Transmembrane domains 4, 5, 7, 8, and 10 of the human reduced folate carrier are important structural or functional components of the transmembrane channel for folate substrates

Journal of Biological Chemistry

Volumn 281, Issue 44, 2006, Pages 33588-33596

  Hou, Zhanjun ^a   Ye, Jun ^a   Haska, Christina L ^a   Matherly, Larry H ^a,b  

^a WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b KARMANOS CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FOLATE CARRIER; MUTANTS; SUBSTRATE BINDING; TRANSMEMBRANE CHANNEL;

AMINO ACIDS; CELLS; HYDROPHILICITY; MUTAGENESIS; PROTEINS; SUBSTRATES;

CELL MEMBRANES;

CYSTEINE; FOLIC ACID; FOLINIC ACID; METHOTREXATE; REDUCED FOLATE CARRIER; SODIUM (2 SULFONATOETHYL)METHANETHIOSULFONATE; SULFONIC ACID DERIVATIVE; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; ARTICLE; CONTROLLED STUDY; DRUG INHIBITION; HELA CELL; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN TERTIARY STRUCTURE; WESTERN BLOTTING;

AMINO ACID SEQUENCE; BINDING SITES; CELL LINE; CELL MEMBRANE; CRYSTALLOGRAPHY, X-RAY; CYSTEINE; FOLIC ACID; GENE EXPRESSION; HUMANS; MEMBRANE TRANSPORT PROTEINS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTATION; PROTEIN STRUCTURE, TERTIARY; SUBSTRATE SPECIFICITY;

EID: 33845917533     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M607049200     Document Type: Article

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