Structural studies of racecadotril and its process impurities by NMR and mass spectroscopy

Pharmazie

Volumn 61, Issue 12, 2006, Pages 994-998

  Mallikarjun Reddy, K ^a   Moses Babu, J ^a   Sudhakar, P ^a   Sharma, M S P ^a   Sudershan Reddy, G ^a   Vyas, K ^a  

^a DR REDDY'S LABORATORIES LTD   (India)

Author keywords

[No Author keywords available]

Indexed keywords

ACETIC ACID DERIVATIVE; ACETORPHAN; BENZYL 2 METHYL CARBOXIMIDO ACETATE; BENZYL 2 PHENYL ETHYL CARBOXIMIDO ACETATE; BENZYL 2(1 BENZYL VINYL CARBOXIMIDO)ACETATE; UNCLASSIFIED DRUG;

ARTICLE; DRUG IMPURITY; DRUG STRUCTURE; FRAGMENTATION REACTION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; NUCLEAR MAGNETIC RESONANCE;

CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DRUG CONTAMINATION; MAGNETIC RESONANCE SPECTROSCOPY; MASS SPECTROMETRY; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; SPECTROPHOTOMETRY, ULTRAVIOLET; SPECTROSCOPY, FOURIER TRANSFORM INFRARED; THIORPHAN;

EID: 33845940770     PISSN: 00317144     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (4)

1. Alam NH, Asharaf H, Khan WA, Karim MM, Fuchs GJ (2003) Efficacy and tolerability of racecadotril in the treatment of cholera in adults. Gut 52: 1419-1423.
2. Ravindra Kumar Y, Moses Babu J, Sarma MSP, Seshidhar B, Srinivasa Reddy S, Sudarsan Reddy G, Vyas K (2003) Application of LC-MS/MS for the identification of a polar impurity in mosapride, a gastroprokinetic drug. J Pharm Biochem Anal 32: 361-368.
3. Sattanathan P, Moses Babu J, Vyas K, Reddy RB, Rajan ST, Sudhakar P (2006) Structural studies of impurities of risperidone by hyphenated techniques. J Pharm Biochem Anal 40: 598-604.
4. Schwartz JC (2000) Racecadotril: A new approach to the treatment of diarrhoea. Int J Antimicrob Agents 14: 75-79.