Effect of Piper betle on hepatotoxicity and antioxidant defense in ethanol-treated rats

Journal of Herbs, Spices and Medicinal Plants

Volumn 12, Issue 1-2, 2006, Pages 61-72

  Saravanan, R ^a   Ramesh, B ^a   Pugalendi, K V ^a  

^a ANNAMALAI UNIVERSITY   (India)

Author keywords

Antioxidant; Ethanol; Hepatotoxicity; Oxidative damage; Piper betle

Indexed keywords

ALCOHOL; ALKALINE PHOSPHATASE; ALPHA TOCOPHEROL; ANTIOXIDANT; ASCORBIC ACID; BETEL EXTRACT; GAMMA GLUTAMYLTRANSFERASE; GLUTATHIONE; HYDROPEROXIDE; SILYMARIN; THIOBARBITURIC ACID;

ANTIOXIDANT; ETHANOL; HEPATITIS; MEDICINAL PLANT; PLANT EXTRACT; SPICE;

ALCOHOL INTOXICATION; ANIMAL EXPERIMENT; ARTICLE; BILIRUBIN BLOOD LEVEL; CONTROLLED STUDY; DRUG EFFICACY; DRUG SYNTHESIS; LIPID PEROXIDATION; LIVER TOXICITY; MULTIPLE CYCLE TREATMENT; NONHUMAN; PIPER BETLE; RAT;

PIPER BETLE;

EID: 33845918727     PISSN: 10496475     EISSN: 15403580     Source Type: Journal    
DOI: 10.1300/J044v12n01_06     Document Type: Article

References (41)

1. Ahmed, S., V. Singh, and G.S. Rao. 1994. Antioxidant potential in serum and liver of albino rats exposed to benzene. Ind. J. Exp. Biol. 32:203-206.
2. Ali, S.M., and R.K. Mehta. 1970. Preliminary pharmacological and anthelmintic studies of the essential oil of Piper betle Linn. Indian Journal of Pharmacology. 32:132.
3. Baker, H., O. Frankel, B. De Angelis, and S. Feingold. 1980. Plasma tocopherol in man at various times after ingesting free or acetylated tocopherol. Nut. Res. 21:531-536.
4. Burtis, C.A., and E.R. Ashwood. 1989. Clinical Chemistry, 2nd edition. W.S. Saunders. Philadelphia.
5. Campos, R., A. Garrido, R. Guerra, and A. Valenzuela. 1989. Silybin dihemisuccinate protects against glutathione depletion and lipid peroxidation induced by acetainophan on rat liver. Planta Medica. 55:417-419.
6. Chan, H.C., Y.S. Chang, and T.C. Lee. 1984. The mutagenicity of nitrite-treated aqueous extract of Piper betle L. Proc. Nat. Sci. Coun., ROC, Life Sciences. 8:4-10.
7. Chander, R., N.K. Kapur, and B.N. Dhawan. 1994. Picrolive affects γ-glutamyl cycle in liver and brain of Mastomys Natalensis infected with Plasmodium burghei. Ind. J. Exp. Biol.. 32:324-327.
8. Choksi, S., S.S. Patel, and A.K. Saluja. 2000. Silymarin: A promising herbal hepatoprotective drug. Indian Drugs. 37(12):566-569.
9. Ellman, G.C. 1959. Tissue sulfhydryl groups. Arch. Biochem. Biphys. 82:70-77.
10. Ferber, J.L. 1984. The role of calcium in liver cell death. D. Keppler, H. Popper, L. Bianchi, and W. Reutter, eds. Mechanisms of Hepatocyte Injury and Death. MTP Press, Lancaster. pp. 111-118.
11. Fung, H.P., M.C. Kuo, Y.H. Taun, and M.J. Wu. 2000. The pro/antioxidative activities of betel nut (Areca catechu), Piper betle leaf and Piper betle fruit. IFT Annual Meeting. 51E4.
12. Galambos, J.T. 1975. Alcoholic hepatitis. F. Schaffner, C.M. Sleevy, eds. Liv. Dis. International Book Corporation. p. 255.
13. Grant, B.F., M.C. Dufour, and T.C. Harford. 1988. Epidemiology of alcoholic liver disease. Sem. Liv. Dis. 8(1):12-25.
14. Harper, H.A. 1961. The functions and tests of the liver. In: Review of Physiological Chemistry. Lange Medical Publishers, Los Altos, California. pp. 271-283.
15. Ingelman, S.M., I. Johansson, and H. Yin. 1993. Ethanol inducible cytochrome P450 2E1: Genetic polymorphism, regulation and possible role in the etiology of alcohol induced liver diseases. Alcohol. 10:447-452.
16. Ishak, K.G., Hyman, and H.J. Zimmerman. 1991. Alcoholic liver disease-pathologic, pathogenetic and clinical aspects. Alcoholism, Clinical and Experimental Research, 15:45-66.
17. Jacqueline, F.S., G.S. Juliana, G.W. Sheryl, E.K. Usevolod, H.J. Elizabeth, A.W. Steven, J.B. William, Dane Wright, and R.S. Peter. 2000. Acetaminophen hepatotoxicity precipitated by short-term treatment of rats with ethanol and isopentanol. Biochem. Pharmacol. 59:445-454.
18. Jayachandran, M.S. Lalithapriya, and C. Panneerselvam. 1995. Effect of ascorbic acid supplementation on tissue ascorbic acid and nucleic acid content of young and aged rats. J. Clin. Biochem. Nutr. 19:131-136.
19. Jiang, Z.Y., J.U. Hunt, and S.D. Wolff. 1992. Detection of lipid hydroperoxides using the 'fox' method. Analyt. Biochem. 202:384-389.
20. Julia Rashba-Step, Nicholar J. Turro, and Arthur I. Cederbaum. 1993. Increased NADPH and NADH-dependent production of superoxide and hydroxyl radical by microsomes after chronic ethanol treatment. Arch. Biochem. Biphys. 300:401-408.
21. King, E.J., and A.R. Armstrong. 1988. Calcium, phosphorous and phosphatase. Varley, H., ed. Practical Clinical Biochemistry, IVth edition, CBS publication, New Delhi. p. 458.
22. Lieber, C.S., R. Teschke, Y. Hasumura, and L.M. Decarli. 1975. Differences in hepatic and metabolic changes after acute and chronic alcohol consumption. Fed. Proc. 34:2060-2074.
23. Loguercio, C., R. Girolama, and Cuoma. 1998. Determination of plasma α-glutathione-s-transferase in chronic alcohol, relationship with alcohol intake and liver involvement. Alcohol Alcohol. 33:366-372.
24. Luper, S. 1999. A review of plants used in the treatment of liver disease, Part two. Alt. Med. Rev. 4(3):178-189.
25. Malloy, A.F., and K.A. Evelyn. 1937. The determination of bilirubin with the photometric colorimeter. J. Biol. Chem. 119:481-490.
26. Mitra, S.K., S.J. Seshadri, M.V. Venkatakanganna, S. Gopumadhavan, U.V. Udupa, and D.N.K. Sharma. 2000. Effect of HD-03, a herbal formulation in galactosamine induced hepatotoxicity in rats. Ind. J. Phys. Pharmacol. 41(1):82-86.
27. Murakami, A., A.M. Ali, K. Mat-Sallesh, K. Koshimizu, and H. Origashi. 2000. Screening for the in vitro anti-tumor promoting activities of edible plants from Malaysia. Biosc., Biotechnol. Biochem. 64:9-16.
28. Nemesanszyky, E. 1996. Enzyme test in hepatobiliary disease. Donal W. Mass and Sidney B. Rosarki, eds. Enzyme Test in Chemistry. Oxford University Press, New York. pp. 45-56.
29. Nichans, W.G., and B. Samuelson. 1968. Formation of malondialdehyde from phospholipid arachidonate during microsomal lipid peroxidation.Eu. J. Biochem. 6:126-130.
30. Nicotera, P., and S. Orrenis. 1986. Role of thiols in protection against biological reactive intermediates. Adv. Exp. Med. Biol. 197:41-49.
31. Norton, S.A. 1998. Betel: Consumption and consequences. J. Am. Acad. Dermatol. 38(1):81-88.
32. Packer, L., H.J. Trishchler, and K. Wassel. 1997. Neuroprotection by the metabolic antioxidant α-lipoic acid. Free Radical Biology and Medicine. 22:359-378.
33. Rao, A.R., A. Sinha, and R.S. Selvan. 1985. Inhibitory action of Piper betle on the initiation of 7,12-dimethylbenz(a) anthracene induced mammary carcinogenesis in rats. Cancer Letters. 26:207-214.
34. Rathore, J.S., and S.K. Mishra. 1970. Indications of antimitotic activity of Piper betle. East Pharm. 13(15):49.
35. Roe, J.H., and C.A. Kuether. 1946. Detection of ascorbic acid in whole blood and urine through 2,4, DNPH derivative of dehydro ascorbic acid. J. Biol. Chem. 11:145-164.
36. Rollason, J.G., G. Pincherle, and D. Robinson. 1972. Serum gamma-glutamyl transpeptidase in relation to alcohol consumption. Clinica Chimica Acta. 39:75-80.
37. Rosalki, S.B., and D. Rau. 1972. Serum gamma-glytamyl transpeptidase activity in alcoholism. Clinica Chimica Acta. 39:41-47.
38. Sethi and Agarwal. 1989. The Wealth of India, Raw Material, Vol. VII: Ph-Re. Publications and Information Directorate, CSIR, New Delhi. pp. 83-94.
39. Shitut, S., V. Pandit, and B.K. Mehta. 1999. The antimicrobial efficiency of Piper betle Linn. leaf (stalk) against human pathogenic bacteria and phytopathogenic fungi. Cent. Europ. J. Pub. Heal. 7:137-139.
40. Varier, P.S. 1997. Indian Medicinal Plants, Orient Longmann Press, Kottakkal, India. pp. 279-283.
41. Wang, M., L. La Grange, F. Reyes, and J. Tao. 1996. Hepatoprotective properties of milk thistle extract as measured by ethanol-induced enzyme activity in rat model. Fitoterapia. 67: 171.