contrast to "normal" circulating polymorphonuclear cells, stimulate invasive and metastatic potentials of rat mammary adenocarcinoma cells. Proc. Natl. Acad. Sci. U. S. A. 86 (1989) 5859-5863
65. Wu Q.D., Wang J.H., Condron C., Bouchier-Hayes D., and Redmond H.P. Human neutrophils facilitate tumor cell transendothelial migration. Am. J. Physiol.: Cell Physiol. 280 (2001) C814-C822
66. Yonekawa M., Kawamura A., Komai T., Agishi T., and Adachi M. Extracorporeal granulocytapheresis for cancer and rheumatoid arthritis. Transfus. Sci. 17 (1996) 463-472
67. Young A.J., and Hay J.B. Rapid turnover of the recirculating lymphocyte pool in vivo. Int. Immunol. 7 (1995) 1607-1615